Increased biomagnetic activity in the ventral pathway in mild cognitive impairment

Maestú, Fernando; Campo, Pablo; Río, David del; Moratti, Stephan; Gil-Gregorio, Pedro; Fernández, Alberto; Capilla, Almudena; Ortiz, Tomás

doi:10.1016/j.clinph.2008.01.105

Cited by 33 publications

(24 citation statements)

References 35 publications

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“…The finding that there are between-group differences in the gamma frequency band differs from that found among older individuals with Mild Cognitive Impairment or Alzheimer’s Disease (Fernandez et al, 2006a; Fernandez et al, 2006b; Maestu et al, 2008; Maestu et al, 2006), where abnormalities occur primarily in the delta band. While we found that delta power was correlated with age, it was not associated with cognitive impairment in this younger age group.…”

Section: 0 Discussionmentioning

confidence: 60%

Potential utility of resting-state magnetoencephalography as a biomarker of CNS abnormality in HIV disease

Becker

Fabrizio

Sudre

et al. 2012

Journal of Neuroscience Methods

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There is a lack of a neuroimaging biomarker for HIV-Associated Neurocognitive Disorder. We report magnetoencephalography (MEG) data from patients with HIV disease and risk-group appropriate controls that were collected to determine the MEG frequency profile during the resting state, and the stability of the profile over 24 weeks. 17 individuals (10 HIV+, 7 HIV−) completed detailed neurobehavioral evaluations and 10 minutes of resting-state MEG acquisition with a 306-channel whole-head system. The entire evaluation and MEG measurement were repeated 24 weeks later. Relative MEG power in the delta (0–4 Hz), theta (4–7 Hz), alpha (8–12 Hz), beta (12–30 Hz) and low gamma (30–50 Hz) bands was computed for 8 predefined sensor groups. The median stability of resting-state relative power over 24 weeks of follow-up was 0.80 with eyes closed, and 0.72 with eyes open. The relative gamma power in the right occipital (t(15) = 1.99, p < .06, r = −.46) and right frontal (t(15t) = 2.15, p < .05, r = −.48) regions was associated with serostatus. The effect of age on delta power was greater in the seropositive subjects (r2 = .51) than in the seronegative subjects (r2 = .11). Individuals with high theta-to-gamma ratios tended to have lower cognitive test performance, regardless of serostatus. The stability of the wide-band MEG frequency profiles over 24 weeks supports the utility of MEG as a biomarker. The links between the MEG profile, serostatus, and cognition suggest further research on its potential in HAND is needed.

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Section: 0 Discussionmentioning

confidence: 60%

Potential utility of resting-state magnetoencephalography as a biomarker of CNS abnormality in HIV disease

Becker

Fabrizio

Sudre

et al. 2012

Journal of Neuroscience Methods

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“…From the last years, there is evidence of hyperactivation (Dickerson et al 2005;Maestú et al 2008) or hypersynchronization (Bajo et al 2010) of different regions of the brain in patients with amnestic MCI in comparison to healthy controls but as well to AD patients. This increase is an indication of compensatory activity due to the loss of efficiency of the memory networks that leads to the idea of a nonclear linear neurophysiological process between healthy aging and The table shows the "p" and "r" (correlation index) values that were significant (p<0.05)…”

Section: Discussionmentioning

confidence: 99%

MEG spectral analysis in subtypes of mild cognitive impairment

López

Cuesta

Garcés

et al. 2014

AGE

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Mild cognitive impairment (MCI) has been described as an intermediate stage between normal aging and dementia. Previous studies characterized the alterations of brain oscillatory activity at this stage, but little is known about the differences between single and multidomain amnestic MCI patients. In order to study the patterns of oscillatory magnetic activity in amnestic MCI subtypes, a total of 105 subjects underwent an eyes-closed resting-state magnetoencephalographic recording: 36 healthy controls, 33 amnestic single domain MCIs (a-sd-MCI), and 36 amnestic multidomain MCIs (a-md-MCI). Relative power values were calculated and AGE (2014) compared among groups. Subsequently, relative power values were correlated with neuropsychological tests scores and hippocampal volumes. Both MCI groups showed an increase in relative power in lower frequency bands (delta and theta frequency ranges) and a decrease in power values in higher frequency bands (alpha and beta frequency ranges), as compared with the control group. More importantly, clear differences emerged from the comparison between the two amnestic MCI subtypes. The a-md-MCI group showed a significant power increase within delta and theta ranges and reduced relative power within alpha and beta ranges. Such pattern correlated with the neuropsychological performance, indicating that the a-md-MCI subtype is associated not only with a "slowing" of the spectrum but also with a poorer cognitive status. These results suggest that a-md-MCI patients are characterized by a brain activity profile that is closer to that observed in Alzheimer disease. Therefore, it might be hypothesized that the likelihood of conversion to dementia would be higher within this subtype.

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“…A reduction in cerebral atrophy by as much as seven fold was also observed in grey matter regions, which are the most relevant regions for Alzheimer’s disease pathology [188]. More recently, the use of a new functional neuroimaging technique, magnetoencephalography (MEG), has emerged which can map brain activity and assess cognitive processes and specific functions of the brain [208]. MEG is currently being used in some clinical studies, including cognitive studies in ageing, but to date none have examined B-vitamins.…”

Section: Emerging Roles Of B-vitamin Status In Preventing Diseasesmentioning

confidence: 99%

Causes, Consequences and Public Health Implications of Low B-Vitamin Status in Ageing

et al. 2016

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The potential protective roles of folate and the metabolically related B-vitamins (vitamins B12, B6 and riboflavin) in diseases of ageing are of increasing research interest. The most common cause of folate and riboflavin deficiencies in older people is low dietary intake, whereas low B12 status is primarily associated with food-bound malabsorption, while sub-optimal vitamin B6 status is attributed to increased requirements in ageing. Observational evidence links low status of folate and the related B-vitamins (and/or elevated concentrations of homocysteine) with a higher risk of degenerative diseases including cardiovascular disease (CVD), cognitive dysfunction and osteoporosis. Deficient or low status of these B-vitamins alone or in combination with genetic polymorphisms, including the common MTHFR 677 C → T polymorphism, could contribute to greater disease risk in ageing by causing perturbations in one carbon metabolism. Moreover, interventions with the relevant B-vitamins to optimise status may have beneficial effects in preventing degenerative diseases. The precise mechanisms are unknown but many have been proposed involving the role of folate and the related B-vitamins as co-factors for one-carbon transfer reactions, which are fundamental for DNA and RNA biosynthesis and the maintenance of methylation reactions. This review will examine the evidence linking folate and related B-vitamins with health and disease in ageing, associated mechanisms and public health implications.

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Increased biomagnetic activity in the ventral pathway in mild cognitive impairment

Cited by 33 publications

References 35 publications

Potential utility of resting-state magnetoencephalography as a biomarker of CNS abnormality in HIV disease

Potential utility of resting-state magnetoencephalography as a biomarker of CNS abnormality in HIV disease

MEG spectral analysis in subtypes of mild cognitive impairment

Causes, Consequences and Public Health Implications of Low B-Vitamin Status in Ageing

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