Increased body fat mass and decreased extracellular fluid volume in adults with growth hormone deficiency

Rosén, Thord; Bosæus, Ingvar; Tölli, Jukka; Lindstedt, Göran; Ba, Bengtsson

doi:10.1111/j.1365-2265.1993.tb00974.x

Cited by 253 publications

(153 citation statements)

References 50 publications

(34 reference statements)

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“…Growth hormone (GH), although not as potent and rapidly acting as adrenaline, may be important during exercise and fasting, increasing adipose lipolysis over a period of 2-3 h (Moller et al 1990). However, chronic GH deficiency is associated with accumulation of TAG in adipose tissue (Rosen et al 1993). More recently, there has been interest in macrophage-derived cytokines, for example, interleukin-6, and tumour necrosis factor a modulating adipose tissue lipolysis, although their physiological significance remains unclear (van Hall et al 2003, Jensen 2003.…”

Section: Long-term Regulation Of Fatty Acid Metabolismmentioning

confidence: 99%

Glucocorticoids and fatty acid metabolism in humans: fuelling fat redistribution in the metabolic syndrome

Macfarlane¹,

Forbes²,

Walker³

2008

Journal of Endocrinology

314

235

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Glucocorticoid hormones constitute an integral component of the response to stress, and many of the manifestations of glucocorticoid excess (Cushing's syndrome) are predictable on the basis of their acute effects to raise blood pressure, induce insulin resistance, increase protein catabolism and elevate plasma glucose. However, it appears to be a paradox that the acute lipolytic effect of glucocorticoids is not manifest in long-term weight loss in humans. The effects of glucocorticoids on glucose metabolism are well characterised, involving impaired peripheral glucose uptake and hepatic insulin resistance, and there is mounting evidence that subtle abnormalities in glucocorticoid concentrations in the plasma and/or in tissue sensitivity to glucocorticoids are important in metabolic syndrome. The effects of glucocorticoids on fatty acid metabolism are less well understood than their influence on glucose metabolism. In this article, we review the literature describing the effects of glucocorticoids on fatty acid metabolism, with particular reference to in vivo human studies. We consider the implications for contrasting acute versus chronic effects of glucocorticoids on fat accumulation, effects in different adipose depots and the potential role of glucocorticoid signalling in the pathogenesis and therapy of metabolic syndrome.

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Section: Long-term Regulation Of Fatty Acid Metabolismmentioning

confidence: 99%

Glucocorticoids and fatty acid metabolism in humans: fuelling fat redistribution in the metabolic syndrome

Macfarlane¹,

Forbes²,

Walker³

2008

Journal of Endocrinology

314

235

View full text Add to dashboard Cite

show abstract

“…In contrast, the high leptin concentrations reported in obese subjects point to an insensitivity to endogenous leptin. Since adults with growth hormone (GH) deficiency (GHD) have an increased body fat mass and a decreased fat free mass (5,6), one can expect high levels of serum leptin. GH therapy in adults with GHD decreases body fat mass (7)(8)(9) and thus might be expected to exert an effect on serum leptin levels.…”

Section: Introductionmentioning

confidence: 99%

Serum leptin levels during recombinant human GH therapy in adults with GH deficiency

Janssen¹,

Frölich

Deurenberg

et al. 1997

Eur J Endocrinol

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Objective: Recent studies suggest an involvement of the obese (ob) gene and its product leptin in the regulation of body fat. Since adults with growth hormone deficiency (GHD) have a high body fat mass which can be normalized with recombinant human (rh) GH therapy, we investigated whether GH influences serum leptin directly or indirectly via its lipolytic effect. Design: Fourteen adults with GHD were treated with subcutaneous injections of rhGH given every evening for 52 weeks. Serum leptin, fat mass and body fat percentage were measured at baseline and after 4 and 52 weeks of treatment. Methods: Serum leptin was measured with a commercially available RIA. Total body water was determined by dilution of deuterium. Fat free mass was estimated by assuming a hydration of 73%. Fat mass was estimated by subtracting fat free mass from weight. Results: At baseline, serum leptin levels were exponentially related to body fat percentage (r=0.88; P<0.0005). rhGH treatment for 4 weeks did not significantly influence serum leptin levels, whereas treatment for 52 weeks significantly decreased serum leptin levels (15.6 Ϯ 2.9 to 10.8 Ϯ 2.1 mg/l; P ¼ 0:020). Fat percentage was significantly decreased after 52 weeks of treatment (37.6 Ϯ 2.1 to 33.8 Ϯ 2.5%; P < 0:0005). The decrease in serum leptin could largely be explained by the decrease in body fat percentage, whereas the relation between leptin and body fat percentage did not change. Conclusions:The influence of GH on serum leptin is indirect, via its effect on body fat percentage. European Journal of Endocrinology 137 650-654

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“…In addition, Japanese subjects tend to have a greater percentage of skeletal muscle with higher capillary density. [23][24][25] Japanese subjects when compared with previous studies of these agents in non-Japanese populations. [17][18][19]26) Haemophilia A is a relatively rare disease.…”

Section: Discussionmentioning

confidence: 96%

Evaluation of the safety, pharmacokinetics, and efficacy of recombinant factor VIII fc fusion protein in Japanese subjects with severe haemophilia A: analysis from the A-LONG study

Hanabusa

Shima

Nogami

et al. 2016

Nihon Kessen Shiketsu Gakkaishi

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Japanese subjects in the individualised prophylaxis, weekly prophylaxis, and episodic arms were 3.56, 4.34, and 25.06, respectively. Most bleeding episodes (89.5%) resolved with 1 rFVIIIFc injection. No inhibitors were reported; safety findings were comparable to non-Japanese subjects. Conclusion: rFVIIIFc was safe and efficacious for control and prevention of bleeding in Japanese subjects, with outcomes comparable to non-Japanese subjects.

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Increased body fat mass and decreased extracellular fluid volume in adults with growth hormone deficiency

Abstract: Adult patients with growth hormone deficiency have an increased body weight compared to normals of the same age, sex and height, due to an increment of the body fat with a simultaneous reduction in the total body water.

Cited by 253 publications

References 50 publications

Glucocorticoids and fatty acid metabolism in humans: fuelling fat redistribution in the metabolic syndrome

Glucocorticoids and fatty acid metabolism in humans: fuelling fat redistribution in the metabolic syndrome

Serum leptin levels during recombinant human GH therapy in adults with GH deficiency

Evaluation of the safety, pharmacokinetics, and efficacy of recombinant factor VIII fc fusion protein in Japanese subjects with severe haemophilia A: analysis from the A-LONG study

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