Increased B-type natriuretic peptide levels in early-onset versus late-onset preeclampsia

Szabó, Gábor; Molvarec, Attila; Nagy, Béla; Rigó, János

doi:10.1515/cclm-2013-0307

Cited by 21 publications

(18 citation statements)

References 37 publications

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“…Seven studies reported on BNP levels,78, 79, 80, 81, 82, 83, 84 of which three were applicable for a meta‐analysis ( Figure 5). 78, 79, 80 …”

Section: Resultsmentioning

confidence: 99%

“…One study reported on FABP4 levels in pre-eclampsia compared with controls and found statistically higher FABP4 levels in pre-eclampsia vs. non-hypertensive pregnancy. 77 Myocardial failure markers in pre-eclampsia Brain natriuretic peptide and N-terminal pro-BNP Seven studies reported on BNP levels, [78][79][80][81][82][83][84] of which three were applicable for a meta-analysis ( Figure 5). [78][79][80] In all seven studies and in meta-analysis, BNP levels were significantly higher in pre-eclampsia than in controls.…”

Section: Insulin Plasma Glucose and Fatty Acid-binding Proteinmentioning

confidence: 99%

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Shared biomarkers between female diastolic heart failure and pre‐eclampsia: a systematic review and meta‐analysis

et al. 2017

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Evidence accumulates for associations between hypertensive pregnancy disorders and increased cardiovascular risk later. The main goal of this study was to explore shared biomarkers representing common pathogenic pathways between heart failure with preserved ejection fraction (HFpEF) and pre‐eclampsia where these biomarkers might be potentially eligible for cardiovascular risk stratification in women after hypertensive pregnancy disorders. We sought for blood markers in women with diastolic dysfunction in a first literature search, and through a second search, we investigated whether these same biochemical markers were present in pre‐eclampsia.This systematic review and meta‐analysis presents two subsequent systematic searches in PubMed and EMBASE. Search I yielded 3014 studies on biomarkers discriminating women with HFpEF from female controls, of which 13 studies on 11 biochemical markers were included. Cases had HFpEF, and controls had no heart failure. The second search was for studies discriminating women with pre‐eclampsia from women with non‐hypertensive pregnancies with at least one of the biomarkers found in Search I. Search II yielded 1869 studies, of which 51 studies on seven biomarkers were included in meta‐analyses and 79 studies on 12 biomarkers in systematic review.Eleven biological markers differentiated women with diastolic dysfunction from controls, of which the following 10 markers differentiated women with pre‐eclampsia from controls as well: C‐reactive protein, HDL, insulin, fatty acid‐binding protein 4, brain natriuretic peptide, N terminal pro brain natriuretic peptide, adrenomedullin, mid‐region pro adrenomedullin, cardiac troponin I, and cancer antigen 125.Our study supports the hypothesis that HFpEF in women shares a common pathogenic background with pre‐eclampsia. The biomarkers representing inflammatory state, disturbances in myocardial function/structure, and unfavourable lipid metabolism may possibly be eligible for future prognostic tools.

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“…Seven studies reported on BNP levels,78, 79, 80, 81, 82, 83, 84 of which three were applicable for a meta‐analysis ( Figure 5). 78, 79, 80 …”

Section: Resultsmentioning

confidence: 99%

Section: Insulin Plasma Glucose and Fatty Acid-binding Proteinmentioning

confidence: 99%

Shared biomarkers between female diastolic heart failure and pre‐eclampsia: a systematic review and meta‐analysis

et al. 2017

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“…Although the actual pathways that may connect this biomarker to heart failure remain unclear, these pathways are somehow related to a concordant pattern of fluctuations with the B‐type natriuretic peptide (BNP) . This latter biomarker has been already implicated in the pathophysiology of preeclampsia …”

Section: Introductionmentioning

confidence: 99%

“…11 This latter biomarker has been already implicated in the pathophysiology of preeclampsia. 12,13 Taking this information together, it is easily assumed that CA-125 could be a promising biomarker that could be used for the detection of preeclampsia. During the last decade several studies investigated this association; however, the presented evidence is conflicting.…”

