Increased barium influx and potassium current in stroke-prone spontaneously hypertensive rats.

Liu, Yu; Jones, Allan W.; Sturek, Michael

doi:10.1161/01.hyp.23.6.1091

Cited by 30 publications

(15 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Subsequent studies using the patch clamp technique provided additional evidence regarding increased BK channel function in VSMCs during hypertension. In agreement with vessel reactivity studies, results published from several laboratories indicate that compared to control, whole cell K + current through iberiotoxin-sensitive BK channels is elevated in VSMCs from aorta of SHR, stroke-prone SHR, and rats with renal hypertension [150,151,153,154,161]. Additionally, myocytes from mesenteric arteries of DOCA salt-induced hypertensive rats also exhibited elevated iberiotoxin-sensitive K + current compared to myocytes from Sham animals [165].…”

Section: Vascular Ion Channel Remodeling During Hypertensionsupporting

confidence: 70%

Ion channel remodeling in vascular smooth muscle during hypertension: Implications for novel therapeutic approaches

Joseph¹,

Thakali

Moore

et al. 2013

Pharmacological Research

View full text Add to dashboard Cite

Ion channels are multimeric, transmembrane proteins that selectively mediate ion flux across the plasma membrane in a variety of cells including vascular smooth muscle cells (VSMCs). The dynamic interplay of Ca2+ and K+ channels on the plasma membrane of VSMCs plays a pivotal role in modulating the vascular tone of small arteries and arterioles. The abnormally-elevated arterial tone observed in hypertension thus points to an aberrant expression and function of Ca2+ and K+ channels in the VSMCs. In this short review, we focus on the three well-studied ion channels in VSMCs, namely the L-type Ca2+ (CaV1.2) channels, the voltage-gated K+ (KV) channels, and the large-conductance Ca2+-activated K+ (BK) channels. First, we provide a brief overview on the physiological role of vascular CaV1.2, KV and BK channels in regulating arterial tone. Second, we discuss the current understanding of the expression changes and regulation of CaV1.2, KV and BK channels in the vasculature during hypertension. Third, based on available proof-of-concept studies, we describe the potential therapeutic approaches targeting these vascular ion channels in order to restore blood pressure to normotensive levels.

show abstract

Section: Vascular Ion Channel Remodeling During Hypertensionsupporting

confidence: 70%

Ion channel remodeling in vascular smooth muscle during hypertension: Implications for novel therapeutic approaches

Joseph¹,

Thakali

Moore

et al. 2013

Pharmacological Research

View full text Add to dashboard Cite

show abstract

“…Electrophysiological studies have reported increased (282, 286), decreased (170, 171, 279, 288, 886, 947, 1414), or no change (887, 890) in K V current density. One possible explanation for these differences relates to the experimental conditions used to study K V currents; examination of studies on SMCs from the same vessel, recorded in the same lab are particularly illuminating (282, 288).…”

Section: Kv Channelsmentioning

confidence: 99%

Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles

Tykocki

Boerman

Jackson

2017

Comprehensive Physiology

270

347

View full text Add to dashboard Cite

Vascular tone of resistance arteries and arterioles determines peripheral vascular resistance, contributing to the regulation of blood pressure and blood flow to, and within the body’s tissues and organs. Ion channels in the plasma membrane and endoplasmic reticulum of vascular smooth muscle cells (SMCs) in these blood vessels importantly contribute to the regulation of intracellular Ca2+ concentration, the primary determinant of SMC contractile activity and vascular tone. Ion channels provide the main source of activator Ca2+ that determines vascular tone, and strongly contribute to setting and regulating membrane potential, which, in turn, regulates the open-state-probability of voltage gated Ca2+ channels (VGCCs), the primary source of Ca2+ in resistance artery and arteriolar SMCs. Ion channel function is also modulated by vasoconstrictors and vasodilators, contributing to all aspects of the regulation of vascular tone. This review will focus on the physiology of VGCCs, voltage-gated K+ (KV) channels, large-conductance Ca2+-activated K+ (BKCa) channels, strong-inward-rectifier K+ (KIR) channels, ATP-sensitive K+ (KATP) channels, ryanodine receptors (RyRs), inositol 1,4,5-trisphosphate receptors (IP3Rs), and a variety of transient receptor potential (TRP) channels that contribute to pressure-induced myogenic tone in resistance arteries and arterioles, the modulation of the function of these ion channels by vasoconstrictors and vasodilators, their role in the functional regulation of tissue blood flow and their dysfunction in diseases such as hypertension, obesity, and diabetes.

show abstract

“…6 The majority of studies show that the functional expression of BK Ca channels in VSMCs increases during hypertension. [7][8][9][10][11][12][13][14][15] This important local protective mechanism keeps cerebral blood flow at normal or near-normal levels during chronic hypertension. 16,17 In cerebral artery smooth muscle cells (CASMCs), spontaneous and local increases of intracellular Ca 2+ because of the opening of ryanodine receptors (RyRs) in the sarcoplasmic reticulum (SR), visualized as Ca 2+ sparks, activate BK Ca channels on the sarcolemma and so generate spontaneous transient outward currents (STOCs).…”

mentioning

confidence: 99%

Exercise Prevents Upregulation of RyRs–BK _Ca Coupling in Cerebral Arterial Smooth Muscle Cells From Spontaneously Hypertensive Rats

Shi

Zhang

Liu

et al. 2016

ATVB

View full text Add to dashboard Cite

show abstract

Increased barium influx and potassium current in stroke-prone spontaneously hypertensive rats.

Cited by 30 publications

References 27 publications

Ion channel remodeling in vascular smooth muscle during hypertension: Implications for novel therapeutic approaches

Ion channel remodeling in vascular smooth muscle during hypertension: Implications for novel therapeutic approaches

Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles

Exercise Prevents Upregulation of RyRs–BK _Ca Coupling in Cerebral Arterial Smooth Muscle Cells From Spontaneously Hypertensive Rats

Contact Info

Product

Resources

About

Increased barium influx and potassium current in stroke-prone spontaneously hypertensive rats.

Cited by 30 publications

References 27 publications

Ion channel remodeling in vascular smooth muscle during hypertension: Implications for novel therapeutic approaches

Ion channel remodeling in vascular smooth muscle during hypertension: Implications for novel therapeutic approaches

Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles

Exercise Prevents Upregulation of RyRs–BK Ca Coupling in Cerebral Arterial Smooth Muscle Cells From Spontaneously Hypertensive Rats

Contact Info

Product

Resources

About

Exercise Prevents Upregulation of RyRs–BK _Ca Coupling in Cerebral Arterial Smooth Muscle Cells From Spontaneously Hypertensive Rats