Increased Anti-Müllerian Hormone Serum Concentrations in Prepubertal Daughters of Women with Polycystic Ovary Syndrome

Sir-Petermann, Teresa; Codner, Ethel; Maliqueo, Manuel; Echiburú, Bárbara; Hitschfeld, Catalina; Crisosto, Nicolás; Pérez-Bravo, Francisco; Recabarren, Sergio E; Cassorla, Fernando

doi:10.1210/jc.2005-2693

Cited by 129 publications

(88 citation statements)

References 46 publications

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“…Some years ago, serum AMH was reported to be barely detectable or extremely low in prepubertal women (Hudson et al 1990, Lee & Donahoe 1993, but these investigators used an ELISA with limited sensitivity (0.5 ng/ml). The sensitivity of newer ELISAs has improved (0.006 ng/ml) and a more recent study has reported appreciable levels of AMH in the serum of infants and young girls (Sir-Petermann et al 2006). However, these same investigators measured higher levels in peripubertal girls (Crisosto et al 2007), which suggest that serum AMH is relatively low in females before puberty.…”

Section: Discussionmentioning

confidence: 99%

Photoperiod-dependent modulation of anti-Müllerian hormone in female Siberian hamsters, Phodopus sungorus

Kabithe

Place²

2008

Reproduction

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Fertility and fecundity decline with advancing age in female mammals, but reproductive aging was decelerated in Siberian hamsters (Phodopus sungorus) raised in a short-day (SD) photoperiod. Litter success was significantly improved in older hamsters when reared in SD and the number of primordial follicles was twice that of females held in long days (LD). Because anti-Mü llerian hormone (AMH) appears to inhibit the recruitment of primordial follicles in mice, we sought to determine whether the expression patterns of AMH differ in the ovaries and serum of hamsters raised in SD versus LD. Ovaries of SD female hamsters are characterized by a paucity of follicular development beyond the secondary stage and are endowed with an abundance of large eosinophilic cells, which may derive from granulosa cells of oocyte-depleted follicles. In ovaries from 10-week-old SD hamsters, we found that the so-called 'hypertrophied granulosa cells' were immunoreactive for AMH, as were granulosa cells within healthy-appearing primary and secondary follicles. Conversely, ovaries from age-matched LD animals lack the highly eosinophilic cells present in SD ovaries. Therefore, AMH staining in LD was limited to primary and secondary follicles that are comparable in number to those found in SD ovaries. The substantially greater AMH expression in SD ovaries probably reflects the abundance of hypertrophied granulosa cells in SD ovaries and their relative absence in LD ovaries. The modulation of ovarian AMH by day length is a strong mechanistic candidate for the preservation of primordial follicles in female hamsters raised in a SD photoperiod. Reproduction (2008) 135 335-342

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Section: Discussionmentioning

confidence: 99%

Photoperiod-dependent modulation of anti-Müllerian hormone in female Siberian hamsters, Phodopus sungorus

Kabithe

Place²

2008

Reproduction

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“…67 Furthermore, increased AMH concentrations have been found in girls aged 4-7 years born of mothers with PCOS. 68 Evidence that hereditary factors contribute to the pathogenesis of the syndrome is also found in animal studies showing that prenatal exposure to increased androgen levels can lead to offspring with PCOS features. 69,70 Although these data support a genetic contribution to the pathogenensis of the syndrome, an environmental component cannot be excluded given the fact that prenatal exposure to high androgen levels as well as other unknown factors are operative.…”

Section: Amh In Polycystic Ovary Syndromementioning

confidence: 93%

The clinical significance of anti-Müllerian hormone evaluation in gynecological endocrinology

Karkanaki¹,

Vosnakis²,

Panidis³

2011

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Anti-Müllerian hormone (AMH) is a homodimeric glycoprotein, a member of the transforming growth factor-β superfamily. Over the last decade, a large number of studies examining the multiple roles of AMH have been published. AMH levels accurately reflect the ovarian follicular reserve and could, therefore, be considered as an extremely sensitive marker of ovarian aging and a valuable tool in the diagnosis and the recognition of recurrence of granulosa cell tumors. Furthermore, AMH evaluation is of clinical importance in predicting the success of in vitro fertilization (IVF). Additionally, AMH could be a surrogate diagnostic marker of polycystic ovary syndrome in cases in which ultrasonographic examination is not possible. This article is a review of the clinical usefulness of AMH evaluation in the fields of gynecological endocrinology, menopause, gynecological oncology and assisted reproduction. Special reference is made to the possible implications of AMH in the pathogenesis of polycystic ovary syndrome and the relationship between AMH and obesity.

