Increased 68Ga-FAPI Activity in Chondrosarcoma of Nasal Cavity

Xiao, Yang; Ou, Lei; Xü, Dong; Chen, Yue; Liu, Huipan

doi:10.1097/rlu.0000000000004023

Cited by 3 publications

(4 citation statements)

References 14 publications

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“…In one case report, 68 Ga-FAPI-46 helped in the diagnosis of malignant melanoma of the nasal cavity [265]. In another case report, 68 Ga-FAPI-46 was used in the diagnosis of chondrosarcoma of the nasal cavity [266].…”

Section: Role Of Pet/ct In the Management Of Sinonasal Malignancies U...mentioning

confidence: 99%

PET/CT Imaging in Treatment Planning and Surveillance of Sinonasal Neoplasms

Akay,

Pollard,

Saad Eddin

et al. 2023

Cancers

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Sinonasal cancers are uncommon malignancies with a generally unfavorable prognosis, often presenting at an advanced stage. Their high rate of recurrence supports close imaging surveillance and the utilization of functional imaging techniques. Whole-body 18F-FDG PET/CT has very high sensitivity for the diagnosis of sinonasal malignancies and can also be used as a “metabolic biopsy” in the characterization of some of the more common subgroups of these tumors, though due to overlap in uptake, histological confirmation is still needed. For certain tumor types, radiotracers, such as 11C-choline, and radiolabeled somatostatin analogs, including 68Ga-DOTATATE/DOTATOC, have proven useful in treatment planning and surveillance. Although serial scans for posttreatment surveillance allow the detection of subclinical lesions, the optimal schedule and efficacy in terms of survival are yet to be determined. Pitfalls of 18F-FDG, such as post-surgical and post-radiotherapy crusting and inflammation, may cause false-positive hypermetabolism in the absence of relapse.

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Section: Role Of Pet/ct In the Management Of Sinonasal Malignancies U...mentioning

confidence: 99%

PET/CT Imaging in Treatment Planning and Surveillance of Sinonasal Neoplasms

Akay,

Pollard,

Saad Eddin

et al. 2023

Cancers

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“…It has high tumor uptake and low background uptake in the detection of most type of cancers. [7][8][9] The case of Wu et al demonstrated that 68 Ga-FAPI outperformed 18 F-FDG in imaging myeloid sarcoma. 10 However, our case showed that there was no obvious difference between 68 Ga-DOTA-FAPI-04 and 18 F-FDG in the evaluation of myeloid sarcoma.…”

mentioning

confidence: 99%

“…Previous studies have reported the use of 18 F-FDG PET/CT in staging and response assessment in myeloid sarcoma.5,6 68 Ga-DOTA-FAPI-04 is a novel tumor tracer based on fibroblast-activation protein. It has high tumor uptake and low background uptake in the detection of most type of cancers [7][8][9]. The case of Wu et al demonstrated that…”

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confidence: 99%

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18F-FDG PET/CT and 68Ga-DOTA-FAPI-04 PET/CT Findings of Myeloid Sarcoma

et al. 2022

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A 28-year-old woman presented with a 2-month history of swelling and pain in the chest wall. An irregular soft tissue mass in the chest wall and mediastinum was showed on chest CT. 18F-FDG PET/CT revealed obvious FDG uptake in the mass. Subsequently, the patient was participated in a 68Ga-DOTA-FAPI-04 PET/CT tumor clinical trial. 68Ga-DOTA-FAPI-04 PET/CT also showed elevated tracer uptake in the mass. Biopsy of the mass confirmed a diagnosis of myeloid sarcoma.

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