Increased activin A levels in prediabetes and association with carotid intima-media thickness: a cross-sectional analysis from I-Lan Longitudinal Aging Study

Kuo, Cheng–Deng; Lu, Ya Wen; Hsu, Chien Yi; Chang, Chun Chin; Chou, Ruey‐Hsing; Liu, Li Kuo; Chen, Liang Kung; Huang, Po Hsun; Chen, Jaw Wen; Lin, Shing Jong

doi:10.1038/s41598-018-27795-2

Cited by 13 publications

(14 citation statements)

References 41 publications

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“…Recently, the first report was provided showing that systemic activin A level is elevated in humans with CKD, already at stage 2 [43]. Furthermore, systemic activin A levels are associated with aging and metabolic disorders where elevated activin A is an independent risk factor for prediabetes and diabetes [36]. In obese subjects, serum activin A levels correlate with parameters of the metabolic syndrome and left ventricular diastolic dysfunction [82].…”

Section: Discussionmentioning

confidence: 99%

Circadian rhythm of activin A and related parameters of mineral metabolism in normal and uremic rats

Nordholm

Egstrand

Gravesen

et al. 2019

Pflugers Arch - Eur J Physiol

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Activin A is a new fascinating player in chronic kidney disease-mineral and bone disorder (CKD-MBD), which is implicated in progressive renal disease, vascular calcification, and osteodystrophy. Plasma activin A rises early in the progression of renal disease. Disruption of circadian rhythms is related to increased risk of several diseases and circadian rhythms are observed in mineral homeostasis, bone parameters, and plasma levels of phosphate and PTH. Therefore, we examined the circadian rhythm of activin A and CKD-MBD-related parameters (phosphate, PTH, FGF23, and klotho) in healthy controls and CKD rats (5/6 nephrectomy) on high-, standard- and low-dietary phosphate contents as well as during fasting conditions. Plasma activin A exhibited circadian rhythmicity in healthy control rats with fourfold higher values at acrophase compared with nadir. The rhythm was obliterated in CKD. Activin A was higher in CKD rats compared with controls when measured at daytime but not significantly when measured at evening/nighttime, stressing the importance of time-specific reference intervals when interpreting plasma values. Plasma phosphate, PTH, and FGF23 all showed circadian rhythms in control rats, which were abolished or disrupted in CKD. Plasma klotho did not show circadian rhythm. Thus, the present investigation shows, for the first time, circadian rhythm of plasma activin A. The rhythmicity is severely disturbed by CKD and is associated with disturbed rhythms of phosphate and phosphate-regulating hormones PTH and FGF23, indicating that disturbed circadian rhythmicity is an important feature of CKD-MBD. Electronic supplementary material The online version of this article (10.1007/s00424-019-02291-2) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Circadian rhythm of activin A and related parameters of mineral metabolism in normal and uremic rats

Nordholm

Egstrand

Gravesen

et al. 2019

Pflugers Arch - Eur J Physiol

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“…Wu et al conducted a research focusing on activin A levels in diabetes mellitus patients and revealed that the mean activin A levels in normal, impaired glucose tolerance, and diabetes patient groups were 90.1 ± 24.8 pg/mL, 89.6 ± 20.3 pg/mL, and 98.4 ± 31.6 pg/mL, respectively [ 10 ]. Elsewhere, Kuo et al reported activin A levels in normal, prediabetes, and diabetes patient groups of 491.2 ± 165.3 pg/mL, 559.0 ± 178.5 pg/mL, and 572.7 ± 167.0 pg/mL, respectively [ 19 ]. Finally, research on activin A in patients with CKD undergoing hemodialysis was also carried out by Burowski et al [ 11 ] and reported predialysis activin A levels of 122 ± 55.9 pg/mL.…”

Section: Discussionmentioning

confidence: 99%

“…Kuo et al examined the levels of activin A in normal, prediabetes, and diabetes patients [ 19 ], reporting findings of 491.2 ± 165.3 pg/mL, 559.0 ± 178.5 pg/mL, and 572.7 ± 167.0 pg/mL, respectively. Furthermore, patients with prediabetes and diabetes had increased levels of activin as compared with that in the normal glycemic group.…”

