Increased body mass index associated with autonomic dysfunction in Parkinson's disease

Mochizuki, Hitoshi; Taniguchi, Akitoshi; Nakazato, Yuki; Ishii, Nobuyuki; Ebihara, Yuka; Sugiyama, Takashi; Shiomi, Kazutaka; Nakazato, Masamitsu

doi:10.1016/j.parkreldis.2016.01.007

Cited by 15 publications

(10 citation statements)

References 12 publications

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“…The number of previous studies dealing with the association between autonomic nervous activity and BMI is small. A recent study found that autonomic dysfunction is associated with BMI increase, and disease severity has no association with BMI in patients with early PD . However, those results were the complete opposite of our results and previous studies .…”

Section: Discussioncontrasting

confidence: 99%

Body weight and dysautonomia in early Parkinson's disease

et al. 2016

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Section: Discussioncontrasting

confidence: 99%

Body weight and dysautonomia in early Parkinson's disease

et al. 2016

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“…Generalized sympathetic denervation is common in PD [25][26][27], even in the early phase of disease. Autonomic dysfunction could be responsible for greater fat deposition since sympathetic denervation leads to chronotropic insufficiency and reduced thermogenesis, thus reducing energy expenditure [28]. Therefore, after an initial increase in body weight, a progressive weight loss occurs [4], more pronounced in the advanced stages of disease [19].…”

Section: Discussionmentioning

confidence: 99%

Untangling the relationship between fat distribution, nutritional status and Parkinson’s disease severity

et al. 2019

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Background Parkinson's disease (PD) is responsible for significant changes in body composition. Aims We aimed to test the association between PD severity and fat distribution patterns, and to investigate the potential modifier effect of nutritional status in this association. Methods We enrolled 195 PD subjects consecutively admitted to a university geriatric day hospital. All participants underwent comprehensive clinical evaluation, including assessment of total and regional body composition (dual-energy X-ray absorptiometry, DXA), body mass index, nutritional status (Mini-Nutritional Assessment, MNA), motor disease severity (UPDRS III), comorbidities, and pharmacotherapy. Results The fully adjusted linear regression model showed a negative association between UPDRS III and total body fat in kg and percentage (respectively, B − 0.79; 95% CI − 1.54 to − 0.05 and B − 0.55; 95% CI − 1.04 to − 0.05), percentage android fat (B − 1.07; 95% CI − 1.75 to − 0.39), trunk-leg fat ratio (B − 0.02; 95% CI − 0.04 to − 0.01), trunk-limb fat ratio (B − 0.01; 95% CI − 0.06 to − 0.01) and android-gynoid fat ratio (B − 0.01; 95% CI − 0.03 to − 0.01). After stratification by MNA score, all the parameters of android-like fat distribution resulted negatively associated (p < 0.001 for all) with UPDRS III, but only among subjects with a MNA < 23.5 (risk of malnutrition or malnutrition). Conclusion We found a negative association between severity of motor impairment and total fat mass in PD, more specific with respect to an android pattern of fat distribution. This association seems to be driven by nutritional status, and is significant only among patients at risk of malnutrition or with overt malnutrition.

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“…5 In brief, following a 20-min rest period, patients received an intravenous injection of 111 MBq 123 I-MIBG (Fuji Film RI Pharma, Tokyo, Japan). Planar images of the chest were obtained at two time points after the injection, one at 15 min (early) and the other at 4 h (delayed).…”

Section: I-metaiodobenzylguanidine Myocardial Imagingmentioning

confidence: 99%

“…3,4 Since body weight is determined by many factors, including genetic, epigenetic, metabolic, and environmental parameters, disease severity and BMI do not always correlate with each other in patients with slowly progressive neurodegenerative disorders such as PD. 4 In our previous study, 5 we performed cardiac 123 I-metaiodobenzylguanidine scintigraphy (MIBG) and assessed the coefficient of variation of the R-R interval (CVRR), and showed that increased BMI was correlated with autonomic dysfunction in PD. Neurodegenerative disorders such as PD and multiple system atrophy (MSA) are associated with α synuclein-related neurodegeneration.…”

Section: Introductionmentioning

confidence: 99%