Increased Angiogenesis and Decreased Programmed Cell Death Increases the Risk of Uterine Cervical Cancer

Qin, Zhenli; Zheng, Xueli; Xu, Yihuan

doi:10.1055/s-0034-1390459

Cited by 1 publication

(1 citation statement)

References 13 publications

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“… 4 Recently, it has been documented that accumulation of mutant p53 protein results in an increased cell proliferation rate and reduced apoptosis. 21 RBBP6 has been shown to also contribute towards p53 accumulation, and consequently, this could lead to abrogation of apoptosis and cell growth. In this study, we showed that RBBP6 is highly expressed in tumour-associated stroma, which was directly related to apoptosis levels and indirectly associated with Bcl-2 expression.…”

Section: Discussionmentioning

confidence: 99%

RBBP6 Is Abundantly Expressed in Human Cervical Carcinoma and May Be Implicated in Its Malignant Progression

Dlamini

Ledwaba²,

Hull

et al. 2019

Biomark�Cancer

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RBBP6 is a novel gene encoding splicing-associated proteins. There are 3 protein isoforms (isoforms 1-3). RBBP6 isoforms 1 has been shown to interact with both p53 and Rb. It also plays a role in the induction of apoptosis and the regulation of the cell cycle. The expression of RBBP6 has been documented in several cancers but RBBP6 expression in cervical cancer has not been well studied. The aim of this study was to establish expression levels and tissue distribution of the RBBP6 gene products at both protein and messenger RNA (mRNA) levels in cervical cancer by immunocytochemistry and in situ hybridization (ISH). A link between RBBP6 expression, apoptosis, and cervical cancer progression was also investigated. RBBP6 mRNA was expressed in the nuclei and cytoplasm of normal and tumour cervical epithelium. In general, expression was high in the cytoplasm and nuclei of moderately differentiated and invasive carcinoma. Immunolabelling results were confirmed by image analysis and ISH experiments. Apoptosis assays using TUNEL correlated with the expression of the RBBP6 gene in all examined cases. This is the first report on the abundant expression of RBBP6 in cervical cancer and its involvement in the malignant progression of cervical cancer. Because of the high expression and corresponding pro-apoptotic activity observed in cervical cancer cells in this study, we suggest that RBBP6 is involved in the malignant progression of cervical cancer. RBBP6 proteins can therefore be targeted for therapeutic interventions against cervical cancer.

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Section: Discussionmentioning

confidence: 99%

RBBP6 Is Abundantly Expressed in Human Cervical Carcinoma and May Be Implicated in Its Malignant Progression

Dlamini

Ledwaba²,

Hull

et al. 2019

Biomark�Cancer

View full text Add to dashboard Cite

show abstract

Increased Angiogenesis and Decreased Programmed Cell Death Increases the Risk of Uterine Cervical Cancer

Abstract: Therefore, our data suggest that development of new anticancer or antiviral drugs could efficiently compromise the HPV-16 mediated angiogenesis and reduced apoptosis in cervical cancer and thus will improve the survival rate of patients.

Cited by 1 publication

References 13 publications

RBBP6 Is Abundantly Expressed in Human Cervical Carcinoma and May Be Implicated in Its Malignant Progression

RBBP6 Is Abundantly Expressed in Human Cervical Carcinoma and May Be Implicated in Its Malignant Progression

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