Increased Antioxidant Activity and Changes in Phenolic Profile of <i>Kalanchoe pinnata</i> (Lamarck) Persoon (Crassulaceae) Specimens Grown Under Supplemental Blue Light

Nascimento, Luana Beatriz S.; Leal-Costa, Marcos Vinícius; Coutinho, Marcela Araújo Soares; Moreira, Nattacha dos Santos; Lage, Celso Luiz Salgueiro; Barbi, Nancy dos S.; Costa, Sônia Soares; Tavares, Eliana Schwartz

doi:10.1111/php.12006

Cited by 72 publications

(41 citation statements)

References 61 publications

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“…Many flavonoids have been previously described in this species, including the compounds isolated in this study (Muzitano et al, 2006a(Muzitano et al, , 2006bTatsimo et al, 2012). The literature reports that compound 1 (diglycosylated flavonoid) showed antiallergic actions (Ichikawa, Ogura, Lijima, 1986), high antioxidant potential (Nascimento et al, 2013) and antileishmanial activities (Muzitano et al, 2006a). Moreover, quercetrin (2) protected skin from UVB-induced inflammation (Yin et al, 2013), displayed antioxidant (Aderogba, Okoh, Idowu, 2005;Tai et al, 2014) and antileishmanial activities (Muzitano et al, 2006b), showed antiproliferative and apoptotic effects in colon cancer cells (Cincin et al, 2015), demonstrated gastroprotective actions (Mota et al, 2009) and showed intestinal anti-inflammatory effects (Camuesco et al, 2004).…”

Section: Resultsmentioning

confidence: 69%

Gastroprotective activity of the hydroethanolic extract and ethyl acetate fraction from Kalanchoe pinnata (Lam.) Pers.

Sobreira

Hernandes

Vetore-Neto

et al. 2017

Braz. J. Pharm. Sci.

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Peptic ulcers are an important pathology, and the search for safer and more effective treatment methods is of paramount importance. In this study, we assess the gastroprotective effects of the hydroethanolic extract (HE) and ethyl acetate fraction (EAF) from Kalanchoe pinnata leaves against an ethanol/HCl-induced ulcer model in rats. The HE reduced gastric lesions by approximately 47% (400 mg/kg). A significant inhibition of the gastric lesions by 50% was observed after pretreatment with the EAF (200 mg/kg). Quercetrin and quercetin 3-O-α-L-arabinopyranosyl-(1→2)-α-L-rhamnopyranoside were isolated and identified in the flavonoid fraction (EAF) by HPLC and NMR analyses because this fraction showed the highest gastroprotective effect. This fraction demonstrated high antioxidant activities (CE 50 =41.91 µg/mL) by DPPH in comparison with Trolox ® and 11.33 mmol Trolox ® equivalent by ORAC. In conclusion, the HE and FAE from K. pinnata displayed gastroprotective activity in rats, most likely due to the presence of flavonoids.Uniterms: Gastric ulcer/study/rats. Gastric ulcer/treatment. Kalanchoe pinnata/chromatographic profile. Kalanchoe pinnata/gastroprotective activity. Quercetrin. Quercetin 3-O-α-L-arabinopyranosyl-(1→2)-α-L-rhamnopyranoside. INTRODUCTIONFor the past two centuries, peptic ulcers have caused high morbidity and mortality (Malfertheiner, Chan, Mccoll, 2009). This disease is a serious and prevalent pathology (Calam, Baron, 2001). A peptic ulcer is a chronic lesion, usually single, that can be located in the gastric or duodenal mucosae (Kumar, Abbas, Fausto, 2005). In the UK, the incidence of this disease was 12% higher in men than in women (Araujo, Borini, Guimarães, 2014). A review article (January 1980 to February 2009 showed that the incidence rate of uncomplicated peptic ulcers was approximately one case per 1000 people per year in the general population; the incidence rate for complicated peptic ulcers that included bleeding and perforation was approximately 0.7 cases per 1000 people per year (Lin, Rodrígues, Hernándes-Diaz, 2011).The pathophysiology of peptic ulcers suggests that this disease is caused by an imbalance between defensive factors (mucus and bicarbonate secretion, mucosal barrier, blood flow, and prostaglandins) and destructive factors (reactive oxygen species and acid and pepsin secretion), resulting in the acute inflammation of the gastrointestinal mucosae (Laine, Takeuchi, Tarnawski, 2008). Several stimuli serve as offensive factors, including Helicobacter pylori, the use of nonsteroidal anti-inflammatory drugs (NSAIDs), stress, alcohol and cigarette smoking (Malfertheiner, Chan, Mccoll, 2009;Malnick et al., 2014). The current medical treatment for peptic ulcers is generally based on proton pump inhibitors and histamine H 2 -receptor blockers (Jain et al., 2007). However, the long-term use of these therapeutic agents can produce adverse effects, such as hypergastrinemia and hyperplasia in the enterochromaffinlike (ECL) cells, the risk of pneumonia, diarrhea and the disturbance of ...

