Increased Bone Mineral Density in Cervical or Thoracic Diffuse Idiopathic Skeletal Hyperostosis (DISH): A Case-Control Study

Sohn, Seil; Chung, Chun Kee; Han, Inbo; Park, Sung Bae; Kim, Hye-Jin

doi:10.1016/j.jocd.2016.09.001

Cited by 20 publications

(17 citation statements)

References 18 publications

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“…Consistent with our result that patients with OPLL accompanying DISH have significantly higher lumbar spine and femoral neck BMD than control subjects did was reported previously [ 9 ]. Furthermore, in our study showed that the OD group had greater BMD than the O group did, which would suggest that the OD group is more osteogenic than O group.…”

Section: Discussionsupporting

confidence: 94%

“…Other studies that investigated multiple types of ossification of the ligaments, including OPLL, ossification of ligamentum flavum, ossification of anterior longitudinal ligament, DISH, and ossification of nuchal ligament, reported that there were more patients with multiple combined types of ossification than there were those with only one type [ 1 ]. Additionally, both patients with one type and those with multiple types of ossification had significantly greater bone mineral density (BMD) than did those with no ossification [ 7 – 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Factors associated with bone metabolism in patients with cervical ossification of the posterior longitudinal ligament accompanied with diffuse idiopathic skeletal hyperostosis

Horie

Sawaji

Endo

et al. 2018

SICOT-J

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Introduction: Diffuse idiopathic skeletal hyperostosis (DISH) and ossification of the posterior longitudinal ligament (OPLL) are both characterized as ossification in paravertebral ligaments and sometimes present simultaneously, however, the bone metabolism in patients with cervical OPLL accompanying/not accompanying DISH has not well been studied. Thus, a retrospective analysis was performed to understand any differences in bone metabolism in these patients.Methods: Male patients who underwent surgery for OPLL were divided into two groups based on the presence or absence of DISH (OD and O group, respectively). Patients with cervical spondylosis comprised the control group (CS group). Bone mineral density (BMD) and bone metabolism factors were compared among the groups.Results: The OD and O groups had significantly higher body mass indexes (BMIs) than did the CS group. Morphologically, the number of continuous type of OPLL was high in the OD group whereas that of segmental type was higher in the O group. The OD and O group had greater BMD than the CS group. Both TRACP-5b and P1NP were tended to be lower in the OD group whereas Ca and P concentrations were similar level among the groups. Intact parathyroid hormone in OD group was significantly higher than CS group.Discussion: Patients with OPLL accompanying DISH had significantly higher BMD whereas they tend to be lower in bone turnover. Significantly higher i-PTH levels was found in the OD group and would be the characteristic blood marker, but further research on the relationship between DISH and PTH was necessary.

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Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Factors associated with bone metabolism in patients with cervical ossification of the posterior longitudinal ligament accompanied with diffuse idiopathic skeletal hyperostosis

Horie

Sawaji

Endo

et al. 2018

SICOT-J

View full text Add to dashboard Cite

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“…Although the precise definition of AS in elderly is unclear, ASD with SJA resembles AS because 21 out of 31 patients in the ASD with SJA group were applied with the modified New York diagnostic criteria. also reported a significantly higher BMD of the femur neck among patients with DISH matched for age, sex, and BMI than the general population 10,15) . In addition, ASD without SJA completely matched DISH according to Resnick's definition.…”

Section: Discussionmentioning

confidence: 79%

“…In studies involving young patients with AS, bone mineral density (BMD) values of the lumbar spine and femur proximal extremity are generally low with high osteocalcin levels; low BMD increases the risk of fracture [3][4][5][6][7][8][9] . On the contrary, BMD in patients with DISH has been reported to be either higher than or similar to that in age-matched healthy population [10][11][12][13] .…”

Section: Introductionmentioning

confidence: 84%

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Femur Bone Mineral Density and Pentosidine Level Distinguish Ankylosing Spinal Disorder Patients with and without Sacroiliac Ankylosis

Furukawa

Okuyama

Kawano

et al. 2020

Spine Surg Relat Res

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Introduction: When spinal fracture occurred in ankylosing spinal disorder (ASD) patients, it is important to evaluate not only the long lever arm but also bone density and bone quality for the determination of treatment strategies. This case-controlled study examined bone mineral density (BMD), bone metabolism markers, and pentosidine levels in patients with ASD.Methods: Subjects with bridging of minimum four contiguous vertebral bodies were classified into ASD group and the rest into non-ASD group. The former was further divided into two subgroups based on the presence/absence of sacroiliac joint ankylosis (SJA). We compared BMD, bone metabolism markers, and pentosidine levels in these groups. Results:The BMD T and Z scores of the femur proximal extremity were lower in the ASD with SJA group than those in the ASD without SJA group. When groups were matched for age, weight, and eGFR, compared with the non-ASD group, the ASD with SJA group had lower BMD of the lumbar spine and femur proximal extremity and the ASD without SJA group had significantly higher BMDs of the lumbar spine and femur proximal extremity. After matching, the ASD without SJA group showed a significantly higher pentosidine level than the non-ASD group. Conclusions:Patients with SJA have low femur proximal extremity BMD, whereas those with ASD without SJA have a higher BMD of the femur proximal extremity with high pentosidine level.

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Preoperative Preparation of Osteoporotic Patients for Instrumented Spine Surgery

Hartmann

Koller

2019

Evidence for Neurosurgery

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Increased Bone Mineral Density in Cervical or Thoracic Diffuse Idiopathic Skeletal Hyperostosis (DISH): A Case-Control Study

Cited by 20 publications

References 18 publications

Factors associated with bone metabolism in patients with cervical ossification of the posterior longitudinal ligament accompanied with diffuse idiopathic skeletal hyperostosis

Factors associated with bone metabolism in patients with cervical ossification of the posterior longitudinal ligament accompanied with diffuse idiopathic skeletal hyperostosis

Femur Bone Mineral Density and Pentosidine Level Distinguish Ankylosing Spinal Disorder Patients with and without Sacroiliac Ankylosis

Preoperative Preparation of Osteoporotic Patients for Instrumented Spine Surgery

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