Increased Adherence to the Mediterranean Diet after Lifestyle Intervention Improves Oxidative and Inflammatory Status in Patients with Non-Alcoholic Fatty Liver Disease

Monserrat-Mesquida, Margalida; Quetglas-Llabrés, Maria Magdalena; Bouzas, Cristina; Montemayor, Sofía; Mascaró, Catalina M.; Casares, Miguel; Llompart, Isabel; Ugarriza, Lucía; Martínez, J. Alfredo; Tur, Josep A.; Sureda, Antoni

doi:10.3390/antiox11081440

Cited by 11 publications

(11 citation statements)

References 74 publications

(73 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…High MPO levels are associated with an increment of oxidative stress and inflammation which are characteristic of overweight and obesity [ 39 ]. Our results are in accordance with others studies showing that a better AMD and an increase in physical activity ameliorate the inflammatory profile and, therefore, decrease the levels of MPO [ 40 , 41 ]. Omentin is an anti-inflammatory adipokine mainly expressed and secreted from visceral adipose tissue [ 42 ].…”

Section: Discussionsupporting

confidence: 93%

Mediterranean Diet Improves Plasma Biomarkers Related to Oxidative Stress and Inflammatory Process in Patients with Non-Alcoholic Fatty Liver Disease

et al. 2023

Self Cite

View full text Add to dashboard Cite

Non-alcoholic fatty liver disease (NAFLD) shows liver fat depots without alcohol consumption. NAFLD does not have specific drug therapies, with a healthy lifestyle and weight loss being the main approaches to prevent and treat NAFLD. The aim was to assess the antioxidant and pro-inflammatory state in patients with NAFLD after 12-month-lifestyle intervention depending on the change in adherence to a Mediterranean diet (AMD). Antioxidant and inflammatory biomarkers were measured in 67 adults (aged 40–60 years old) diagnosed with NAFLD. Anthropometric parameters and dietary intake were measured by a validated semi-quantitative 143-item food frequency questionnaire. The nutritional intervention improved anthropometric and biochemical parameters after a 12-month follow-up. However, decreases in alanine aminotransferase (ALT) and C reactive protein (CRP) were higher in participants with high AMD, which also showed higher improvement in physical fitness (Chester step test) and intrahepatic fat contents. The intervention reduced plasma levels of malondialdehyde, myeloperoxidase, zonulin, and omentin, and increased resolvin D1 (RvD1), whereas the decrease in leptin, ectodysplasin-A (EDA), cytokeratin-18 (CK-18), interleukin-1ra (IL-1ra) and endotoxin was only significant in participants with higher AMD. The current study showed that a one-year nutritional intervention improved main NAFLD features such as body mass index, IFC, liver enzymes, and prooxidant and proinflammatory status. There was also a decrease in the concentration of plasmatic endotoxin, suggesting an improvement in intestinal permeability. These health benefits were more evident in participants that improved AMD to a greater extent. The trial was registered at ClinicalTrials.gov with registry number NCT04442620.

show abstract

Section: Discussionsupporting

confidence: 93%

Mediterranean Diet Improves Plasma Biomarkers Related to Oxidative Stress and Inflammatory Process in Patients with Non-Alcoholic Fatty Liver Disease

et al. 2023

Self Cite

View full text Add to dashboard Cite

show abstract

“…In all of these, we found a significant improvement in both the mean values obtained at the baseline visit and at 12 months, as well as in the prevalence of high risk before and after the diet. This is of vital importance, since there are currently no drugs approved for the treatment of NAFLD, as dietary intervention and physical exercise have been shown to be effective in the treatment of NAFLD [ 72 , 73 , 74 , 75 ]. It is worth highlighting the values achieved in the very significant decrease in the high risk of liver fibrosis, obtained in both men and women: BAAT high of −32.4% for the former and −26.6% for the latter.…”

