Increased Activity on Radiocolloid Scintigraphy in Splenic Hamartoma

Okada, J; Yoshikawa, Ken; Uno, Kimiichi; Arimizu, N; Gotou, Hiromi; Ogata, S; Kashiwagi, Yoshikazu; Hasegawa, Y; Tamaru, JUNICHl; Mikata, A

doi:10.1097/00003072-199002000-00012

Cited by 18 publications

(13 citation statements)

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“…Many cases were documented as case reports or in small series. To date, in excess of 130 splenic hamartomas have been documented in the English literature 1 –63 . Overall, hamartomas were detected over a wide age range (11 months to 86 years) and with a mean age of 47 years at presentation.…”

Section: Discussionmentioning

confidence: 99%

Splenic Vascular Lesions: Unusual Features and a Review of the Literature

Lam¹,

Yip²,

Peh

1999

Aust. N.Z. J. Surg.

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Hamartoma and peliosis are uncommon splenic lesions. Approximately 120 splenic hamartomas and 40 splenic peliosis have been reported in the English literature. In the present study, a unique case of multiple splenic hamartomas with peliosis was reported. The splenic lesions were incidental findings in a 36-year-old man with ruptured sarcomatoid renal cell carcinoma. They were diagnosed clinically as metastatic renal cell carcinoma. On pathological examination, peliosis was noted in the splenic hamartomas as well as in the splenic parenchyma. In addition, the clinicopathological features of five other splenic hamartomas (including one giant hamartoma) noted in our department were presented. A re-evaluation of the features of the splenic hamartomas documented in the English literature was also done.

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Section: Discussionmentioning

confidence: 99%

Splenic Vascular Lesions: Unusual Features and a Review of the Literature

Lam¹,

Yip²,

Peh

1999

Aust. N.Z. J. Surg.

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“…Radiocolloid scintigraphy, such as Tc-99m phytate, is also used in the diagnosis of splenic hamartoma [13,14]. Certain types of hamartoma show an accumulation on radiocolloid imaging, whereas other types of lesions such as metastases and malignant lymphoma show no accumulation.…”

Section: Discussionmentioning

confidence: 99%

“…Certain types of hamartoma show an accumulation on radiocolloid imaging, whereas other types of lesions such as metastases and malignant lymphoma show no accumulation. It is speculated that the uptake of radiocolloids reflects the function of proliferating reticuloendothelial cells in the tumor [13]. Accumulation of radiocolloids in splenic tumors is considered to be an indication of reticuloendothelial system function and the lesion can therefore be diagnosed as either pulposal or mixed type.…”

Section: Discussionmentioning

confidence: 99%

Splenic hamartoma: a case report and clinicopathological analysis of Japanese cases

Maeda¹,

Okabayashi²,

Dabanaka³

et al. 2011

Clin J Gastroenterol

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A 75-year-old man was referred to our department for the treatment of a gastric submucosal tumor-like protrusion which had gradually enlarged over 3 years. After examination with various types of imaging modalities, a splenic mass was diagnosed. Splenectomy was performed because it was difficult to determine preoperatively whether the splenic mass was benign or malignant. The postoperative pathological examination revealed a splenic hamartoma without malignancy. Despite the preoperative examination with advanced diagnostic imaging techniques and equipment, an accurate diagnosis of splenic hamartoma is difficult due to its rarity, lack of specific symptoms, and various inadequacies of radiological imaging techniques. Here we present a rare case of splenic hamartoma and discuss the clinical characteristics obtained from a review of Japanese cases of this rare condition.

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“…As discussed further in the pathologic differential diagnosis, this combination of imaging techniques may also aid in the radiological differential diagnosis between splenic hamartomas and hemangiomas [8]. Additional details on imaging of these lesions are given in references [4] and [9].…”

Section: Discussionmentioning

confidence: 99%

“Hamartoma” of the Spleen (Splenoma) in Children

et al. 2004

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Hamartomas of the spleen or splenomas, are uncommon benign tumorous growths in this organ which have not been well characterized in children. We report four patients, 4 to 11 years old, who had splenomegaly and splenic "hamartomas" associated with different hematologic conditions (refractory microcytic anemia, sickle cell anemia, hereditary spherocytosis, and dyserythropoietic hemolytic anemia). All patients had total splenectomy as a primary therapeutic approach or to lessen their transfusion requirements. In only one patient was a focal splenic mass identified preoperatively with contrasted computed tomography (CT) scans and magnetic resonance imaging (MRI). None of the patients showed a mass by ultrasonography. Gross examination showed enlarged spleens (315-724 g) which on cut surface revealed a single nodule in one and multiple bulging nodules in three specimens. The nodules varied from 1.3 to 7 cm and were indistinct from the surrounding nonlymphoid splenic (i.e., red pulp) parenchyma. Histology of the nodules showed red splenic pulp with variable histiocytic proliferation, focal extramedullary hematopoiesis, lympho-plasmacytosis, fibrosis, and siderotic-calcific deposits. Intranodular small T- and B-cell lymphoid aggregates but no organized secondary follicles or periarteriolar sheaths were seen. Proliferation antigen Ki-67 (Mib-1) immunostains showed a low (< 5%) proliferation index in the nodules and surrounding tissue. Reticulin stains did not show a capsule or border between the normal spleen and the nodules. The critical histologic differential diagnosis for these lesions is with benign vascular tumors. These can be identified by their more disorderly pattern, by immunohistochemistry and by their higher proliferation index. It is our contention that these splenic nodules are not true hamartomas, as they seem to result from remote ischemic or infectious/inflammatory insults, leading to the fibro-inflammatory reaction and deposition of calcium and hemosiderin that is better designated with the descriptive term of splenoma. Review of the literature and our own experience indicates that most children with splenic hamartomas or splenomas as we prefer to call them, have an underlying hematologic disorder likely made worse by a state of hypersplenism that explains the consistent improvement in the blood values after splenectomy.

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Increased Activity on Radiocolloid Scintigraphy in Splenic Hamartoma

Cited by 18 publications

References 0 publications

Splenic Vascular Lesions: Unusual Features and a Review of the Literature

Splenic Vascular Lesions: Unusual Features and a Review of the Literature

Splenic hamartoma: a case report and clinicopathological analysis of Japanese cases

“Hamartoma” of the Spleen (Splenoma) in Children

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