Increased body mass and depressive symptomatology are associated with hypercholesterolemia, among elderly individuals; results from the MEDIS study

Tyrovolas, Stefanos; Lionis, Christos; Zeimbekis, Akis; Bountziouka, Vassiliki; Micheli, Mary; Katsarou, Alexia; Papairakleous, Natassa; Metallinos, George; Makri, Kornilia; Polychronopoulos, Evangelos; Panagiotakos, Demosthenes B.

doi:10.1186/1476-511x-8-10

Cited by 49 publications

(26 citation statements)

References 33 publications

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“…An association between dyslipidemia and depression has also been reported (Nakao and Yano, 2004; Takeuchi et al , 2009a; Takeuchi et al, 2009b; Tyrovolas et al , 2009). For example, in one study, 1190 older (aged 65 to 100 years) men and women with cardiovascular disease were enrolled in a study intended to evaluate the relationships between elevated serum cholesterol (hypercholesterolemia) and both lifestyle and depression status (Tyrovolas et al , 2009).…”

Section: 0 Adiposity and Depressionmentioning

confidence: 91%

“…For example, in one study, 1190 older (aged 65 to 100 years) men and women with cardiovascular disease were enrolled in a study intended to evaluate the relationships between elevated serum cholesterol (hypercholesterolemia) and both lifestyle and depression status (Tyrovolas et al , 2009). The signs and symptoms of depression were evaluated using the Geriatric Depression Scale (short form) and hypercholesterolemia was defined as total serum cholesterol > 200 mg/dL or use of lipids lowering medication.…”

Section: 0 Adiposity and Depressionmentioning

confidence: 99%

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Eating ourselves to death (and despair): The contribution of adiposity and inflammation to depression

Shelton

Miller

2010

Progress in Neurobiology

207

148

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Obesity and related metabolic conditions are of epidemic proportions in most of the world, affecting both adults and children. The accumulation of lipids in the body in the form of white adipose tissue in the abdomen is now known to activate innate immune mechanisms. Lipid accumulation causes adipocytes to directly secrete the cytokines interleukin (IL) 6 and tumor necrosis factor α (TNFα), but also monocyte chemoattractant protein 1 (MCP-1), which results in the accumulation of leukocytes in fat tissue. This sets up a chronic inflammatory state which is known to mediate the association between obesity and conditions such as cardiovascular disease, type 2 diabetes, and cancer. There is also a substantial literature linking inflammation with risk for depression. This includes the observations that: 1. People with inflammatory diseases such as multiple sclerosis, cardiovascular disease, and psoriasis have elevated rates of depression; 2. Many people administered inflammatory cytokines such as interferon α develop depression that is indistinguishable from depression in non-medically ill populations; 3. A significant proportion of depressed persons show upregulation of inflammatory factors such as IL-6, C-reactive protein, and TNFα; and 4) Inflammatory cytokines can interact with virtually every pathophysiologic domain relevant to depression, including neurotransmitter metabolism, neuroendocrine function, and synaptic plasticity. While many factors may contribute to the association between inflammatory mediators and depression, we hypothesize that increased adiposity may be one causal pathway. Mediational analysis suggests a bi-directional association between adiposity and depression, with inflammation possibly playing an intermediary role.

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Section: 0 Adiposity and Depressionmentioning

confidence: 91%

Section: 0 Adiposity and Depressionmentioning

confidence: 99%

Eating ourselves to death (and despair): The contribution of adiposity and inflammation to depression

Shelton

Miller

2010

Progress in Neurobiology

207

148

View full text Add to dashboard Cite

show abstract

“…In some studies, low cholesterol concentration is associated with depression [93] and in others low levels of HDL and higher levels of TC and LDL-C influence the risk of depression [94,95]. According to seven year follow up study for the assessment of symptoms of late life depression, lipids affect depression according to sex.…”

Section: Dyslipidemiamentioning

confidence: 99%

Diabetes to cardiovascular disease: Is depression the potential missing link?

et al. 2015

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“…The MEDIS study (29) is a health and nutrition survey that was designed to evaluate bio-clinical, lifestyle, behavioural and dietary characteristics of elderly people living on the Eastern Mediterranean islands. A random, populationbased, multi-stage sampling method (i.e.…”

Section: Participantsmentioning

confidence: 99%

Socio-economic status, place of residence and dietary habits among the elderly: the Mediterranean islands study

Katsarou

Tyrovolas

Ψαλτοπούλου

et al. 2010

Public Health Nutr.

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Objective: To investigate whether the socio-economic status (SES) of elderly eastern Mediterranean islanders is associated with their dietary habits, particularly with adherence to the traditional Mediterranean diet. Design: Cross-sectional. Setting: Adherence to the Mediterranean diet was measured by the MedDietScore (range: 0-55), whereas SES was estimated using education and financial status. Subjects: During 2005-2007, 300 men and women from Cyprus, 100 from Samothraki, 142 from Mitilini, 114 from Kefalonia, 131 from Crete, 150 from Lemnos, 150 from Corfu and 103 from Zakynthos (aged 65-100 years), free of known chronic diseases, participated in the survey. Results: Multiple linear regression analysis revealed that belonging to the highest SES was associated with a higher MedDietScore (P , 0?01), after adjusting for potential sociodemographic, lifestyle, dietary and clinical confounders. A significant positive association was also found between MedDietScore and years of school (P 5 0?004), as well as financial status (P 5 0?001). Conclusions: Older Greek people of higher SES seem to follow a relatively healthier diet. Both education and income seem to play a role in this issue. Thus, public health policy makers should focus on people with low SES in order to improve their quality of diet and, consequently, their health status.

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Increased body mass and depressive symptomatology are associated with hypercholesterolemia, among elderly individuals; results from the MEDIS study

Cited by 49 publications

References 33 publications

Eating ourselves to death (and despair): The contribution of adiposity and inflammation to depression

Eating ourselves to death (and despair): The contribution of adiposity and inflammation to depression

Diabetes to cardiovascular disease: Is depression the potential missing link?

Socio-economic status, place of residence and dietary habits among the elderly: the Mediterranean islands study

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