Increased anticipatory but decreased consummatory brain responses to food in sisters of anorexia nervosa patients

Horndasch, Stefanie; O'Keefe, Sophie; Lamond, Anneka; Brown, Katie; McCabe, Ciara

doi:10.1192/bjpo.bp.115.002550

Cited by 5 publications

(5 citation statements)

References 42 publications

(71 reference statements)

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“…It could be argued that AN patients are biased towards both emotional (disease-unrelated) and non-emotional (disease-related), a feature that persists following recovery [ 94 , 99 ]. Interestingly, increased activation of the amygdala during anticipation of food is reported also in siblings of AN patients, a finding that supports further the notion of amygdalar hypersensitivity as a premorbid biomarker [ 100 ]. Amygdala activation after gustatory stimulation may be the result of intense fear of weight gain [ 19 ].…”

Section: Discussionsupporting

confidence: 71%

“…Interestingly, increased activation of the amygdala during anticipation of food is reported also in siblings of AN patients, a finding that supports further the notion of amygdalar hypersensitivity as a premorbid biomarker. [100] Amygdala activation after gustatory stimulation may be the result of intense fear of weight gain [19]. It has been proposed that increased activity in the amygdala may lead to fearful emotional processing concerning body image issues, and in turn influences calorie intake and weight gain [97].…”

Section: Discussion Of Structural Imaging Studiesmentioning

confidence: 99%

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Neuroimaging Findings in Adolescents and Young Adults with Anorexia Nervosa: A Systematic Review

et al. 2021

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Background: Anorexia nervosa (AN) is a serious, multifactorial mental disorder affecting predominantly young females. This systematic review examines neuroimaging findings in adolescents and young adults up to 24 years old, in order to explore alterations associated with disease pathophysiology. Methods: Eligible studies on structural and functional brain neuroimaging were sought systematically in PubMed, CENTRAL and EMBASE databases up to October 05, 2020. Results: Thirty-three studies were included, investigating a total of 587 patients with a current diagnosis of AN and 663 healthy controls (HC). Global and regional grey matter (GM) volume reduction as well as white matter (WM) microstructure alterations were detected. The mainly affected regions were the prefrontal, parietal and temporal cortex, hippocampus, amygdala, insula, thalamus and cerebellum as well as various WM tracts such as corona radiata and superior longitudinal fasciculus (SLF). Regarding functional imaging, alterations were pointed out in large-scale brain networks, such as default mode network (DMN), executive control network (ECN) and salience network (SN). Most findings appear to reverse after weight restoration. Specific limitations of neuroimaging studies in still developing individuals are also discussed. Conclusions: Structural and functional alterations are present in the early course of the disease, most of them being partially or totally reversible. Nonetheless, neuroimaging findings have been open to many biological interpretations. Thus, more studies are needed to clarify their clinical significance.

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Section: Discussionsupporting

confidence: 71%

Section: Discussion Of Structural Imaging Studiesmentioning

confidence: 99%

Neuroimaging Findings in Adolescents and Young Adults with Anorexia Nervosa: A Systematic Review

et al. 2021

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“…Our finding of increased activation in the right putamen across anticipation paradigms, including positive and negative affective cues, supports previous suggestions of the existence of a universal anticipatory system, comprising striatal regions, that becomes activated in response to both rewarding and aversive stimuli (Cowdrey et al., 2011 ; Horndasch et al., 2016 ). The putamen may be part of a core circuit for long‐term memory‐based stable reward value discrimination (Kunimatsu et al., 2019 ).…”

Section: Discussionsupporting

confidence: 91%

“…These findings support the existence of a universal anticipatory system, shared in reaction to reward and aversive cues. Accordingly, the exploration of both rewarding and aversive food cues in relation to EDs, has suggested that increased neural anticipatory responses, in striatal regions during anticipation of both rewarding and aversive food, and in the thalamus and amygdala during anticipation of aversive food only, might be biomarkers for AN (Cowdrey et al., 2011 ; Horndasch et al., 2016 ). However, critical questions remain as to whether these findings are robust and generalisable to other ED subtypes.…”

