Increased acylation-stimulating protein, C-reactive protein, and lipid levels in young women with polycystic ovary syndrome

Wu, Yue; Zhang, Jianhua; Wen, Yu; Wang, Hongwei; Zhang, Muxun; Cianflone, Katherine

doi:10.1016/j.fertnstert.2007.11.031

Cited by 52 publications

(49 citation statements)

References 53 publications

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“…The association with CRP levels had been previously reported in patients affected by type 2 diabetes [24], whereas the relationship with triglyceride is a further confirmation of previous studies [25].…”

Section: Disclosure Statementsupporting

confidence: 88%

Relationship between C3 Levels and Common Carotid Intima-Media Thickness in Overweight and Obese Patients

Pergola¹,

Ciccone²,

Guida³

et al. 2011

Obes Facts

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Objective: The study aim was to compare C3 levels with the common carotid artery intima-media thickness (CCAIMT) in subjects of both genders, with a wide range of BMI, independently of age, gender, and abdominal obesity. Method: 140 euthyroid, mainly overweight/obese subjects (age 18–30 years) were examined. BMI, waist circumference, blood pressure, fasting insulin, glucose, lipids, C3 and C-reactive protein serum concentrations, and insulin resistance degree (estimated by homeostasis model assessment for insulin resistance (HOMAIR)) were measured. Results: CCA-IMT was positively (p < 0.001) correlated with BMI, waist circumference, systolic and diastolic blood pressures, HOMAIR, and insulin, CRP, and C3 serum levels. The multiple linear regression analysis showed that only male gender and waist circumference maintained an independent relation with the CCA-IMT. Conclusion: This study suggests that central fat accumulation and male gender independently increase the thickness of the arterial wall, whereas inflammation and inflammatory markers do not have an independent effect on this parameter.

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Section: Disclosure Statementsupporting

confidence: 88%

Relationship between C3 Levels and Common Carotid Intima-Media Thickness in Overweight and Obese Patients

Pergola¹,

Ciccone²,

Guida³

et al. 2011

Obes Facts

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“…Showing progesterone as the only significant predictor of the ASP levels in non-obese women may suggest that this hormone may have a significant role in enhancing ASP production in females. This, however, does not exclude the possibility that high levels of ASP may also reflect ASP resistance as in hyperlipidemia during pregnancy or reproductive disorders (26,43). No evident correlation was seen between the ASP levels and the lipid profile of these healthy women, most probably because they are in the fasting state where lipid levels are normally low.…”

Section: Discussionmentioning

confidence: 83%

Acylation-stimulating protein increases and correlates with increased progesterone levels during the luteal phase of the menstrual cycle

Saleh¹,

Al-Khanbashi²,

Al-Maarof³

et al. 2009

European Journal of Endocrinology

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Objective: The menstrual cycle represents a continuous state of change in terms of female sex steroid environment. Progesterone is linked to increased fat storage while estrogen exerts anti-lipogenic effects. This study investigated variations in the potent lipogenic factor acylation-stimulating protein (ASP), and examined its association with hormonal and lipid profile alterations across the menstrual cycle. Methods and design: Nineteen non-obese women with regular menstrual cycles were investigated in a longitudinal study during the follicular, ovulatory, and mid-luteal phases (ML) of the cycle. Fasting ASP, LH, FSH, progesterone, estradiol, insulin, lipid profile, and apoproteins were evaluated during different phases of the cycle. Results: ASP levels changed significantly throughout the menstrual cycle (K-related Friedman test: PZ0.013). Interestingly, these changes coincide with variations in progesterone levels across the cycle as no significant change in the ASP levels was seen across the follicular phases of the cycle, followed by a significant increase in the ovulatory phase, which continued to elevate toward the ML. The ASP levels correlated positively with the progesterone levels normally elevated in the ML. No significant correlation was seen between ASP and estrogen or any other measured female hormone. Multiple regression analysis including all measured parameters and body mass index showed that progesterone was the only significant predictor of the ASP levels. Conclusion: Our findings suggest that during the menstrual cycle of normal women, the ASP levels coincidentally fluctuate with the progesterone levels, possibly reflecting cooperation between them in fat storage enhancement.

