Increased arterial stiffness in healthy young South Asian men

Din, Jehangir; Ashman, O.; Aftab, Syed; Jubb, Alasdair; Newby, David E.; Flapan, Andrew D.

doi:10.1038/sj.jhh.1001961

Cited by 19 publications

(22 citation statements)

References 14 publications

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“…In white Europeans, the extent of the arterial stiffness appears to correlate with conventional CHD risk factor burden [25]. In South Asians, there seems to be a considerable variation in the magnitude of impact on the arterial wall characteristics [27]. In the current study, South Asians were demonstrated to have a greater arterial stiffness for a given blood pressure category after adjusting for other comorbidities including age.…”

Section: Discussionmentioning

confidence: 84%

Impact of mean arterial blood pressure on higher arterial stiffness indices in South Asians compared to white Europeans

Gunarathne

Patel²,

Gammon³

et al. 2008

Journal of Hypertension

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Section: Discussionmentioning

confidence: 84%

Impact of mean arterial blood pressure on higher arterial stiffness indices in South Asians compared to white Europeans

Gunarathne

Patel²,

Gammon³

et al. 2008

Journal of Hypertension

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“…healthy 20 and poststroke 21 SA subjects compared with their European counterparts. Neither measured aPWV.…”

Section: Discussionmentioning

confidence: 99%

Ethnic Differences in Aortic Pulse Wave Velocity Occur in the Descending Aorta and May Be Related to Vitamin D

et al. 2011

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Abstract-We studied aortic pulse wave velocity (aPWV), a predictor of cardiovascular events independent of blood pressure, in a multiethnic sample of British men, to investigate the roles for blood levels of vitamin D and aldosterone in total and regional aortic stiffness. Total aPWV was estimated noninvasively by the Arteriograph device (aPWV AG ) in 198 men, with its length measure calibrated by magnetic resonance. PWVs over the aortic arch and descending aorta were measured by magnetic resonance in a subsample (nϭ47). Mean (SE) aPWV AG in South Asians (nϭ68; age 55Ϯ10 years), at known higher coronary disease risk than other groups, was 0.5 m/s (0.2 m/s) higher than in African Caribbeans (nϭ67; 55Ϯ10 years), at lowest coronary disease risk here, and Europeans (nϭ63; 57Ϯ8 years), adjusted for age, systolic blood pressure, and diabetes mellitus (Pϭ0.01). By magnetic resonance, PWV over the descending aorta in South Asians was 0.7 m/s (0.3 m/s) and 0.8 m/s (0.3 m/s) higher than in African Caribbeans and Europeans, respectively; PWV over the aortic arch was not different. South Asians and African Caribbeans had 21 nmol/L (3 nmol/L) and 14 nmol/L (3 nmol/L) lower mean (SE) 25(OH)D than Europeans (PϽ0.001). Unlike aldosterone, 25(OH)D was negatively correlated with aPWV AG adjusted for age and systolic blood pressure, as well as weakened or removed ethnic differences in aPWV AG in regression models. These data suggest that aortic stiffness as aPWV parallels coronary disease risk in ethnic groups, descending aortic but not arch PWV has this feature, and serum 25(OH)D is an independent negative correlate of aPWV and may partly account for ethnicity-related differences in aPWV and coronary disease risk.

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“…1,2) Dietary n-3 fatty acids are considered to prevent heart disease through a variety of actions that are linked to the prevention of arrhythmias, eicosanoid-mediated effects, antiinflammatory properties, inhibitions of cytokine and mitogen synthesis, stimulation of endothelial-derived nitric oxide formation, antithrombotic action, hypolipidemic properties and ultimately inhibition of atherosclerosis. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) together constitute about 26% of fish oil fatty acids, and these n-3 polyunsaturated fatty acids are considered to be the critical components in protecting against coronary heart disease.…”

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confidence: 99%

Effects of Supplemented Diacylglycerol Rich in Docosahexaenoic Acid on Serum Triacylglycerol in a Diet-Induced Hyperlipidemic Model of Rats Are Essentially Equivalent to Those of Triacylglycerol Rich in Docosahexaenoic Acid

