Increased arterial stiffness in cyclosporine‐treated lung transplant recipients early after transplantation

Abstract

Forearm blood flow and arterial resistance did not differ between healthy subjects and cyclosporine-treated lung transplant recipients early after transplantation. Increased arterial stiffness was demonstrated in transplant recipients, which may have implications for future development of transplant hypertension.

Blunted Vascular Response to Endothelin-A Receptor Blockade in Cyclosporine-Treated Lung Transplant Recipients

“…9 -13 There is also evidence for an increased vascular resistance in transplant recipients with hypertension, 21,22 although contradictory reports exist. 20,23 However, our results did not support our hypothesis. We found no evidence for an increased basal vascular resistance between cyclosporine-treated transplant recipients and healthy controls.…”

“…1,3,19 The higher prevalence for heart transplant recipients has been blamed on heart denervation and a higher prevalence of preexisting vascular disease before transplantation. 3,19 In the present investigation, we decided to include only lung transplant recipients without manifest hypertension because this group has a low incidence of pretransplantation vascular dysfunction 19,20 and we wanted to discriminate between the vascular effects of chronic CsA treatment and hypertension per se.…”

Vascular resistance and endothelial function in cyclosporine-treated lung transplant recipients

“…Whether this is a generalized effect in all vascular beds has previously been questioned by Bracht et al [11], who found lower FVR despite higher blood pressure in heart recipients late after transplantation. In addition, in two recent studies, we found no evidence of increased FVR in lung transplant recipients [9,10]. However, those latter investigations were performed in lung recipients within 18 month after transplantation and without hypertension, and it is possible that vasoconstriction and increased FVR occur later.…”

“…It is unclear if all vascular beds contribute to the increased systemic vascular resistance. Our group and others have presented data that questions the presence of increased skeletal muscle vascular resistance in CsA treated lung and heart transplant recipients [9–11]. However, our investigations were performed relatively early after transplantation (1–18 month) in lung recipients without manifest hypertension.…”

Cyclosporine A-induced acute hepatotoxicity in guinea pigs is associated with endothelin-mediated decrease in local hepatic blood flow

“…Nakache et al (1999) have reported that CsA increases the vascular resistance in the liver through an acute mechanism. Besides, it has been shown that CsA leads to arterial stiffness in transplant recipients early after transplantation (Silverborn et al 2004). In order to elucidate whether or not the afore-mentioned acute effect of CsA administration on LHBF is mediated by an ET-1-related process, we pre-treated the animals with bosentan, a nonselective ET receptor antagonist, and BQ-123, a selective ET A receptor antagonist.…”