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“…Chronically increased circulating plasma ASP is associated with obesity, metabolic syndrome, insulin resistance, type 2 diabetes, cardiovascular disease, and polycystic ovary disease (8). Whereas ASP correlates with adiposity, increased ASP is noted in metabolic disturbances even without obesity (53,57).…”

Section: Discussionmentioning

confidence: 99%

Acute injection of ASP in the third ventricle inhibits food intake and locomotor activity in rats

Roy

Gauvreau

et al. 2011

American Journal of Physiology-Endocrinology and Metabolism

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ing protein (ASP; also known as C3adesArg) stimulates triglyceride synthesis and glucose transport via interaction with its receptor C5L2, which is expressed peripherally (adipose tissue, muscle) and centrally. Previous studies have shown that ASP-deficient mice (C3KO) and C5L2-deficient mice (C5L2KO) are hyperphagic (59 to 229% increase, P Ͻ 0.0001), which is counterbalanced by increased energy expenditure measured as oxygen consumption (V O2) and a lower RQ. The aim of the present study was to evaluate ASP's effect on food intake, energy expenditure, and neuropeptide expression. Male rats were surgically implanted with intracerebroventricular (icv) cannulas directed toward the third ventricle. After a 5-h fast, rats were injected, and food intake was assessed at 0.5, 1, 2, 4, 16, 24, and 48 h, with a 5-to 7-day washout period between each injection. Acute icv injections of ASP (0.3-1,065 pmol) had a time-dependent effect on decreasing food intake by 20 to 57% (P Ͻ 0.05). Decreases were detected by 30 min (maximum 57%, P Ͻ 0.01) and at the highest dose effects extended to 48 h (19%, P Ͻ 0.05, 24-to 48-h period). Daily body weight gain was decreased by 131% over the first 24 h and 29% over the second 24 h (P Ͻ 0.05). A conditioned taste aversion test indicated that there was no malaise. Furthermore, acute ASP injection affected energy substrate usage, demonstrated by decreased V O2 and RQ (P Ͻ 0.05; implicating greater fatty acid usage), with a 49% decrease in total activity over 24 h (P Ͻ 0.05). ASP administration also increased anorexic neuropeptide POMC expression (44%) in the arcuate nucleus, with no change in NPY. Altogether ASP may have central in addition to peripheral effects. acylation-stimulating protein; C5L2; energy metabolism; proopiomelanocortin IN RECENT YEARS, MUCH ATTENTION HAS FOCUSED on the hypothalamic-adipose axis (46). White adipose tissue (WAT), recognized originally for its capacity to store excess dietary energy in the form of triglycerides (TG), is now considered an endocrine organ because of its capacity to secrete hormones and cytokines (17). WAT is now recognized as a fundamental participant in the control of energy metabolism (22). The number of adipokines has expanded rapidly, and these include leptin, adiponectin, resistin, acylation-stimulating protein (ASP), and many more (17). The role of ASP and its involvement in the control of energy balance and in the development of obesity have been actively studied in our group for the last decade.ASP promotes TG synthesis in WAT through interaction with its cell surface receptor C5L2. Activation and phosphorylation of C5L2 leads to increased fatty acid uptake, increased glucose transport, and stimulation of diacylglycerol acyltransferase activity (9,10,19,20). ASP is produced through cleavage of the precursor protein complement C3 via factor B and adipsin (factor D) interaction generating C3a, which is rapidly desarginated to produce ASP (also known as C3adesArg) (6, 25). C3-knockout mice (C3 Ϫ/Ϫ ; also known as C3KO) are deficient in AS...

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Increased acylation-stimulating protein, C-reactive protein, and lipid levels in young women with polycystic ovary syndrome

Cited by 52 publications

References 53 publications

Relationship between C3 Levels and Common Carotid Intima-Media Thickness in Overweight and Obese Patients

Relationship between C3 Levels and Common Carotid Intima-Media Thickness in Overweight and Obese Patients

Acylation-stimulating protein increases and correlates with increased progesterone levels during the luteal phase of the menstrual cycle

Acute injection of ASP in the third ventricle inhibits food intake and locomotor activity in rats

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