Increased association of CD38 with lipid rafts in T cells from patients with systemic lupus erythematosus and in activated normal T cells

Pavón, Esther J.; Muñoz, Pilar; Navarro, María-del-Carmen; Raya-Álvarez, Enriqué; Callejas‐Rubio, José Luis; Navarro-Pelayo, Francisco; Ortego-Centeno, Norbérto; Sancho, Jaime; Zubiaur, Mercedes

doi:10.1016/j.molimm.2005.05.002

Cited by 23 publications

(32 citation statements)

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“…1B) and in agreement with previous reports (30,31). Furthermore, SLE patients also display a significant increase in CD4…”

Section: Kv13 Channels In T Lymphocytes From Patients With Sle Displsupporting

confidence: 93%

“…1C). This demonstrates that CD4 ϩ cells exist in a more active state in SLE patients as previously reported (31,32). Currently, nothing is known about the expression and activity of ion channels in T cells from patients with SLE.…”

Section: Kv13 Channels In T Lymphocytes From Patients With Sle Displsupporting

confidence: 82%

“…patients independent of their disease activity, thus suggesting a constant activation state of SLE T cells (6,31 ϩ and CD8 ϩ subsets, although it was higher in CD4 ϩ (5). Consistently, we showed that both CD4 ϩ and CD8 ϩ SLE T cells display faster dynamics of Kv1.3 translocation in and out of the IS.…”

Section: Discussionmentioning

confidence: 97%

“…We have conducted various studies aimed at dissecting the properties of K channels in SLE T cells. These studies were conducted on a cohort of SLE patients with a T cell phenotype characteristic of this disease as indicated by the low CD4-CD8 ratio (30,31). This low CD4-CD8 ratio might have been exacerbated by the presence of patients with lupus nephritis and patients under corticosteroid treatment (40).…”

Section: Discussionmentioning

confidence: 99%

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Altered Dynamics of Kv1.3 Channel Compartmentalization in the Immunological Synapse in Systemic Lupus Erythematosus

Nicolaou

Szigligeti

Neumeier

et al. 2007

The Journal of Immunology

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Aberrant T cell responses during T cell activation and immunological synapse (IS) formation have been described in systemic lupus erythematosus (SLE). Kv1.3 potassium channels are expressed in T cells where they compartmentalize at the IS and play a key role in T cell activation by modulating Ca2+ influx. Although Kv1.3 channels have such an important role in T cell function, their potential involvement in the etiology and progression of SLE remains unknown. This study compares the K channel phenotype and the dynamics of Kv1.3 compartmentalization in the IS of normal and SLE human T cells. IS formation was induced by 1–30 min exposure to either anti-CD3/CD28 Ab-coated beads or EBV-infected B cells. We found that although the level of Kv1.3 channel expression and their activity in SLE T cells is similar to normal resting T cells, the kinetics of Kv1.3 compartmentalization in the IS are markedly different. In healthy resting T cells, Kv1.3 channels are progressively recruited and maintained in the IS for at least 30 min from synapse formation. In contrast, SLE, but not rheumatoid arthritis, T cells show faster kinetics with maximum Kv1.3 recruitment at 1 min and movement out of the IS by 15 min after activation. These kinetics resemble preactivated healthy T cells, but the K channel phenotype of SLE T cells is identical to resting T cells, where Kv1.3 constitutes the dominant K conductance. The defective temporal and spatial Kv1.3 distribution that we observed may contribute to the abnormal functions of SLE T cells.

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“…1B) and in agreement with previous reports (30,31). Furthermore, SLE patients also display a significant increase in CD4…”

Section: Kv13 Channels In T Lymphocytes From Patients With Sle Displsupporting

confidence: 93%

Section: Kv13 Channels In T Lymphocytes From Patients With Sle Displsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Altered Dynamics of Kv1.3 Channel Compartmentalization in the Immunological Synapse in Systemic Lupus Erythematosus

Nicolaou

Szigligeti

Neumeier

et al. 2007

The Journal of Immunology

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“…35 The CD38 cell sur fa ce re cep tor is a po tent acti va tor for B lymphocy tes. In one re se arch of CD38 sig na ling which re gu la tes B lymphocy te ac ti va tion, it was de mons tra ted that CD38 ini ti a ted a novel sig na ling cas ca de le a ding to Btk-, phosp hatidyl cho li ne (PC)-me ta bo li zing enz ymes, (PC-PLC and phosp ho li pa se D), PC-PLC-, and phosp ho li pase D-de pen dent, PLC-gam ma2-in de pen dent, B lymphocy te ac ti va ti on.…”

mentioning

confidence: 99%

Evaluation of CD19+CD5+ B (B1) Lymphocytes and CD2 + CD38 Low Preplasmablast Cells in Patients with Behçet’s Disease

