Increased Body Mass Index and Bronchial Impairment in Allergic Rhinitis

Ciprandi, Giorgio; Ricciardolo, Fabio Luigi Massimo; Signori, Alessio; Schiavetti, Irene; Monardo, Margherita; Ferraro, Maria; Cirillo, Ignazio

doi:10.2500/ajra.2013.27.3979

Cited by 17 publications

(21 citation statements)

References 26 publications

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“…Some studies showed that BMI is associated with the prevalence of allergic rhinitis. Our results are similar to the findings of these studies where people with allergic rhinitis have a higher BMI than those who did not suffer from allergic rhinitis [32] [33]. Overweight could have a role in the development of rhinitis [33].…”

Section: Discussionsupporting

confidence: 91%

Near-Road Exposure to Air Pollution and Allergic Rhinitis: A Cross-Sectional Study among Vendors in Dakar, Senegal

Sylla¹,

Faye²,

Fall³

et al. 2017

ODEM

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Introduction: The work environment is one of the main causes of allergic rhinitis. The majority of vendors in Dakar work in places close to roads that are very frequented by vehicles, exposing them to increased air pollution. The study determined the prevalence of allergic rhinitis and its associated risk factors in these vendors. Methods: This was a cross-sectional survey based on a structured questionnaire, conducted among vendors in the neighborhoods of HLM, Medina and Petersen in Dakar, Senegal. A total of 200 vendors were interviewed. Symptoms of allergic rhinitis were defined as the simultaneous presence of rhinorrhea, nasal congestion and sneezing in the absence of respiratory infection. A logistic regression analysis was performed to determine the relationship between socio-demographic characteristics, occupational factors, and allergic rhinitis. Results: Results of the study show a prevalence of 43% of allergic rhinitis among vendors. Multivariate analysis showed that the independent factors associated with allergic rhinitis in these vendors were age

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Section: Discussionsupporting

confidence: 91%

Near-Road Exposure to Air Pollution and Allergic Rhinitis: A Cross-Sectional Study among Vendors in Dakar, Senegal

Sylla¹,

Faye²,

Fall³

et al. 2017

ODEM

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“…10 Ciprandi et al 9 in their study of 100 patients with moderate to severe persistent AR found that BMI values were significantly lower in control subjects (mean 24.0) with respect to patients with rhinitis (mean 25.5). Another study by Ciprandi et al, 11 which included 155 patients with persistent AR alone and 155 healthy controls, established that BMI values were significantly higher in AR patients than in control subjects (p = 0.038). Differences in age range and the reliability of questionnaire-based diagnoses might be responsible for the reported controversial results on nasal allergies.…”

Section: Discussionmentioning

confidence: 99%

“…studies have reported positive associations between increased BMI and AR. [9][10][11] Nevertheless, the mechanism for the association between respiratory allergic diseases and obesity and the reasons for the apparent difference between men and women remain unclear. 2 Because both respiratory allergic diseases and obesity are characterized by inflammation, a common inflammatory pathway has been proposed as a plausible explanation for the association between respiratory allergy and obesity.…”

Section: Introductionmentioning

confidence: 99%

A Clinical Study of Relationship of Body Mass Index with Allergic Rhinitis

Bist¹,

Bhagat²,

Kala³

2016

An International Journal Clinical Rhinology

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Objectives: Although the association between obesity and bronchial asthma (BA) has been gaining more attention, few studies have been conducted concerning the relationship between body mass index (BMI) and other allergic diseases. The purpose of this study is to determine the relationship between allergic rhinitis (AR) and BMI. Materials and methods:This was a retrospective study. Two hundred and ten patients of AR (138 males and 72 females) and 424 healthy controls were included in the study. The BMI of patients and controls were calculated and correlated. Results:The percentage of AR patients with a low BMI was 9.5%, whereas 57.6% had a normal BMI; 21% were preobese and 9.5% were obese. In the control group, 48.6% subjects had normal BMI range followed by preobese 21.2%, underweight 20.3%, and obese 9.9%. Among the overweight (preobese + obese) category, the maximum number of subjects belonged to cases, i.e., 32.8% with an odds ratio (OR) of 0.95 (95% confidence interval (CI) 0.91-1.07). Thus, AR was not associated with high BMI. Among the underweight, the maximum number of subjects belonged to the control group, i.e., 20.3% with an OR of 2.13 (95% CI 1.24-3.68). Thus, AR had no relationship with lower BMI also. It was also observed that more of the female patients (18, 29.1, and 12.5% were underweight, preobese, and obese respectively) had deranged BMI than male patients (5.3, 20.2, and 7.9% were underweight, preobese, and obese respectively). A relative risk of 1.124 (95% CI 1.01-1.23) and 1.04 (95% CI 0.95-1.13) was present in female patients with low and high BMI respectively, which is statistically significant (p = 0.0008). Conclusion:It was concluded that BMI was not associated with increased prevalence of AR. Among the underweight and overweight, AR was more common in females than in males. Thus, BMI had a significant association with AR among female patients. Overall, BMI had no significant association with AR.

