Increased body mass index makes an impact on brain white-matter integrity in adults with remitted first-episode mania

Abstract

Our findings suggest that increased BMI affects temporo-parietal-occipital brain white-matter integrity in FEM. This highlights the need to further elucidate the relationship between obesity and other neural substrates (including subcortical changes) in BD which may clarify brain circuits subserving the association between obesity and clinical outcomes in BD.

Obesity, but not metabolic syndrome, negatively affects outcome in bipolar disorder

“…One possibility is that obesity is a marker of severity in bipolar disorder. Although this explanation is not supported by the lack of baseline associations of adiposity measures with illness severity in the present sample, neuroimaging and genetic studies suggest bipolar disorder plus obesity may be an important phenotypic subtype characterized by abnormalities in gray and white matter regions involved in generating and regulating emotion (39)(40)(41) or sharing a common genetic risk for type 2 diabetes (e.g. TCF7L2) (3).…”

Diagnosis and body mass index effects on hippocampal volumes and neurochemistry in bipolar disorder

“…Using magnetic resonance imaging (MRI), we found BMI-related gray and white matter (GM and WM) volume reductions and decreased WM integrity in limbic brain areas in patients, but not non-BD comparison subjects. 37, 38, 39 The volume reductions were particularly pronounced in the temporal lobes, especially the right temporal lobe. Our group also demonstrated BMI-related increases in hippocampal glutamate+glutamine in patients.…”

Obesity and frontal‐striatal brain structures in offspring of individuals with bipolar disorder: Results from the global mood and brain science initiative

“…Moreover, replicated evidence indicates that medical disorders (eg obesity) differentially affect individuals with BD and influence illness trajectory and progression . For example, increased body mass index (BMI) has been previously shown to impact GM volumes, as well as white matter (WM) integrity, in first‐episode BD . Conversely, BMI has also been associated with differences in GM volumes in typical, normally developing samples, especially in frontal and limbic brain regions .…”