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confidence: 99%

Serum CA‐125 levels in preeclampsia: A systematic review and meta‐analysis

et al. 2019

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Background Preeclampsia is a leading cause of perinatal morbidity, although an optimal screening model is still under investigation. The aim of the present meta‐analysis is to accumulate current evidence and evaluate the diagnostic accuracy of CA‐125 in preeclampsia. Materials and Methods Medline, Scopus, CENTRAL, Clinicaltrials.gov and Google Scholar were systematically searched. All studies reporting serum CA‐125 among preeclamptic and healthy pregnant women were selected. Results Nine studies involving 977 women were included. Meta‐analysis revealed significant differences among patients with preeclampsia and control pregnant women (MD 15.86 IU/mL, 95% CI, 9.03‐22.69). Patients with severe preeclampsia had significantly higher levels of CA‐125 compared to patients with mild preeclampsia (MD 13.21 IU/mL, 95% CI, 1.94‐24.49). Meta‐regression analysis revealed that gestational age <34 weeks could positively affect this association. Conclusions The present meta‐analysis suggests that serum CA‐125 levels are increased in preeclamptic women during the third trimester of pregnancy. This association should be interpreted with caution as there are concerns for significant selection bias. Future studies are needed to corroborate these findings and investigate the diagnostic accuracy of this biomarker during early pregnancy.

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“…Vasopressin is synthesized and released together with co-peptine; compared to normal pregnancy, serum concentrations of co-peptine are higher in EPE but not LPE [41], and are already detectable before clinical onset of disease [42]. Similarly, serum concentrations of natriuretic peptides types A, B and C are higher in preeclampsia than in normal pregnancy, which is particularly true for EPE as compared to LPE [43,44,45,46,47].…”

Section: Renal Physiology In Normal Pregnancy and In Two Types Of mentioning

confidence: 99%

Maternal Venous Hemodynamic Dysfunction in Proteinuric Gestational Hypertension: Evidence and Implications

Gyselaers

2019

JCM

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This review summarizes current knowledge from experimental and clinical studies on renal function and venous hemodynamics in normal pregnancy, in gestational hypertension (GH) and in two types of preeclampsia: placental or early-onset preeclampsia (EPE) and maternal or late-onset (LPE) preeclampsia, presenting at <34 weeks and ≥34 weeks respectively. In addition, data from maternal venous Doppler studies are summarized, showing evidence for (1) the maternal circulation functioning closer to the upper limits of capacitance than in non-pregnant conditions, with intrinsic risks for volume overload, (2) abnormal venous Doppler measurements obtainable in preeclampsia, more pronounced in EPE than LPE, however not observed in GH, and (3) abnormal venous hemodynamic function installing gradually from first to third trimester within unique pathways of general circulatory deterioration in GH, EPE and LPE. These associations have important clinical implications in terms of screening, diagnosis, prevention and management of gestational hypertensive diseases. They invite for further hypothesis-driven research on the role of retrograde venous congestion in the etiology of preeclampsia-related organ dysfunctions and their absence in GH, and also challenge the generally accepted view of abnormal placentation as the primary cause of preeclampsia. The striking similarity between abnormal maternal venous Doppler flow patterns and those observed at the ductus venosus and other abdominal veins of the intra-uterine growth restricted fetus, also invites to explore the role of venous congestion in the intra-uterine programming of some adult diseases.

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Increased B-type natriuretic peptide levels in early-onset versus late-onset preeclampsia

Cited by 21 publications

References 37 publications

Shared biomarkers between female diastolic heart failure and pre‐eclampsia: a systematic review and meta‐analysis

Shared biomarkers between female diastolic heart failure and pre‐eclampsia: a systematic review and meta‐analysis

Serum CA‐125 levels in preeclampsia: A systematic review and meta‐analysis

Maternal Venous Hemodynamic Dysfunction in Proteinuric Gestational Hypertension: Evidence and Implications

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