Increased body aluminum. An independent risk factor in patients undergoing long-term hemodialysis?

Serum aluminum level correlates with arterial stiffness in haemodialysis patients

“…In 1988, Chazan et al. (8) reported that increased body aluminum as determined by aluminum blood level or by bone biopsy increases morbidity and mortality and should therefore be considered as an independent risk factor in long‐term HD patients. Chazan et al.…”

“…Factors reportedly associated with increased arterial stiffness in renal patients include age, mean arterial pressure (MAP), pulse pressure (PP), diabetes mellitus (DM), serum calcium, duration of haemodialysis (HD) and C‐reactive protein (CRP) (4–7). High serum aluminum level is an important mortality risk factor in HD patients (8–10). However, the exact mechanism of this relationship is unclear.…”

Aluminium Determination in the Skin of Patients with and without End-Stage Renal Failure

“…Encephalopathy, bone disease, and anemia are well-known clinical and biologi cal complications of Al intoxication. More recently, a relationship between body Al accumulation and neurocognitive dysfunction [1,2] or morbidity [3] in patients on chronic hemodialysis (HD) has been discussed. The Al accumulation is currently assessed by the determination of Al in plasma and the deferoxamine infusion test (DIT).…”