Section: Discussionmentioning

confidence: 99%

“…There are still not many studies covering the relationship between the activin A level and human cIMT, although Kuo et al reported a relationship between the activin A level and cIMT in humans in a population of prediabetes and diabetes patients [ 19 ]. The results obtained through Spearman regression logistic analysis of the total population ( N = 457) suggested a positive correlation between the activin A level and cIMT ( r = 0.263; p < 0.001).…”

Section: Discussionmentioning

confidence: 99%

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The Association between the Activin A Serum Level and Carotid Intima-Media Thickness in Chronic Kidney Disease Patients

Yonata

Ali

Indrajaya

et al. 2020

International Journal of Nephrology

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Introduction. Chronic kidney disease (CKD) is associated with high mortality rates, mainly as a result of cardiovascular complications. Meanwhile, recent studies have suggested a role of a homodimer protein called activin A in chronic kidney disease-mineral and bone disorder (CKD-MBD) conditions that may exist in the vascular calcification and osteolytic process. Ultrasound examination of the carotid intima-media thickness (cIMT) is a noninvasive method to assess vascular calcification. This study aimed to analyze the relationship between the activin A serum level and cIMT in patients with CKD at Mohammad Hoesin Hospital, Palembang, Indonesia. Methods. We conducted a hospital-based, cross-sectional study of consecutive CKD patients at the Department of Internal Medicine, Mohammad Hoesin Hospital, from July to November 2019. The level of activin A was measured by enzyme-linked immunosorbent assay. Meanwhile, cIMT measurements were collected by B-mode ultrasound imaging. Results. A total of 55 patients with CKD were included in this investigation. The median serum activin A level in these patients was 236.17 (116.33–283) pg/mL, while the median cIMT was 0.8 (0.6–1.45) mm. A relationship between the serum activin A level and cIMT (r = 0.449; p = 0.001 ) was observed. During multivariate analysis with linear regression, triglyceride p = 0.049 , phosphate p = 0.005 , and activin A p = 0.020 serum levels were factors associated with cIMT. Conclusion. In this study, a relationship between the activin A serum level and cIMT in patients with CKD was identified. Vascular calcification should be screened for in all CKD patients by the measurement of cIMT.

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“…Furthermore, there is also evidence that activin A is associated with the severity of coronary atherosclerotic burden and is independently associated with CV events and mortality in patients with type 2 diabetes mellitus (55,56). In addition, even in patients with pre-diabetes, a positive association has been demonstrated between circulating levels of activin A and carotid intima-media thickness, a well-established marker of atherosclerosis (57).…”

Section: Activin Amentioning

confidence: 99%

Anti-inflammatory therapy for cardiovascular disease

Kosmas¹,

Silverio²,

Sourlas³

et al. 2019

Ann. Transl. Med

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Chronic subclinical inflammation is a central process in the pathogenesis of cardiovascular disease (CVD) and it has been linked with both the initiation and progression of atherosclerosis. Several pro-inflammatory cytokines, such as the C-reactive protein (CRP), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) have been described as independent risk factors for coronary heart disease and promoters of atherogenesis. Thus, extensive research is being conducted to assess the role of anti-inflammatory therapy in the primary and secondary prevention of CVD. Our review aims to provide the clinical and scientific data pertaining to the effects of different anti-inflammatory agents administered in patients with CVD.

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Increased activin A levels in prediabetes and association with carotid intima-media thickness: a cross-sectional analysis from I-Lan Longitudinal Aging Study

Cited by 13 publications

References 41 publications

Circadian rhythm of activin A and related parameters of mineral metabolism in normal and uremic rats

Circadian rhythm of activin A and related parameters of mineral metabolism in normal and uremic rats

The Association between the Activin A Serum Level and Carotid Intima-Media Thickness in Chronic Kidney Disease Patients

Anti-inflammatory therapy for cardiovascular disease

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