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“…Forward steps with basic science, pathophysiology, 25 clinical trials, clinical guidelines, and evidence-based medicine 1,2,4,5,10,11,13,[14][15][16][17]20,21 and one step back with analysis of real-life outcomes (including analysis of failures) 3,6,7,9,12,13,18,19,23,24 will keep us progressing in the right direction, toward better patient care. Forward steps with basic science, pathophysiology, 25 clinical trials, clinical guidelines, and evidence-based medicine 1,2,4,5,10,11,13,[14][15][16][17]20,21 and one step back with analysis of real-life outcomes (including analysis of failures) 3,6,7,9,12,13,18,19,23,24 will keep us progressing in the right direction, toward better patient care.…”

Section: Progressmentioning

confidence: 99%

Editorial

Corey¹

2013

Am J Rhinol�Allergy

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T he current issue of the American Journal of Rhinology and Allergy highlights two major themes that frequently confront the allergist/rhinologist: chronic rhinosinusitis with nasal polyps (CRSwNPs) and allergic rhinitis (AR). Also addressed in this issue is the rare clinical occurrence of hereditary angioedema (HAE), which deserves attention because of newly developed therapies to prevent potentially life-threatening consequences. In a series of excellent articles, the basic challenges confronting the allergist/rhinologist regarding definition, diagnosis, and treatments of these disorders are rigorously evaluated. ALLERGIC RHINITISThe ideal definition of AR would help clinicians and researchers to distinguish it from nonallergic rhinitis (NAR) and mixed rhinitis (AR ϩ NAR). Bernstein 1 points out this may be difficult because of overlapping symptoms. A careful history followed by skin (or in vitro) testing to assess allergic status is recommended. Although Bernstein suggests that therapeutic response may aid diagnosis, more research is needed to determine if this assumption is correct. Providing insight into therapeutic response is the article by Gawlik et al. 2 , in which the mechanism of action of intranasal azelastine therapy is evaluated in NAR. These authors report that an untreated NAR control group showed greater substance P release in nasal lavage fluids after challenge with hypertonic saline than did an azelastine pretreated group. A different approach to defining AR is taken by Larenas-Linnemann et al. 3 who studied patients diagnosed with AR by Mexican allergists. They categorized patients according to U.S. coding practices as seasonal AR and perennial AR and compared it with the European Allergic Rhinitis and Its Impact on Asthma classifications of intermittent versus persistent and mild versus moderate-severe. They observed that the physicians tended to "overdiagnose" perennial AR and intermittent-persistent compared with the patient's assessment.Comorbidities, risk factors, and physiological triggers of AR are explored by several authors. Haavisto et al., 4 using acoustic rhinometry, measured nasal patency changes induced by physical exercise in AR and asthma and found lower area before and after exercise in the allergic group. All three groups (allergic, asthmatic, and controls) experienced improved (ϳ15%) nasal volume/area after exercise. Increased body mass index in AR patients was found by Ciprandi et al. 5 to be associated with increased markers of inflammation compared with normal weight controls and may increase risk for early bronchial impairment. In Western countries, the incidence of concomitant AR and asthma is common, with some estimates as high as 50%. 1 Hong et al. 6 studied the comorbidity of AR and asthma in two southern Chinese cities via a hospital-based cross-sectional survey. The prevalence of concomitant bronchial asthma was only 5.33%.

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Increased Body Mass Index and Bronchial Impairment in Allergic Rhinitis

Abstract: The present study may suggest that BMI assessment should be routinely considered in AR patients for assessing risk for early bronchial impairment, such as suggesting possible evolution to asthma.

Cited by 17 publications

References 26 publications

Near-Road Exposure to Air Pollution and Allergic Rhinitis: A Cross-Sectional Study among Vendors in Dakar, Senegal

Near-Road Exposure to Air Pollution and Allergic Rhinitis: A Cross-Sectional Study among Vendors in Dakar, Senegal

A Clinical Study of Relationship of Body Mass Index with Allergic Rhinitis

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