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Section: Resultsmentioning

confidence: 69%

Gastroprotective activity of the hydroethanolic extract and ethyl acetate fraction from Kalanchoe pinnata (Lam.) Pers.

Sobreira

Hernandes

Vetore-Neto

et al. 2017

Braz. J. Pharm. Sci.

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“…Particularly active were α-rhamnoisorobin (23) (IC 50 = 0.71 µg/mL) [28] and quercetin 3-O-α-L-arabinopyranosyl-(1 → 2)-α-L-rhamnopyranoside (29) (EC 50 = 1.41 µg/mL) [90].…”

Section: Antioxidant Activitymentioning

confidence: 99%

Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy

et al. 2016

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ReviewsThis document was downloaded for personal use only. Unauthorized distribution is strictly prohibited.Bryophyllum (see below) [4]. While these reviews describe various compounds and bioactivities, none of them addresses the pharmacological and clinical data that support the therapeutic use of Bryophyllum preparations in European countries. The present review focuses on B. pinnatum, but the few data available on Bryophyllum daigremontianum, Bryophyllum delagoense, and the hybrid Bryophyllum daigremontianum x tubiflorum have also been included. The German homeopathic pharmacopeia (HAB) 2014 [5] lists the two species B. pinnatum and B. daigremontianum as officinal in its monography "Bryophyllum Rh", and both have been used in AM. B. delagoense was introduced in the 1980s as an anthroposophic medicinal product in Germany, primarily for sedative purposes (Personal communication, Dr. med. Siegward-M. Elsas, see Acknowledgments). Botany

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“…Hence, blue (B) and red (R) LED light absorbed by photosynthetic pigments are more effective than other wide-spectrum light [6]. B light is associated with physiological responses such as plant photo-morphogenesis, phototropism, vegetative growth, stomatal opening, leaf expansion, anatomy and photosynthetic functioning, enzyme synthesis, chloroplast movement, and gene expression [6][7][8][9][10][11]. The range of wavelengths of B light impacting growth of plants is diverse and crop-specific [10,12].…”

Section: Introductionmentioning

confidence: 99%

Response of Eustoma Leaf Phenotype and Photosynthetic Performance to LED Light Quality

2017

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Abstract:In a controlled environment, light from light-emitting diodes (LEDs) has been associated with affecting the leaf characteristics of Eustoma. LEDs help plant growth and development, yet little is known about photosynthetic performance and related anatomical features in the early growth stage of Eustoma leaves. In this study, we examined the effects of blue (B), red (R), and white (W) LEDs on the photosynthetic performance of Eustoma leaves, as well as leaf morphology and anatomy including epidermal layer thickness, palisade cells, and stomatal characteristics. Leaves grown under B LEDs were thicker and had a higher chlorophyll content than those grown under the R and W LEDs. Leaves under B LEDs had greater net photosynthetic rates (A), stomatal conductance (g s ), and transpiration rates (E), especially at a higher photon flux density (PPFD), that resulted in a decrease in the intercellular CO 2 concentration (C i ), than leaves under the W and R LEDs. B LEDs resulted in greater abaxial epidermal layer thickness and palisade cell length and width than the R and W LED treatments. The palisade cells also developed a more cylindrical shape in response to the B LEDs. B LED leaves also showed greater guard cell length, breadth, and area, and stomatal density, than W or R LEDs, which may contribute to increased A, g s and E at higher PPFDs.

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Increased Antioxidant Activity and Changes in Phenolic Profile of Kalanchoe pinnata (Lamarck) Persoon (Crassulaceae) Specimens Grown Under Supplemental Blue Light

Cited by 72 publications

References 61 publications

Gastroprotective activity of the hydroethanolic extract and ethyl acetate fraction from Kalanchoe pinnata (Lam.) Pers.

Gastroprotective activity of the hydroethanolic extract and ethyl acetate fraction from Kalanchoe pinnata (Lam.) Pers.

Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy

Response of Eustoma Leaf Phenotype and Photosynthetic Performance to LED Light Quality

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