Tamai

Murota

Maruyama

et al. 2007

Biological & Pharmaceutical Bulletin

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Effects of supplemented docosahexaenoic acid (DHA), given as diacylglycerol (DG) rich in DHA (DHA-DG), triacylglycerol (TG) rich in DHA (DHA-TG) or fish oil concentrate (DHA-70), on the serum concentration of TG and its bioavailability in the rats with diet-induced hyperlipidemia were studied. Hypertriglyceridemia was induced by feeding male Wistar rats a semi-purified diet that contained 5% corn oil and 50% sucrose by weight. In addition to the feeding of dietary corn oil, the rats received DHA intragastrically at a dose of 500 mg/kg body weight once a day for 28 d and the control rats were given olive oil. The serum concentration of TG in the rats that received DHA-DG was significantly lower than in the control rats. However, there were no significant differences in diet intake, energy intake, body weight gain, visceral fat mass or fecal excretion of total fatty acids among the four groups. The amounts of DHA excreted into the feces of the three groups of rats that received DHA were approximately 0.4% of the DHA administered. The extent of the decreases induced by DHA-DG in the serum level of TG was almost the same as those induced by DHA-TG and DHA-70. The administration of DHA, regardless of the differences in molecular structure, did not affect the hepatic contents of TG or phospholipid. The administration of DHA-DG considerably increased the proportions of DHA and eicosapentaenoic acid (EPA) while decreasing the proportion of arachidonic acid in hepatic lipids, and as a result in the lipids in serum and erythrocytes, to the same extents as did DHA-TG and DHA-70. These results suggest that the hypotriglyceridemic effects and bioavailability of DHA when supplemented in the form of DG are essentially equivalent to those of DHA-TG and DHA-70.Key words docosahexaenoic acid; diacylglycerol; triacylglycerol; hypolipidemic effect; rat Biol. Pharm. Bull. 30(12) 2381-2388 (2007) © 2007 Pharmaceutical Society of Japan * To whom correspondence should be addressed. e-mail: t-tamai@maruha.co.jp DHA. The aims of this study are to compare the effects of DHA on serum TG level and the bioavailability of DHA supplemented as DG rich in DHA with those of TG rich in DHA. Test Oils DHA-concentrated oil whose content of DHA was over 70% , estimated as fatty acid composition, was prepared by the Central Research Institute of Maruha Group Inc. MATERIALS AND METHODS Materials(as the product name of DHA-70). DHA-DG and DHA-TG were separated from DHA-70 using molecular distillation and chromatography.17) The contents of DHA in these oils were quantified by gas chromatography, and the results showed that the contents of DHA in DHA-DG, DHA-TG and DHA-70 were 689, 497 and 593 mg/g, respectively. The DG was composed of 1,3-DG and 1,2-DG at a ratio of 67.8 : 31.8, as determined by thin-layer chromatography with a flame ionization detector (IATROSCAN MK-6, Mitsubishi Kagaku Iatron Inc., Tokyo, Japan). The gravities of DHA-DG, DHA-TG and DHA-70 were 0.99, 0.98 and 0.96, respectively. The amounts of these oils to be administered to rats ...

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Increased arterial stiffness in healthy young South Asian men

Cited by 19 publications

References 14 publications

Impact of mean arterial blood pressure on higher arterial stiffness indices in South Asians compared to white Europeans

Impact of mean arterial blood pressure on higher arterial stiffness indices in South Asians compared to white Europeans

Ethnic Differences in Aortic Pulse Wave Velocity Occur in the Descending Aorta and May Be Related to Vitamin D

Effects of Supplemented Diacylglycerol Rich in Docosahexaenoic Acid on Serum Triacylglycerol in a Diet-Induced Hyperlipidemic Model of Rats Are Essentially Equivalent to Those of Triacylglycerol Rich in Docosahexaenoic Acid

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