Kandı¹,

Ilhan²,

Çiçek³

et al. 2011

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : Beh cet's di se a se (BD) is a chro nic, re cur rent, inf lam ma tory di se a se. CD19+CD5+ B cells are cur rently de fi ned as B1 cells and they pro du ce pol yre ac ti ve an ti bo di es. CD20+CD38 low B cells can ca u se en dot he li al cell ad he si on and are res pon sib le for spe ci fic an tibody synthe sis. The aim of this study was to in ves ti ga te the pre sen ce of CD19+CD5+ B cells and B cells con ta i ning CD20+CD38 low mo le cu le, which plays a ro le in B cell dif fe ren ti a ti on and ac ti vati on. Mo re o ver, the ra ti o of the se cells in BD pa ti ents was al so eva lu a ted. M Ma a t te e r ri i a al l a an nd d M Me et t h ho od ds s: : In this study, 20 BD pa ti ents and 20 he althy con trol sub jects we re com pa red. Blo od samp les of the pati ents and the con trol gro up we re stained with stan dard pro ce du re using CD3, CD19, CD20, CD5, CD38 mo noc lo nal an ti bo di es with flow cyto met ric met hod, and B lymphocy te sub gro ups we re evalu a ted. R Re e s su ul lt ts s: : The re we re no sig ni fi cant dif fe ren ces bet we en to tal T and B lymphocy te ra ti os of two gro ups. Ho we ver, CD19+CD5+ B lymphocy tes and CD20+CD38 low prep las mab lasts we re signi fi cantly hig her in BD pa ti ents com pa red to the con trol gro up. C Co on nc c l lu u s si i o on n: : It was de ter mi na ted that high le vels of CD20+CD38low and CD19+CD5+ B lymphocy tes in BD con cerns the pos sib le role of hu mo ral im mu nity or for ce of T cell in de pen dent res pon se. On the ot her hand, im me di a te dif fe ren ti a ti on of IgM pro du cing cells in di ca tes B cell ac ti va ti on and all the ot hers sup port the possib le ro le of CD38 in the eti o logy of vas cu li tis, which is the unc han ge ab le cha rac te ris tic and the basis of de fi ning BD as an au to inf lam ma tory di se a se.K Ke ey y W Wo or rd ds s: : Behçet syndrome; B-lymphocytes; lymphocytes Ö ÖZ ZE ET T A Am ma aç ç: : Beh çet has ta lı ğı (BH), kro nik, tek rar la yı cı, inf lam ma tu ar bir has ta lık tır. CD19+CD5+ B hüc re le ri ya kın za man da B1 hüc re le ri ola rak ta nım lan mış ve çok ya nıt lı an ti kor lar üret mek tedir ler. CD20+CD38 dü şük B hüc re le ri, en do tel yal hüc re ad hez yo nu na ne den ola bil mek te dir ve spe si fik an ti kor sen te zin den so rum lu dur lar. Bu ça lış ma nın ama cı, B hüc re fark lı laş ma sın da ve akti vas yo nun da rol alan CD19+CD5+ B hüc re le ri ni ve CD20+CD38 dü şük mo le kül içe ren B hüc rele ri ni araş tır mak tı. Ay rı ca, bu hüc re le rin BH'li has ta lar da ki ora nı nı de ğer len dir mek ti. G Ge e r re eç ç v ve e Y Yö ön n t te em m l le er r: : Bu ça lış ma da BH'li 20 has ta ve sağ lık lı 20 kon trol ol gu su kar şı laş tı rıl mış tır. Has ta la rın ve sağ lık lı kon trol gru bu nun kan la rı, flow si to met rik me tod la CD3, CD19, CD20, CD5, CD38 monok lo nal an ti kor lar kul la nı la rak stan dart yön tem ler le bo yan mış ve B len fo sit alt grub la rı de ğer -len di ril miş tir. B Bu ul l g...

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Immune Receptor Signaling, Aging and Autoimmunity

Larbi

Fülöp

Pawelec

Advances in Experimental Medicine and Biology

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Aging is associated with a myriad of changes including alterations in glucose metabolism, brain function, hormonal regulation, muscle homeostasis and the immune system. Aged dividuals, generally still defined as over 65 years old, differ from middle-aged or young donors in many features of the immune system. The major observation is that the elderly population is not able to cope with infections as well as younger adults and recovery generally takes longer. Moreover, some diseases first appear with advancing age and are likely associated with dysfunction of the immune system. Thus, Alzheimer's disease, atherosclerosis, type II diabetes and some autoimmune disorders are linked to changes in immune function. One major immune cell population implicated as being responsible for the initiation and chronicity of immune dysfunction leading to diseases or immunosuppression is the T-cell. Although many changes in B-cell and innate immune function in aging are associated with the appearance of disease, they are not as well studied and clearly demarcated as changes in the T-cell compartment. The adaptive immune system is coordinated by T-cells, the activation of which is required for the initiation, maintenance and termination of responses against pathogens. Changes in the expression and functions of the T-cell receptor (TCR) for antigen and its co-receptors are closely associated with immunosenescence. Certain similar changes have also been found in some other disease states, e.g., rheumatoid arthritis, systemic lupus erythematosus and cancer. In this chapter, we will summarize our knowledge about multichain immune recognition receptor signaling, mainly the TCR, in aging and autoimmune diseases.

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Increased association of CD38 with lipid rafts in T cells from patients with systemic lupus erythematosus and in activated normal T cells

Cited by 23 publications

References 50 publications

Altered Dynamics of Kv1.3 Channel Compartmentalization in the Immunological Synapse in Systemic Lupus Erythematosus

Altered Dynamics of Kv1.3 Channel Compartmentalization in the Immunological Synapse in Systemic Lupus Erythematosus

Evaluation of CD19+CD5+ B (B1) Lymphocytes and CD2 + CD38 Low Preplasmablast Cells in Patients with Behçet’s Disease

Immune Receptor Signaling, Aging and Autoimmunity

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