Increased amygdala and parahippocampal gyrus activation in schizophrenic patients with auditory hallucinations: An fMRI study using independent component analysis

Escartí, María J.; Iglesia-Vayá, María de la; Martí‐Bonmatí, Luis; Robles, Montserrat; Carbonell, José; Lull, Juan José; García-Martí, Gracián; Manjón, José V.; Aguilar, Eduardo J.; Alemán, André; Sanjuán, Julio

doi:10.1016/j.schres.2009.12.028

Cited by 70 publications

(55 citation statements)

References 48 publications

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“…A 1.5 Tesla scanner (Philips Medical Systems) was used to acquire BOLD contrasts during a stimulation paradigm (Escartí et al, 2010; Sanjuán et al, 2005). An emotional auditory paradigm was designed to evoke emotions related to the patients' hallucinatory experiences (Supplementary material 1).…”

Section: Methodsmentioning

confidence: 99%

“…The ICA analysis was performed using the Group ICA approach fMRI Toolbox (GIFT, http://www.icatb.sourceforge.net). Components of interest (CoI) were selected (in terms of the individual beta values related to the emotional task), and the regressors in each component were entered into a one-sample t -test with a threshold of p < 0.01 (Escartí et al, 2010). Age was controlled for in a second analysis.…”

Section: Methodsmentioning

confidence: 99%

“…These results implicated circuits subserving the processing of emotional stimuli as a neural substrate of AH. In a subsequent work, we studied functional connectivity in response to an emotional auditory paradigm in patients with AH by conducting independent component analyses (ICA) (Escartí et al, 2010). Using this approach, the activated areas could be obtained by selecting the ICA components related to the emotional auditory paradigm.…”

Section: Introductionmentioning

confidence: 99%

“…Using this approach, the activated areas could be obtained by selecting the ICA components related to the emotional auditory paradigm. Functional connectivity is then characterized by detecting statistical dependencies among the time courses of the areas activated in response to the auditory emotional stimuli (Escartí et al, 2010). In addition to the temporal, frontal and parietal networks detected in all subjects, in the schizophrenia patients with AH, we observed a specific pattern of functional connectivity involving activation of the limbic structures (predominantly the amygdala and parahippocampal gyrus).…”

Section: Introductionmentioning

confidence: 99%

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Abnormal synchrony and effective connectivity in patients with schizophrenia and auditory hallucinations

Vayá

Escartí

Molina‐Mateo

et al. 2014

NeuroImage: Clinical

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Auditory hallucinations (AH) are the most frequent positive symptoms in patients with schizophrenia. Hallucinations have been related to emotional processing disturbances, altered functional connectivity and effective connectivity deficits. Previously, we observed that, compared to healthy controls, the limbic network responses of patients with auditory hallucinations differed when the subjects were listening to emotionally charged words. We aimed to compare the synchrony patterns and effective connectivity of task-related networks between schizophrenia patients with and without AH and healthy controls.Schizophrenia patients with AH (n = 27) and without AH (n = 14) were compared with healthy participants (n = 31). We examined functional connectivity by analyzing correlations and cross-correlations among previously detected independent component analysis time courses. Granger causality was used to infer the information flow direction in the brain regions.The results demonstrate that the patterns of cortico-cortical functional synchrony differentiated the patients with AH from the patients without AH and from the healthy participants. Additionally, Granger-causal relationships between the networks clearly differentiated the groups. In the patients with AH, the principal causal source was an occipital–cerebellar component, versus a temporal component in the patients without AH and the healthy controls.These data indicate that an anomalous process of neural connectivity exists when patients with AH process emotional auditory stimuli. Additionally, a central role is suggested for the cerebellum in processing emotional stimuli in patients with persistent AH.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Abnormal synchrony and effective connectivity in patients with schizophrenia and auditory hallucinations

