1956
DOI: 10.3181/00379727-93-22733
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Increased Activity of Renal Glutaminases in Guinea Pig Following Prolonged Administration of Acid or Alkali.

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1957
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Cited by 17 publications
(3 citation statements)
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“…If a single mechanism is involved, this finding destroys the concept that ammonia secretion is merely an obli gatory consequence of the acidification of urine with protons trapping the diffusible NH 3 which remains in equilibrium with the low steady state con centration of NHs in tubular cells. The possibility that an entirely separate device is operative in the alkalotic guinea pig has not been excluded but seems unlikely in view of this group ' s finding (46) that the glutaminase I (phosphate-activated) and glutaminase II (pyruvate-activated) activity of guinea pig kidney homogenates increase 100 and 40 per cent respectively in acidosis, and 250 and 70 per cent in alkalosis. These were paralleled by 60 and 90 per cent increases in glutamine synthetase activity in these two states, respectively.…”
Section: Kamin and Handlermentioning
confidence: 91%
“…If a single mechanism is involved, this finding destroys the concept that ammonia secretion is merely an obli gatory consequence of the acidification of urine with protons trapping the diffusible NH 3 which remains in equilibrium with the low steady state con centration of NHs in tubular cells. The possibility that an entirely separate device is operative in the alkalotic guinea pig has not been excluded but seems unlikely in view of this group ' s finding (46) that the glutaminase I (phosphate-activated) and glutaminase II (pyruvate-activated) activity of guinea pig kidney homogenates increase 100 and 40 per cent respectively in acidosis, and 250 and 70 per cent in alkalosis. These were paralleled by 60 and 90 per cent increases in glutamine synthetase activity in these two states, respectively.…”
Section: Kamin and Handlermentioning
confidence: 91%
“…This was confirmed in rats when Davies and Yudkin (11) and others (7,12) found that the administration of HCl increased and the administration of NaHCO3 decreased the activity of rat kidney glutaminase. The observation of similar changes in acidotic guinea pigs and rabbits (13) has suggested that ammonia excretion in all mammals, including man, is regulated in part by adaptive changes in the activity of renal glutaminase.…”
mentioning
confidence: 91%
“…In the rat [23,24] and in the guinea pig [5] a relationship has been demonstrated between ammonia excreted in the urine during NH4C1 induced acidosis and glutaminase activity in kidney tissue. In the dog, by contrast, glutaminase activity does not increase during or after 7 days loading with NH4C1 while ammonia excretion becomes greater [18,23], Thus, it is premature to draw any general conclusions at present as to the adaptive role of glutaminase in ammonia production by the kindey [13].…”
mentioning
confidence: 99%