Increased BOLD Signals Elicited by High Gamma Auditory Stimulation of the Left Auditory Cortex in Acute State Schizophrenia

Kuga, Hironori; Onitsuka, Toshiaki; Hirano, Yoji; Nakamura, Itta; Oribe, Naoya; Mizuhara, Hiroaki; Kanai, Ryota; Kanba, Shigenobu; Ueno, Takefumi

doi:10.1016/j.ebiom.2016.09.008

Cited by 9 publications

(7 citation statements)

References 45 publications

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“…According to Figures and Table , our results on spatial source phase showed higher variance in the AL of SZs than HCs. This finding is supported by the results of structural MRI data from Pearlson et al () showing differences between SZs and HCs in left anterior and left posterior superior temporal gyrus (STG), and may be due to higher activation in the left hemisphere in schizophrenia (Agcaoglu et al, ; Kuga et al, ).…”

Section: Discussionmentioning

confidence: 59%

Spatial source phase: A new feature for identifying spatial differences based on complex‐valued resting‐state fMRI data

Qiu

Lin

Kuang

et al. 2019

Human Brain Mapping

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Spatial source phase, the phase information of spatial maps extracted from functional magnetic resonance imaging (fMRI) data by data‐driven methods such as independent component analysis (ICA), has rarely been studied. While the observed phase has been shown to convey unique brain information, the role of spatial source phase in representing the intrinsic activity of the brain is yet not clear. This study explores the spatial source phase for identifying spatial differences between patients with schizophrenia (SZs) and healthy controls (HCs) using complex‐valued resting‐state fMRI data from 82 individuals. ICA is first applied to preprocess fMRI data, and post‐ICA phase de‐ambiguity and denoising are then performed. The ability of spatial source phase to characterize spatial differences is examined by the homogeneity of variance test (voxel‐wise F‐test) with false discovery rate correction. Resampling techniques are performed to ensure that the observations are significant and reliable. We focus on two components of interest widely used in analyzing SZs, including the default mode network (DMN) and auditory cortex. Results show that the spatial source phase exhibits more significant variance changes and higher sensitivity to the spatial differences between SZs and HCs in the anterior areas of DMN and the left auditory cortex, compared to the magnitude of spatial activations. Our findings show that the spatial source phase can potentially serve as a new brain imaging biomarker and provide a novel perspective on differences in SZs compared to HCs, consistent with but extending previous work showing increased variability in patient data.

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Section: Discussionmentioning

confidence: 59%

Spatial source phase: A new feature for identifying spatial differences based on complex‐valued resting‐state fMRI data

Qiu

Lin

Kuang

et al. 2019

Human Brain Mapping

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“…The methods were based on a previous study [16]. In the informed consent process, we explained to all participants that the tasks included the presentation of images, but we did not describe the content of the images.…”

Section: Stimuli and Proceduresmentioning

confidence: 99%

Behavioural cue reactivity to alcohol-related and non-alcohol-related stimuli among individuals with alcohol use disorder: An fMRI study with a visual task

et al. 2020

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Patients with alcohol use disorder (AUD) have difficulty controlling their alcohol cravings and thus exhibit increased use and early relapse. Although patients tend to respond more strongly to alcohol-related images than to non-alcohol-related images, few researchers have examined the factors that modulate cravings. Here, we examined whole-brain blood oxygen level-dependent (BOLD) responses to behavioural cues in individuals with AUD and in healthy controls (HCs). The participants included 24 patients with AUD and 15 HCs. We presented visual cues consisting of four beverage-related images (juice, drinking juice, sake, and drinking sake), and the cue reactivity of AUD participants was contrasted with that of HC participants. Multiple comparisons revealed that the AUD group had lower BOLD responses than the HC group in the left precuneus (p = 0.036) and the left posterior cingulate cortex (PCC) (p = 0.044) to images of drinking juice and higher BOLD responses than the HC group in the left PCC (p = 0.044) to images of drinking sake. Furthermore, compared to the HCs, the AUD patients had decreased BOLD responses associated with cue reactivity to drinking juice in the left precuneus during the periods from 15 to 18 s (p = 0.004, df = 37) and 18 to 21 s (p = 0.002, df = 37). Our findings suggest that HCs and AUD patients differ in their responses not to images of alcoholic beverages but to images related to alcohol-drinking behaviour. Thus, these patients appear to have different patterns of brain activity. This information may aid clinicians in developing treatments for patients with AUD.

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“…Induced 40-Hz γ power in the left hemisphere was correlated with AHs in schizophrenia ( Hirano et al, 2015 ). In another, 80-Hz ASSR-BOLD (blood oxygen–level dependent) signal was positively associated with AHs in acute episode schizophrenia ( Kuga et al, 2016 ). Interestingly, when 40-Hz ASSR was divided as early-latency and late-latency γ response, researchers did not find group differences of early or late γ activity signatures between SZ-AH and SZ-non-AH ( Griskova-Bulanova et al, 2016 ).…”

Section: Neurophysiological Researchmentioning

confidence: 98%

The Etiology of Auditory Hallucinations in Schizophrenia: From Multidimensional Levels

Shao

Liao

et al. 2021

Front. Neurosci.

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Enormous efforts have been made to unveil the etiology of auditory hallucinations (AHs), and multiple genetic and neural factors have already been shown to have their own roles. Previous studies have shown that AHs in schizophrenia vary from those in other disorders, suggesting that they have unique features and possibly distinguishable mechanisms worthy of further investigation. In this review, we intend to offer a comprehensive summary of current findings related to AHs in schizophrenia from aspects of genetics and transcriptome, neurophysiology (neurometabolic and electroencephalogram studies), and neuroimaging (structural and functional magnetic resonance imaging studies and transcriptome–neuroimaging association study). Main findings include gene polymorphisms, glutamate level change, electroencephalographic alterations, and abnormalities of white matter fasciculi, cortical structure, and cerebral activities, especially in multiple regions, including auditory and language networks. More solid and comparable research is needed to replicate and integrate ongoing findings from multidimensional levels.

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Increased BOLD Signals Elicited by High Gamma Auditory Stimulation of the Left Auditory Cortex in Acute State Schizophrenia

Cited by 9 publications

References 45 publications

Spatial source phase: A new feature for identifying spatial differences based on complex‐valued resting‐state fMRI data

Spatial source phase: A new feature for identifying spatial differences based on complex‐valued resting‐state fMRI data

Behavioural cue reactivity to alcohol-related and non-alcohol-related stimuli among individuals with alcohol use disorder: An fMRI study with a visual task

The Etiology of Auditory Hallucinations in Schizophrenia: From Multidimensional Levels

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