Increased Arsenic Concentration in the Bone Marrow in Chronic Renal Failure – A Contributor to Anaemia ?

Pershagen, Göran; Hast, Robert; Lins, Lars‐Eric; Pehrsson, Kenneth

doi:10.1159/000182477

Cited by 12 publications

(6 citation statements)

References 6 publications

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“…Mayer et al, found decreased arsenic levels in 85 patients who were suffering from renal failure and undergoing haemodialysis treatment [22]. Higher arsenic (As) concentrations have been reported in the blood and bone marrow of patients with renal failure [23,24]. In healthy subjects, arsenic is usually excreted in urine and it is removed to a certain extent by haemodialysis; however, the removal of arsenic by haemodialysis may not be sufficient, thus leading to its accumulation in the body of haemodialysis patients [25][26][27].…”

Section: Resultsmentioning

confidence: 99%

Blood Arsenic and Cadmium Concentrations in End-Stage Renal Disease Patients who were on Maintenance Haemodialysis

Palaneeswari

Pm²,

Silambanan³

et al. 2013

JCDR

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Background: In India, there is a rising burden of chronic diseases like hypertension and diabetes. It has been estimated that 25-40% of these patients are likely to develop chronic kidney disease (CKD), with a significant percentage requiring renal replacement therapy. Haemodialysis is the most common method which is used to treat advanced and permanent kidney failure. Derangements in the metabolism of several toxic and trace elements such as antimony, arsenic cadmium, molybdenum, nickel, and selenium have been reported for several decades in patients with chronically reduced renal functions. Overall, the available literature suggests that the blood levels of some elements such as cadmium, chromium, fluorine, iodine, lead, or vanadium are high in end-stage renal disease (ESRD). Aim and Objectives:Our aim was to study the levels of blood arsenic and cadmium in ESRD patients who were on maintenance haemodialysis (MHD), and to study whether there was any relationship between their concentrations and the duration of the MHD. Methods:The blood lead levels were determined in 50 healthy subjects with normal renal functions and in 50 patients with ESRD, who were on MHD. None of them had any history of smoking or any industrial exposure. Results:The results of the study revealed that the blood arsenic and cadmium concentrations were higher in the ESRD patients who were on MHD than in the healthy adults. The blood arsenic and cadmium concentrations were found to increase with the duration of the MHD. Conclusion:The mild increase in the blood arsenic and cadmium concentrations, with an increase in the duration of the MHD in the study population, may be viewed in the wider context, that a prolonged exposure to arsenic and cadmium, even at low levels, may result in renal damage and/or progression of an already existing CKD.

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Section: Resultsmentioning

confidence: 99%

Blood Arsenic and Cadmium Concentrations in End-Stage Renal Disease Patients who were on Maintenance Haemodialysis

Palaneeswari

Pm²,

Silambanan³

et al. 2013

JCDR

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“…Higher As concentrations have also been reported in blood and bone marrow from patients with renal failure [27,28]. In healthy subjects, As is usually excreted in urine [3,29] and is removed to a certain extent by hemodialysis [30].…”

Section: Discussionmentioning

confidence: 99%

Trace Elements in the Hair of Hemodialysis Patients

Ochi

Ishimura

Tsujimoto

et al. 2011

Biol Trace Elem Res

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Trace element disturbance is often observed in hemodialysis patients. While trace element concentrations have been reported in blood samples from hemodialysis patients, they have not been well investigated in scalp hair. In the present study, 22 trace elemental concentrations were measured by inductively coupled plasma-atomic emission spectrometry in the scalp hair of 80 male hemodialysis patients and compared with those of 100 healthy male subjects. In hemodialysis patients, the concentrations of beryllium, arsenic, magnesium, chromium, manganese, iron, selenium, molybdenum, iodine, vanadium, and cobalt were significantly higher than those in healthy subjects, while lead, mercury, copper, germanium, and bromine were significantly lower than those in the former group. No significant differences were observed for lithium, aluminum, cadmium, zinc, boron, or nickel. There were significant positive correlations between the duration of hemodialysis and the magnesium and manganese concentrations. There was a significant negative correlation between cadmium concentration and the duration of hemodialysis. There were significant positive correlations between dialysis efficacy (Kt/V) and magnesium, manganese, zinc, and selenium concentrations. In conclusion, trace element concentrations of the scalp hair are different between hemodialysis patients and healthy subjects. Essential trace elements, such as magnesium, manganese, zinc, and selenium, may be affected by the duration of hemodialysis and Kt/V.

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“…Arsenic was found to be either removed [115] or unaltered after HD [114]. Accumulation of arsenic may contribute to anemia in uremic patients [116]. However, extreme arsenic deficiency was suggested to contribute to the increased death risk of HD patients [113].…”

Section: Arsenic Cadmium Vanadiummentioning

confidence: 99%

Trace Elements in End-Stage Renal Disease

Zima¹,

Tesař²,

Mestek

et al. 1999

Blood Purif

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For human beings trace elements are essential nutrients with a gamut of functions. They are for instance indispensable components of many enzymes, so they have some regulatory functions and they may affect immune reactions and free radical generation. Abnormalities of trace elements are primarily the result of uremia, and they may be further modified and sometimes greatly exacerbated by the dialysis procedure. The role of trace elements in hemodialysis (HD) patients has not yet been fully characterized. To prevent some complications in chronic HD patients, it is very important to regulate the levels of trace elements by adequate water treatment. Reverse osmosis is able to prevent the accumulation of the majority of trace elements in the patients. Zinc supplementation may be recommended for patients with proven zinc deficiency, but for all chronic renal failure patients it is questionable. Selenium deficiency is to be suspected in dialyzed patients and selenium supplementation may be beneficial (increasing glutathione peroxidase activity, cardioprotective effect, immunostimulatory properties) for chronic renal failure patients. Supplementation with a trace element may be indicated when its depletion was unequivocally documented and when there is evidence of the positive effects of this element on the quality of life of the dialyzed patients.

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Increased Arsenic Concentration in the Bone Marrow in Chronic Renal Failure – A Contributor to Anaemia ?

Abstract: An increased level of arsenic has been found in the bone marrow of 5 non-dialyzed patients with chronic renal failure. Intoxication with inorganic arsenic can cause anaemia, and accumulation of arsenic may contribute to the anaemia in uraemic patients.

Cited by 12 publications

References 6 publications

Blood Arsenic and Cadmium Concentrations in End-Stage Renal Disease Patients who were on Maintenance Haemodialysis

Blood Arsenic and Cadmium Concentrations in End-Stage Renal Disease Patients who were on Maintenance Haemodialysis

Trace Elements in the Hair of Hemodialysis Patients

Trace Elements in End-Stage Renal Disease

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