Section: Discussionmentioning

confidence: 99%

Dietary Intervention on Overweight and Obesity after Confinement by COVID-19

et al. 2023

View full text Add to dashboard Cite

Background: Obesity has become a public health problem in our society and is associated with many diseases, including type 2 diabetes mellitus, cardiovascular diseases, dyslipidemia, respiratory diseases, and cancer. Several studies relate weight loss in obese patients to improved anthropometric measurements and cardiometabolic risk. The objective of our study was to evaluate anthropometric changes, analytical parameters, insulin resistance, fatty liver, and metabolic scales, after a personalized weight loss program, through dietary advice to increase adherence to the Mediterranean diet and a motivational booster via mobile SMS messaging. Methods: Intervention study on a sample of 1964 workers, in which different anthropometric parameters were evaluated before and after dietary intervention: the metabolic score of insulin resistance; non-alcoholic fatty liver disease using different scales; metabolic syndrome; atherogenic dyslipidemia; and the cardiometabolic index. A descriptive analysis of the categorical variables was performed, by calculating the frequency and distribution of the responses for each one. For quantitative variables, the mean and standard deviation were calculated, since they followed a normal distribution. Bivariate association analysis was performed by applying the chi-squared test (corrected by Fisher’s exact statistic when conditions required it) and Student’s t-test for independent samples (for comparison of means). Results: The population subjected to the Mediterranean diet improved in all the variables evaluated at 12 months of follow-up and compliance with the diet. Conclusions: Dietary advice on a Mediterranean diet and its reinforcement with reminder messages through the use of mobile phones may be useful to improve the parameters evaluated in this study and reduce the cardiometabolic risk of patients.

show abstract

“…These results are in accordance with a previous study evidencing high levels of enzymatic activity of catalase and SOD in plasma from patients with high cardiovascular risk after an intervention with the MedDiet [ 65 ]. Moreover, it was observed that after 6 months of lifestyle intervention, IL-6 and TNFα were decreased, although only significantly for IL-6 in the group with high adherence to the MedDiet [ 14 ]. Some of the beneficial effects of the MedDiet are related to the presence of bioactive compounds with antioxidant and anti-inflammatory activity [ 66 , 67 ].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, high adherence to the MedDiet is related to better values of intrahepatic fat content (IFC) in NAFLD patients and a better status of MetS characteristics, such as high decreases in body weight, body mass index (BMI), and blood pressure [ 13 ]. A high adherence to the MedDiet is associated with high improvements in the proinflammatory and pro-oxidative status and the cardiorespiratory fitness of NAFLD patients [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Plasma Fatty Acid Composition, Oxidative and Inflammatory Status, and Adherence to the Mediterranean Diet of Patients with Non-Alcoholic Fatty Liver Disease

Monserrat-Mesquida,

Quetglas-Llabrés,

Bouzas

et al. 2023

Antioxidants

Self Cite

View full text Add to dashboard Cite

Non-alcoholic fatty liver disease (NAFLD) is a complex and increasingly prevalent cardiometabolic disorder worldwide. As of today, NAFLD is a pathology without specific pharmacological treatment, with the Mediterranean diet (MedDiet) being the most widely used approach for its management. The objective of this study is to assess the effects of adherence to the Mediterranean diet on fatty acid plasma levels, as well as on the oxidative and inflammatory status of NAFLD patients. A total of 100 adult patients (40–60 years old) diagnosed with NAFLD and from the Balearic Islands, Spain, were classified into three groups according to their adherence to the MedDiet. Consumption was assessed using a validated 143-item semiquantitative Food Frequency Questionnaire. Food items (g/day) were categorised according to their processing using the NOVA system. Anthropometrics, blood pressure, aminotransferases, Dietary Inflammatory Index (DII), inflammatory biomarkers, and fatty acid levels were measured in the plasma of NAFLD patients. High adherence to the MedDiet is associated to a highly plant-based diet, low ultra-processed food (UPF) consumption, low intake of dietary lipids, low intake of animal fats, high intake of monounsaturated fatty acid (MUFA; mainly palmitoleic acid), low intake of saturated fatty acids (SFAs; practically all dietary SFAs), low intake of trans-fatty acids, high intake of omega-3 fatty acids (mainly eicosapentaenoic acid), a higher n-6:n-3 in ratio, low intake of omega-6 fatty acids, and a low level of interleukin-6 (IL-6). High adherence to the MedDiet is related to a better fatty acid profile in the plasma, fewer SFAs and more MUFA and polyunsaturated fatty acids (PUFAs), a plasma biochemical profile, better proinflammatory status, and decreased ultra-processed food consumption of NAFLD patients.

show abstract

Increased Adherence to the Mediterranean Diet after Lifestyle Intervention Improves Oxidative and Inflammatory Status in Patients with Non-Alcoholic Fatty Liver Disease

Cited by 11 publications

References 74 publications

Mediterranean Diet Improves Plasma Biomarkers Related to Oxidative Stress and Inflammatory Process in Patients with Non-Alcoholic Fatty Liver Disease

Mediterranean Diet Improves Plasma Biomarkers Related to Oxidative Stress and Inflammatory Process in Patients with Non-Alcoholic Fatty Liver Disease

Dietary Intervention on Overweight and Obesity after Confinement by COVID-19

Plasma Fatty Acid Composition, Oxidative and Inflammatory Status, and Adherence to the Mediterranean Diet of Patients with Non-Alcoholic Fatty Liver Disease

Contact Info

Product

Resources

About