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“…The study conducted on infants (months 2-3) who were born to PCOS mothers have showed that serum concentrations of AMH were 20.40 ± 15.60 pmol/L. In a prepubertal group who had PCOS mothers, the levels were 14.80 ± 7.70 pmol/L whereas in prepubertal girls who had mothers in the control group the levels were 9.61 ± 4.40 pmol/L [42]. The levels of FSH, LH, testosterone and E2 were investigated in the same study and FSH levels were found lower in the study group than in the control group.…”

Section: Discussionmentioning

confidence: 99%

Anti-Müllerian Hormone (AMH) in Adults with Polycystic Ovary Syndrome and Pregnants

Sarıyıldız¹

2016

Eu Clin Anal Med

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ÖzetAmaç: Çalışmada puberta öncesi ve sonrası sağlıklı kız çocukları; over kistli yetişkinler ile hamilelerde anti-Müllerian hormonu AMH ve bazı biyokimyasal parametrelerin karşılaştırılmaları yoluyla değişimin saptanması amaç-landı. Gereç ve Yöntem: Bu çalışma Dr. Faruk Sükan Doğum ve Çocuk Hastanesinin polikliniklerine başvuran ve herhangi bir metabolik hastalığı olmayan dört grupta yer alan toplam100 katılımcı üzerinde gerçekleştirildi. Çalış-maya 7-12 yaş arası prepubertal dönemdeki kız çocuklarından (n=25), 18-24 yaş arası over kist sendromlu (n=25), 18-25 yaş arası hamileliğin 1.trimesterindeki kadınlardan (n=25) ve 18-24 yaş arası (n=25) sağlıklı bireyler kontrol grubu olarak alındı. Bulgular: Prepubertal dönemde (7-12 yaş arası) 25 kız çocuğu ile kontrol grubu(18-24 yaş arası) 25 kız çocuğu AMH değerle-ri sırasıyla 3,62 pg/dl; 3,60 pg/dl olarak bulundu (p═0,7636). Çalışmada over kist sendromlu grubun (18-24 yaş arası) AMH seviyesi 4,11 pg/dL (p═0,8690) olarak bulundu. Tartışma: AMH'nin klinik çalışmalarda over rezervinin tespit edilmesinde kullanılması infertilite tedavisinin ve yardımcı üreme tekniklerinin başarısını önceden tahmin etme ve PKOS'un teşhisi anlamında avantajlar sağlamaktadır. Anahtar KelimelerAnti-Müllerian Hormon; Over Kisti; Hamilelik; Fertilite AbstractAim: The aim of the study was to investigate serum anti-Müllerian hormone (AMH) and various biochemical parameter levels in healthy females before and after puberta, adults with polycystic ovary syndrome and pregnant women. Material and Method: The present study was performed on 100 female volunteers in four groups who applied to the polyclinic in Dr. Faruk Sukan maternal and children hospital and who had no metabolic syndrome.The groups were classified as: group 1: 7-12 years of age, prepubertal period (n=25); group 2: 18-25 years of age, pregnant females in the first trimester (n=25); group 3: 18-24 years of age, suffering from ovarian cysts (n=25); group 4: 18-24 years of age postpubertal as a control group (n=25). Results: The levels of AMH were found in prepubertal females (age 7-12) and the control group (age 18-24) as 3.62 pg/dl and 3.60 pg/dl, respectively (p=0.7636). The levels of AMH were 4.11 pg/dl (p=0.8690) in the women suffering from polycystic ovary syndrome. Discussion: The use of AMH in the measurement of ovarian reserve in clinical trials provides an advantage in early diagnosis of infertility and polycystic ovary syndrome (PCOS).

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Increased Anti-Müllerian Hormone Serum Concentrations in Prepubertal Daughters of Women with Polycystic Ovary Syndrome

Abstract: We conclude that serum AMH concentrations are increased in prepubertal daughters of PCOS women, suggesting that these girls appear to show evidence of an altered follicular development during infancy and childhood.

Cited by 129 publications

References 46 publications

Photoperiod-dependent modulation of anti-Müllerian hormone in female Siberian hamsters, Phodopus sungorus

Photoperiod-dependent modulation of anti-Müllerian hormone in female Siberian hamsters, Phodopus sungorus

The clinical significance of anti-Müllerian hormone evaluation in gynecological endocrinology

Anti-Müllerian Hormone (AMH) in Adults with Polycystic Ovary Syndrome and Pregnants

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