Increased Anticoagulation During Cardiopulmonary Bypass by Prostaglandin E (1)

Kozek‐Langenecker, Sibylle A.; Wanzel, Oliver; Berger, Reinhard; Kettner, Stephan C.; Coraim, F.

doi:10.1213/00000539-199811000-00001

Cited by 13 publications

(2 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PGE1 inhibits thrombin formation and platelet procoagulant activity, and its addition to heparin enhances anticoagulation during bypass. 7 PGE1 use is not routine in our institution, but we have used this dual regimen previously in selected cases with severe coagulopathy. Prostaglandins may inhibit platelet activation via the P2Y1 ADP receptor.…”

Section: Discussionmentioning

confidence: 99%

Case Report of a Successful Pediatric Central Venovenous Extracorporeal Life Support via Right Atrium-Pulmonary Artery Cannulation for Severe Chest Trauma and Hemorrhagic Shock

Öztürk

Girgin

et al. 2022

ASAIO Journal

View full text Add to dashboard Cite

Hypoxemic arrests due to severe traumatic pulmonary injury may not respond to usual medical support. Extracorporeal life support (ECLS) can be life-saving; adequate flows are needed in this setting along with a careful choice of anticoagulation strategies to minimize bleeding. A 44 month old child, who presented with severe blunt chest trauma after being run over by a truck was resuscitated with active compressions and code medications seven times before arrival to the intensive care unit. Failure to adequately oxygenate led to an unconventional approach with cannulations of the right atrium (RA) and pulmonary artery (PA) via sternotomy. Anticoagulation regimen started after bleeding had slowed down with active transfusion of blood products and consisted of low-dose heparin and alprostadil infusions for the initial 48 hours. Heparin was adjusted per institutional guidelines thereafter. Physiologically veno-venous central approach enabled fast stabilization due to full oxygenation without recirculation. Additionally, the dual anticoagulation regimen was safe for circuit maintenance. The described method can be considered in small children with similar risks and conditions.

show abstract

Section: Discussionmentioning

confidence: 99%

Case Report of a Successful Pediatric Central Venovenous Extracorporeal Life Support via Right Atrium-Pulmonary Artery Cannulation for Severe Chest Trauma and Hemorrhagic Shock

Öztürk

Girgin

et al. 2022

ASAIO Journal

View full text Add to dashboard Cite

show abstract

“…PGE 1 is a potent antagonist of platelet activation and functions via the platelet prostaglandin receptor by up-regulating adenylate cyclase production of intracellular cyclic adenosine monophosphate. 18 PGE 1 also inhibits tissue factor/factor VIIa-dependent thrombin formation, 21 impairing thrombus formation. Second, PGE 1 induces dilatation of smooth muscle, 18 which results in mild hypotension.…”

mentioning

confidence: 99%

Prevention of thrombosis with prostaglandin E1 in a patient with catastrophic antiphospholipid syndrome

Ozaki

Ogata

Yokoyama

et al. 2005

Can J Anesth/J Can Anesth

View full text Add to dashboard Cite

P Pu ur rp po os se e: : Catastrophic antiphospholipid syndrome (CAPS) is a variant of antiphospholipid syndrome and presents with life-threatening symptoms of multiorgan failure due to thrombosis. We present a patient with CAPS secondary to an ovarian cancer. In such cases, it is believed that the thrombotic risk disappears after surgical removal of the cancer. The intraoperative management was challenging because of the risks of two opposing complications: catastrophic exacerbation of the thrombotic tendency triggered by the surgical stimulus and major bleeding due to the necessary anticoagulation. We describe the intraoperative management of hemostasis in a patient with CAPS.C Cl li in ni ic ca al l f fe ea at tu ur re es s: : A 44-yr-old female patient with CAPS underwent resection of an ovarian cancer, which was suspected to be associated with her coagulation abnormality. She had both arterial and venous thromboembolism, including cerebral infarction, embolic gangrene, and pulmonary emboli. Serological examinations revealed increased anticardiolipin IgG antibody and decreased protein C activity. Before surgery, an inferior vena cava filter was placed to prevent perioperative pulmonary embolism. Prostaglandin E 1 (PGE 1 ; 100 ng·kg -1 ·min -1 ) was given intraoperatively to suppress platelet aggregation and thrombin generation and to maintain arterial blood flow. No apparent coagulation abnormalities were observed during surgery, neither hypercoagulation nor a tendency to bleed. No additional thrombotic symptoms developed during a six-month follow-up.C Co on nc cl lu us si io on n: : The use of PGE 1 , an inhibitor of thrombin formation and platelet function, and placement of an inferior vena cava filter were associated with the uneventful surgical resection of an ovarian cancer in a patient with CAPS. Objectif

show abstract

Prostaglandin el attenuates impairment of cellular immunity after cardiopulmonary bypass

Sano

Masuda

Morita

et al. 2006

Jpn J Thorac Caridovasc Surg

View full text Add to dashboard Cite

show abstract

Increased Anticoagulation During Cardiopulmonary Bypass by Prostaglandin E (1)

Cited by 13 publications

References 23 publications

Case Report of a Successful Pediatric Central Venovenous Extracorporeal Life Support via Right Atrium-Pulmonary Artery Cannulation for Severe Chest Trauma and Hemorrhagic Shock

Case Report of a Successful Pediatric Central Venovenous Extracorporeal Life Support via Right Atrium-Pulmonary Artery Cannulation for Severe Chest Trauma and Hemorrhagic Shock

Prevention of thrombosis with prostaglandin E1 in a patient with catastrophic antiphospholipid syndrome

Prostaglandin el attenuates impairment of cellular immunity after cardiopulmonary bypass

Contact Info

Product

Resources

About