Increased asthma and adipose tissue inflammatory gene expression with obesity and Inuit migration to a western country

Backer, Vibeke; Baines, Katherine J.; Powell, Heather; Porsbjerg, Celeste; Gibson, Peter G.

doi:10.1016/j.rmed.2015.12.003

Cited by 9 publications

(9 citation statements)

References 44 publications

(44 reference statements)

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“…MCs are increased in the white adipose tissue (WAT) of obese individuals, 46,47 and serum tryptase levels are increased in obese individuals 46 . MCs have been proposed as a potential cellular link between obesity and asthma, 48 although WAT MC‐related gene expression did not differ between asthma and non‐asthma in a study of Inuit residing in Denmark and Greenland, in contrast to IL‐6 mRNA which was increased in asthma WAT 49 . A link between obesity and airway MC activation in asthma may exist.…”

Section: Discussionsupporting

confidence: 84%

Relationship of sputum mast cells with clinical and inflammatory characteristics of asthma

Fricker

Qin

Niessen

et al. 2020

Clin Experimental Allergy

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Background: Mast cells (MCs) are innate immune cells that regulate atopic and nonatopic inflammation in the airways. MCs play a critical role in the pathogenesis of asthma, yet their relationship to airway and systemic inflammation and clinical characteristics of asthma is poorly understood. Objective: To quantify MCs in induced sputum samples and understand their relationship to airway and circulatory immune cells, and clinical variables in asthma. Methods: We employed flow cytometry of sputum samples to quantify MCs, basophils and other immune cells in 51 participants (45 asthma and 6 non-asthma controls). Relationship of MCs to airway (n = 45) and blood (n = 19) immune cells, participant demographics, asthma history, spirometry and airways hyperresponsiveness (AHR) to hypertonic saline was determined by correlation and comparison of cut-off-based sputum MC high vs low participants. Results: Mast cells, basophils and eosinophils were increased in asthma vs non-asthma control sputum. In asthma sputum, MCs, basophils and eosinophils were significantly intercorrelated, and MCs and basophils were elevated in participants with eosinophilic asthma. MCs and basophils, but not eosinophils, correlated with AHR. Sputum MC high asthma was characterized by an increased proportion of participants with uncontrolled asthma and reduced FEV 1 and FVC. Trends towards similar clinical associations with elevated MCs were observed in a paucigranulocytic subpopulation (n = 15) lacking airway eosinophilia or neutrophilia. Receiver operator characteristic (ROC) analysis showed peripheral blood eosinophil (PBE) count predicted elevated sputum eosinophils and basophils, but not MCs. Conclusions and Clinical Relevance: Sputum MCs are elevated in asthma, and their measurement may be useful as they relate to key clinical features of asthma (spirometry, asthma control, AHR). PBE count did not predict airway MC status, suggesting direct measurement of airway MCs by sensitive methods such as flow cytometry should be further developed. | 697 FRICKER Et al.

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Section: Discussionsupporting

confidence: 84%

Relationship of sputum mast cells with clinical and inflammatory characteristics of asthma

Fricker

Qin

Niessen

et al. 2020

Clin Experimental Allergy

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“…In contrast, in populations with higher intake of n-3 PUFAs, such as Inuits, asthma prevalence is significantly reduced [204][205][206]. Inuits are indigenous population of arctic and sub-arctic regions of Greenland, Canada and Alaska, whose diet is based mainly on fish and arctic marine mammals and hence is enriched with n-3 PUFAs [207]. Interestingly, there is an association between genotype and disease development in geographically separate Inuit populations-one living in Greenland and the other, migrated to Denmark [208].…”

Section: Asthmamentioning

confidence: 99%

“…↓ Risk of asthma, rhinitis and aeroallergen sensitization [200,204,220,221] ↓ Asthma symptoms scores and ↓ responsiveness to acetylcholine [222] Improvement in pulmonary functions and ↓ use of short-acting inhaled bronchodilators and inhaled corticosteroids [290] ↑ Prevalence of wheeze [248] Adulthood ↓ Prevalence of asthma symptoms, airway hyperresponsiveness and ↑ asthma control and lung function [47,202,206,207,224,[226][227][228]230,233] ↓ Exhaled nitric oxide, ↓ serum eosinophils and ↑ FEV1 [225,229] ↓ Bronchodilator use, ↓ exhale nitric oxide and ↓ severity of exercise-induced bronchoconstriction [228,[231][232][233] Allergic Rhinitis Infancy and childhood ↓ Risk of rhinitis development [251,[254][255][256] Adulthood ↓ Prevalence [257,258] Atopic Dermatitis Pregnancy and lactation ↓ Incidence and intensity in the offspring [259,260]…”

Section: Asthmamentioning

confidence: 99%

The Influence of Dietary Fatty Acids on Immune Responses

et al. 2019

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Diet-derived fatty acids (FAs) are essential sources of energy and fundamental structural components of cells. They also play important roles in the modulation of immune responses in health and disease. Saturated and unsaturated FAs influence the effector and regulatory functions of innate and adaptive immune cells by changing membrane composition and fluidity and by acting through specific receptors. Impaired balance of saturated/unsaturated FAs, as well as n-6/n-3 polyunsaturated FAs has significant consequences on immune system homeostasis, contributing to the development of many allergic, autoimmune, and metabolic diseases. In this paper, we discuss up-to-date knowledge and the clinical relevance of the influence of dietary FAs on the biology, homeostasis, and functions of epithelial cells, macrophages, dendritic cells, neutrophils, innate lymphoid cells, T cells and B cells. Additionally, we review the effects of dietary FAs on the pathogenesis of many diseases, including asthma, allergic rhinitis, food allergy, atopic dermatitis, rheumatoid arthritis, multiple sclerosis as well as type 1 and 2 diabetes.

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“…The authors measured several inflammatory cytokines and concluded that diet/lifestyle changes led to modification of adipose tissue inflammation leading to asthma. 49 This same group has also shown that an "arctic" diet is associated with higher lung function and adds to the evidence that diet, which is linked to ethnicity, may influence lung outcomes. 50 The role of breastfeeding remains controversial.…”

Section: Metabolic and Nutritional Factorsmentioning

confidence: 81%

Epidemiology of Asthma and Influence of Ethnicity

Moraes

Sears

Subbarao

2018

Semin Respir Crit Care Med

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Asthma is a heterogeneous disorder with a complex etiology. Prevalence rates for asthma have been increasing in many countries over the past few decades. While it is unclear why this increase is occurring, the variation reported in asthma prevalence and severity associated with ethnicity offers some insight into the determinants of asthma. In this chapter, we discuss the data linking asthma to ethnicity and some of the factors that may explain this association. These include socioeconomic status, environmental exposures, the host microbiome, and genetics. A better understanding of these processes may inform future mechanistic studies and identify modifiable risk factors for targeted health care interventions.

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Increased asthma and adipose tissue inflammatory gene expression with obesity and Inuit migration to a western country

Abstract: No association was found between gene expression of mast cell markers in adipose tissue and asthma. Among Greenlandic Inuit, adipose tissue inflammation is also increased in those who migrate to Denmark, possibly as a result of dietary changes.

Cited by 9 publications

References 44 publications

Relationship of sputum mast cells with clinical and inflammatory characteristics of asthma

Relationship of sputum mast cells with clinical and inflammatory characteristics of asthma

The Influence of Dietary Fatty Acids on Immune Responses

Epidemiology of Asthma and Influence of Ethnicity

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