Increased bone formation around coated implants

Stadlinger, Bernd; Bierbaum, Susanne; Grimmer, Silke; Schulz, Matthias C.; Kuhlisch, Eberhard; Scharnweber, Dieter; Eckelt, Uwe; Mai, Ronald

doi:10.1111/j.1600-051x.2009.01435.x

Cited by 49 publications

(59 citation statements)

References 17 publications

(28 reference statements)

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“…In a further study this was verified for Coll/CS-coated Ti implants compared to controls after 1 month. However, after 2 months no differences could be detected between these groups indicating that Coll/ CS enhances early bone formation [83]. Nevertheless, studies in osteoporotic rats could not show significant differences in peri-implant bone formation of Coll/CScoating in comparison to uncoated Ti pins after 2 and 4 weeks.…”

Section: In Vivo-analysis Of Coll Type I/ Chondroitin Sulfate Coatingscontrasting

confidence: 58%

“…In a sheep experiment under loading conditions in the tibia the extraction torque of external fixation pins was slightly increased when pins were coated with Coll/CS in comparison to uncoated pins [64]. The favorable in vivo results of Coll/CS coatings on Ti pins were also confirmed by further studies examining dental implants [82][83][84]. In a minipig study the Coll/ CS-coating showed significantly increased bone-implant contact compared to uncoated surfaces after 6 weeks of implantation [82].…”

Section: In Vivo-analysis Of Coll Type I/ Chondroitin Sulfate Coatingssupporting

confidence: 52%

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Surface functionalization of biomaterials with tissue-inductive artificial extracellular matrices

et al. 2013

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Bone tissue engineering includes a broad range of strategies and approaches to improve osteoinductive and osteoconductive properties of biomaterials. One approach is applying components of the native extracellular matrix (ECM) to mimic a favorable environment for bone forming cells like osteoblasts and their progenitors. The development of such artificial extracellular matrices (aECMs) is based on collagen, which can be modified by glycoproteins, proteoglycans and glycosaminoglycans. This article reviews the preparation, immobilization and the biochemical characteristics of these coatings for scaffolds and implants. In addition, the influence of aECM coating on cells, bone-implant contact and new bone formation in small and large animals is discussed.

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Section: In Vivo-analysis Of Coll Type I/ Chondroitin Sulfate Coatingscontrasting

confidence: 58%

Section: In Vivo-analysis Of Coll Type I/ Chondroitin Sulfate Coatingssupporting

confidence: 52%

Surface functionalization of biomaterials with tissue-inductive artificial extracellular matrices

et al. 2013

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“…For dental implants, increases in stability have been reported to begin around the fourth week after placement. 21,26,35 Increases in overall stability can be explained by the new bone formation, which has been reported to begin around dental implants approximately 3 weeks after placement in dogs. 36 Although secondary stability might be expected to increase until complete healing around the MSI has taken place, it leveled off after the fifth week in the present study.…”

Section: Longitudinal Changes Of Msi Stabilitymentioning

confidence: 99%

Stability changes of miniscrew implants over time

Ure¹,

Oliver²,

Kim³

et al. 2011

The Angle Orthodontist

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Purpose: To quantify in vivo changes in miniscrew implant (MSI) stability over time using resonance frequency analysis, and to determine if pilot holes and placement sites affect changes in MSI stability. Materials and Methods: Twenty-two self-tapping MSIs (1.6 mm wide and 9 mm long) were placed in the maxillae of 2 adult beagle dogs (20 months old). The Osstell Mentor was used to measure the implant stability quotient (ISQ) weekly for 8 weeks. A split-mouth design was used to evaluate the effects of 1.1-mm wide, 3-mm deep pilot holes. Results: The MSIs that failed showed significantly (P , .05) greater decreases in ISQ values during the first 3 weeks than the MSIs that remained stable. All of the MSIs that failed (41%) had been placed in nonkeratinized tissue. MSIs that remained stable throughout the study also showed significant decreases in ISQ values during the first 3 weeks, followed by increases during the fourth and fifth weeks. Changes in ISQ values of MSIs inserted into bone with and without pilot holes were comparable (P . .05). Conclusion: Stability of unloaded MSIs decreased during the first 3 weeks and increased thereafter. Although the effects of pilot holes on stability could not be confirmed, placement of MSIs into nonkeratinized tissue negatively affected their stability and increased the likelihood of failures. (Angle Orthod. 2011;81:994-1000.)

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“…1 Polysaccharides, including glycosaminoglycans have been used for implant surface coating, based on both the direct and indirect adhesion mechanism. [12][13][14][15][16][17][18][19][20][21] The advantage of polysaccharides compared to proteins as nanocoating material is that they stay longer at the coated surface and therefore have a cell attracting effect for a longer time. 14 22 23 Thus, the properties enable polysaccharides to carry signal molecules and support biologically active substances.…”

Section: Introductionmentioning

confidence: 99%

Nanocoating of Titanium Implant Surfaces with Organic Molecules. Polysaccharides Including Glycosaminoglycans

Gurzawska¹,

Svava²,

Jørgensen³

et al. 2012

Journal of Biomedical Nanotechnology

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Long-term stability of titanium implants are dependent on a variety of factors. Nanocoating with organic molecules is one of the method used to improve osseointegration. Nanoscale modification of titanium implants affects surface properties, such as hydrophilicity, biochemical bonding capacity and roughness. This influences cell behaviour on the surface such as adhesion, proliferation and differentiation of cells as well as the mineralization of the extracellular matrix at the implant surfaces. The aim of the present systematic review was to describe organic molecules used for surface nanocoating with focus on polysaccharides including glycosaminoglycans, and how these molecules change surface properties, cell reactions and affect on osseointegartion. The included in vitro studies demonstrated increased cell adhesion, proliferation and mineralization of a number of the tested polysaccharide nanocoatings. The included in vivo studies, showed improvement of bone interface reactions measured as increased Bone-to-Implant Contact length and Bone Mineral Density adjacent to the polysaccharide coated surfaces. Based on existing literature, surface modification with polysaccharide and glycosaminoglycans appears to be an effective way to stimulate bone regeneration on bone-implant interface.

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Increased bone formation around coated implants

Abstract: Data analysis suggests that collagen/CS has a positive influence on bone formation after 1 month of endosseous healing.

Cited by 49 publications

References 17 publications

Surface functionalization of biomaterials with tissue-inductive artificial extracellular matrices

Surface functionalization of biomaterials with tissue-inductive artificial extracellular matrices

Stability changes of miniscrew implants over time

Nanocoating of Titanium Implant Surfaces with Organic Molecules. Polysaccharides Including Glycosaminoglycans

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