Vayá

Escartí

Molina‐Mateo

et al. 2014

NeuroImage: Clinical

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“…Therefore, reduced amygdala activity may impair effective use of emotional and cognitive resources to resolve conflict. On the other hand, it should be noted that other previous reports have shown amygdala hyperactivity during emotional processing or resting state in patients with schizophrenia (Escartí et al., 2010; Pinkham et al., 2015). This discrepancy may be attributed to a difference in cognitive loading involved in emotional tasks.…”

Section: Discussionmentioning

confidence: 99%

Involvement of amygdala–prefrontal dysfunction in the influence of negative emotion on the resolution of cognitive conflict in patients with schizophrenia

et al. 2018

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IntroductionPatients with schizophrenia often have impaired cognition and abnormal conflict control. Conflict control is influenced by the emotional values of stimuli. This study investigated the neural basis of negative emotion interference with conflict control in schizophrenia.MethodsSeventeen patients with schizophrenia and 20 healthy controls underwent functional magnetic resonance imaging while performing the emotional Simon task, in which positive or negative emotional pictures were located in congruent or incongruent positions. Analysis was focused on identifying brain regions with the significant interaction among group, emotion, and conflict in whole brain voxel‐wise analysis, and abnormality in their functional connectivity in the patient group.ResultsThe regions showing the targeted interaction was the right amygdala, which exhibited significantly reduced activity in the negative congruent (t = −2.168, p = 0.036) and negative incongruent (t = −3.273, p = 0.002) conditions in patients versus controls. The right amygdala also showed significantly lower connectivity with the right dorsolateral prefrontal cortex in the cognitive and emotional loading contrast (negative incongruent—positive congruent) in patients versus controls (t = −5.154, p < 0.01), but not in the cognitive‐only or emotional‐only loading contrast.ConclusionsThese results suggest that negative emotion interferes with cognitive conflict resolution in patients with schizophrenia due to amygdala–dorsolateral prefrontal cortex disconnection. Based on these findings, interventions targeting conflict control under negative emotional influence may promote cognitive rehabilitation in patients with schizophrenia.

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Parahippocampal area three gray matter is reduced in first‐episode schizophrenia spectrum: Discovery and replication samples

Curtis

Coffman

Salisbury

2020

Human Brain Mapping

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Early course schizophrenia is associated with reduced gray matter. The specific structures affected first and how deficits impact symptoms and cognition remain unresolved. We used the Human Connectome Project multimodal parcellation (HCP‐MMP) to precisely identify cortical areas and investigate thickness abnormalities in discovery and replication samples of first‐episode schizophrenia spectrum individuals (FESz). In the discovery sample, T1w scans were acquired from 31 FESz and 31 matched healthy controls (HC). Thickness was calculated for 360 regions in Freesurfer. In the replication sample, high‐resolution T1w, T2w, and BOLD‐rest scans were acquired from 23 FESz and 32 HC and processed with HCP protocols. Thickness was calculated for regions significant in the discovery sample. After FDR correction (q < .05), left and right parahippocampal area 3 (PHA3) were significantly thinner in FESz. In the replication sample, bilateral PHA3 were again thinner in FESz (q < .05). Exploratory correlation analyses revealed left PHA3 was positively associated with hallucinations and right PHA3 was positively associated with processing speed, working memory, and verbal learning. The novel use of the HCP‐MMP in two independent FESz samples revealed thinner bilateral PHA3, suggesting this byway between cortical and limbic processing is a critical site of pathology near the emergence of psychosis.

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Increased amygdala and parahippocampal gyrus activation in schizophrenic patients with auditory hallucinations: An fMRI study using independent component analysis

Cited by 70 publications

References 48 publications

Abnormal synchrony and effective connectivity in patients with schizophrenia and auditory hallucinations

Abnormal synchrony and effective connectivity in patients with schizophrenia and auditory hallucinations

Involvement of amygdala–prefrontal dysfunction in the influence of negative emotion on the resolution of cognitive conflict in patients with schizophrenia

Parahippocampal area three gray matter is reduced in first‐episode schizophrenia spectrum: Discovery and replication samples

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