Section: Introductionmentioning

confidence: 99%

Altered anticipatory brain responses in eating disorders: A neuroimaging meta‐analysis

Desrivières

2023

Euro Eating Disorders Rev

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Objective: Functional neuroimaging studies have found differential neural activation patterns during anticipation-related paradigms in participants with eating disorders (EDs) compared to controls. However, publications reported conflicting results on the directionality and location of the abnormal activations. There is an urgent need to integrate our existing knowledge of anticipation, both rewarding and aversive, to elucidate these differences. Method:We conducted an activation likelihood estimation (ALE) metaanalysis to quantitatively review functional neuroimaging studies that evaluated differences between brain correlates of anticipation in participants with and without disordered eating. PubMed, Web of Sciences, PsycINFO, Medline and EMBASE were searched for studies published up to November 2022.Exploratory sub-analyses to check for differences between reward and nonreward anticipation among all anticipation paradigms.Results: Twenty-one references met the inclusion criteria for meta-analysis.The meta-analysis across anticipation all tasks identified a significant hyperactivation cluster in the right putamen in participants with disordered eating (n = 17 experiments) and a significant hypoactivation cluster in the left inferior parietal lobule (n = 13 experiments), in participants with disordered eating compared to controls.Conclusions: These findings and sub-analyses of reward-and non-rewardrelated cues suggest potential pathophysiological mechanisms underlying anticipatory responses to rewarding and aversive cues in ED.

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“…Horndasch et al [46] used an incentive delay task, allowing the measurement of both anticipation and receipt of pleasant and aversive tastes. In a group of first-degree relatives of patients with AN, the authors observed increased neural reward processing during the anticipation of both pleasant and unpleasant tastes, but they observed a decreased reward processing during the receipt of aversive taste.…”

Section: Neural Processing Of Food-related Stimulimentioning

confidence: 99%

Neural Processing of Disorder-Related Stimuli in Patients with Anorexia Nervosa: A Narrative Review of Brain Imaging Studies

Simon

Stopyra

Friederich

2019

JCM

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Abnormalities and alterations in brain function are commonly associated with the etiology and maintenance of anorexia nervosa (AN). Different symptom categories of AN have been correlated with distinct neurobiological patterns in previous studies. The aim of this literature review is to provide a narrative overview of the investigations into neural correlates of disorder-specific stimuli in patients with AN. Although findings vary across studies, a summary of neuroimaging results according to stimulus category allows us to account for methodological differences in experimental paradigms. Based on the available evidence, the following conclusions can be made: (a) the neural processing of visual food cues is characterized by increased top-down control, which enables restrictive eating, (b) increased emotional and reward processing during gustatory stimulation triggers disorder-specific thought patterns, (c) hunger ceases to motivate food foraging but instead reinforces disorder-related behaviors, (d) body image processing is related to increased emotional and hedonic reactions, (e) emotional stimuli provoke increased saliency associated with decreased top-down control and (f) neural hypersensitivity during interoceptive processing reinforces avoidance behavior. Taken together, studies that investigated symptom-specific neural processing have contributed to a better understanding of the underlying mechanisms of AN.

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Increased anticipatory but decreased consummatory brain responses to food in sisters of anorexia nervosa patients

Cited by 5 publications

References 42 publications

Neuroimaging Findings in Adolescents and Young Adults with Anorexia Nervosa: A Systematic Review

Neuroimaging Findings in Adolescents and Young Adults with Anorexia Nervosa: A Systematic Review

Altered anticipatory brain responses in eating disorders: A neuroimaging meta‐analysis

Neural Processing of Disorder-Related Stimuli in Patients with Anorexia Nervosa: A Narrative Review of Brain Imaging Studies

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