Increased Apoptosis in the Contralateral Testes of Patients With Testicular Torsion as a Factor for Infertility

Hadžiselimović, F.; Geneto, R.; Emmons, Lyman R.

doi:10.1016/s0022-5347(01)62725-3

Cited by 66 publications

(14 citation statements)

References 20 publications

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“…The trauma to the blood-testis barrier initiated by testicular torsion induces the release of apoptotic activating factors (cytokines), which subsequently cause extensive apoptosis in the germinal epithelium of the contralateral testis. Therefore, it is probable that repeat apoptotic episodes may explain the high incidence of infertility in these patients [22]. the decline in the testicular membrane constituents, protein and phospholipid, content in the present study lend support to this contention.…”

Section: Discussionsupporting

confidence: 78%

“…The formation of multinucleated cells, constituted by young spermatids have been shown in another study [22], similar observations in rats using D-thio-glucose were reported earlier [23]. This is a compound that interferes with glucose metabolism [24].…”

Section: Discussionsupporting

confidence: 75%

“…Attempts at grading the severity of testicular injury after torsion have used such general parameters as fertility rates [6], testicular size, testicular weight, testicular histology [7], and semen analyses [8]. The results, however, have been conflicting.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Testicular Torsion-Detorsion- Histological and Biochemical Changes in Rat Testis

Fa¹,

Elfagih²,

Sheriff³

et al. 2012

J Cytol Histol

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Section: Discussionsupporting

confidence: 78%

Section: Discussionsupporting

confidence: 75%

See 1 more Smart Citation

Testicular Torsion-Detorsion- Histological and Biochemical Changes in Rat Testis

Fa¹,

Elfagih²,

Sheriff³

et al. 2012

J Cytol Histol

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“…It is believed that apoptosis plays an important role in the removal of overproduced, genetically abnormal, or accidentally damaged germ cells. Furthermore, increases in germ cell apoptosis are observed in laboratory animals after exposure to various testicular toxicants [3,4] as well as in human after testicular injury or under certain disease conditions [5,6].…”

Section: Introductionmentioning

confidence: 99%

Enhancement of germ cell apoptosis induced by ethanol in transgenic mice overexpressing Fas Ligand

Jiang

Hua

et al. 2003

Cell Res

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It was suggested that chronic ethanol exposure could result in testicular germ cell apoptosis, but the mechanism is still unclear. In the present study, we use a model of transgenic mice ubiquitously overexpressing human FasL to investigate whether Fas ligand plays a role in ethanol-induced testicular germ cell apoptosis. Both wild-type (WT) mice and transgenic (TG) mice were treated with acute ethanol (20% v/v) by introperitoneal injection for five times. After ethanol injection, WT mice displayed up-regulation of Fas ligand in the testes, which was shown by FITCconjugated flow cytometry and western blotting. Moreover, TG mice exhibited significantly more apoptotic germ cells than WT mice did after ethanol injection, which was demonstrated by DNA fragmentation, PI staining flow cytometry and TUNEL staining. In addition, histopathological examination revealed that degenerative changes of epithelial component of the tubules occurred in FasL overexpressing transgenic mice while testicular morphology was normal in wild-type mice after acute ethanol exposure, suggesting FasL expression determines the sensitivity of testes to ethanol in mice. In summary, we provide the direct evidences that Fas ligand mediates the apoptosis of testicular germ cells induced by acute ethanol using FasL transgenic mice.

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“…In an earlier pathological study on the contralateral testis following unilateral testicular torsion [8][9][10], Hadziselimovic et al [8] found apoptosis of germ cells, uneven distribution of the seminiferous tubules, and extensively reduced numbers of spermatogenic cells. Rodriguez et al [11] studied the immunohistopathological changes in the contralateral testis of rats after spermatic cord torsion, and the results suggested humoral and cellular immune-mediated testicular cell damage of the contralateral testis.…”

Section: Discussionmentioning

confidence: 99%

Blood perfusion of the contralateral testis evaluated with contrast-enhanced ultrasound in rabbits with unilateral testicular torsion

Chen

Zhan²,

Zhang³

et al. 2009

Asian J Androl

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The changes of blood perfusion of contralateral testis after unilateral testicular torsion remain controversial. In this study, 28 New Zealand white male rabbits were randomly divided into five groups. Group A (n = 8), the control group, underwent a sham operation on the unilateral testis without inducing testicular torsion. In groups B, C, and D (n = 5 each), unilateral testicular torsion was induced, and, after 3, 6 or 24 h, respectively, detorsion was performed. In group E (n = 5), permanent unilateral testicular torsion was applied. Contrast-enhanced ultrasound was used to observe the blood perfusion of the contralateral testis at the following stages: pre-torsion (preopration), immediately post-torsion (postopration), pre-detorsion, immediately post-detorsion, and late-stage post-detorsion (6-12 h post-detorsion in groups B-D) or at a similar time point (15-21 h post-torsion in group E). Time-intensity curves were generated, and the following parameters were derived and analyzed: arrival time, time to peak intensity, peak intensity, and half-time of the descending peak intensity. The analysis revealed that blood perfusion of the contralateral testis increased immediately after testicular torsion on the opposite side (P < 0.05), which increased with prolonged testicular torsion of the other testis. This research demonstrated that contrast-enhanced ultrasound was valuable in evaluating blood perfusion of the contralateral testis after unilateral testicular torsion.

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Increased Apoptosis in the Contralateral Testes of Patients With Testicular Torsion as a Factor for Infertility

Cited by 66 publications

References 20 publications

Testicular Torsion-Detorsion- Histological and Biochemical Changes in Rat Testis

Testicular Torsion-Detorsion- Histological and Biochemical Changes in Rat Testis

Enhancement of germ cell apoptosis induced by ethanol in transgenic mice overexpressing Fas Ligand

Blood perfusion of the contralateral testis evaluated with contrast-enhanced ultrasound in rabbits with unilateral testicular torsion

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