Increased [18F]Fluorodeoxyglucose Accumulation in Right Ventricular Free Wall in Patients With Pulmonary Hypertension and the Effect of Epoprostenol

Oikawa, Minako; Kagaya, Yutaka; Otani, Hiroki; Sakuma, Masashi; Demachi, Jun; Suzuki, Jun; Takahashi, Tohru; Nawata, Jun; Ido, Tatsuo; Watanabe, Jun; Shirato, Kunio

doi:10.1016/j.jacc.2005.02.065

Cited by 242 publications

(203 citation statements)

References 23 publications

(23 reference statements)

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“…This is in line with what is observed in clinical cases of PAH (Oikawa et al, 2005;Lundgrin et al, 2012; unpublished data from our group).…”

Section: Cardiac Changes In Metabolismsupporting

confidence: 93%

“…Recent human and animal studies show evidence that there is a glycolytic shift in PAH and that these alterations are associated with an activation of glycolytic genes such as GLUT1, PDH and PDK (Oikawa et al, 2005;Fang et al 2012;Archer et al 2013) Our findings support this premise as demonstrated by elevated FDG SUVs in the RV and associated upregulation in glucose transporter GLUT4. There was a strong inverse correlation between increased FDG uptake and RV function suggesting that the glycolytic shift is maladaptive.…”

Section: Cardiac Changes In Metabolismsupporting

confidence: 83%

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The Effects of a Novel Endothelin Receptor Antagonist, Macitentan, on Right Ventricular Substrate Utilization and Function in a Sugen5416/Hypoxia Rat Model of Severe Pulmonary Artery Hypertension

Drozd¹,

Deng²,

Jiang³

et al. 2014

Canadian Journal of Cardiology

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“…This is in line with what is observed in clinical cases of PAH (Oikawa et al, 2005;Lundgrin et al, 2012; unpublished data from our group).…”

Section: Cardiac Changes In Metabolismsupporting

confidence: 93%

Section: Cardiac Changes In Metabolismsupporting

confidence: 83%

The Effects of a Novel Endothelin Receptor Antagonist, Macitentan, on Right Ventricular Substrate Utilization and Function in a Sugen5416/Hypoxia Rat Model of Severe Pulmonary Artery Hypertension

Drozd¹,

Deng²,

Jiang³

et al. 2014

Canadian Journal of Cardiology

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“…CTalso demonstrated marked dilation of the right ventricle in proportion to the left ventricle and bowing of the interventricular septum, a known secondary sign of elevated right heart pressure (31). An increase in right ventricular myocardial FDG uptake has been described in association with pulmonary arterial hypertension (32)(33)(34). Therefore, the finding of increased right ventricular wall uptake in this patient likely reflects acutely increased pulmonary arterial and right heart pressure because of the massive PE.…”

Section: Discussionmentioning

confidence: 64%

The Incidence of Pulmonary Embolism and Associated FDG-PET Findings in IV Contrast-Enhanced PET/CT

et al. 2014

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Rationale and Objectives: Most fluorine-18 fluorodeoxyglucose (FDG)-positron emission tomography with computed tomography (PET/ CT) studies are performed on cancer patients. These patients are at increased risk of pulmonary embolism (PE). In this retrospective review, we determined the rate of PE, and the prevalence of associated FDG-PET findings on intravenous (IV) contrast-enhanced PET/CT. Materials and Methods:We identified all PET/CT studies performed at our institution with a reported finding of PE between January 2005 and October 2012. The medical record was reviewed for symptoms, which were identified after the diagnosis of PE, and whether the patients received treatment. The prevalence of associated FDG-PET findings was determined.Results: A total of 65 total cases of PE (of 182,72 total PET/CT examinations) were identified of which 59 were previously unknown. This gives an incidental PE (IPE) rate of 0.32%. Of the patients where sufficient clinical information was available, 34 of 36 (94%) were treated either with therapeutic anticoagulation or inferior vena cava filter, and 30 of 36 (83%) were asymptomatic in retrospect. Of the patients with IPE, we found nine (15.2%) with associated focal pulmonary artery hypermetabolism, three (5.1%) with hypermetabolic pulmonary infarction, and one with increased isolated right ventricular FDG uptake (1.7%). One case of chronic PE demonstrated a focal hypometabolic filling defect in a pulmonary artery on PET. Conclusions:We found IPE in 0.32% of PET/CT scans. Focal pulmonary artery hypermetabolism or hypometabolism, and hypermetabolic pulmonary artery infarction with the ''rim sign'' were uncommonly associated with PE. These findings could raise the possibility of IPE in non-IV contrast-enhanced PET/CT studies.

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“…One study has demonstrated that PET RV 18 FDG uptake might be of clinical relevance after epoprostenol therapy. 80 Future studies are required to validate RV imaging parameters to assess therapeutic effects.…”

Section: Hybrid Imagingmentioning

confidence: 99%

State of the Art: Advanced Imaging of the Right Ventricle and Pulmonary Circulation in Humans (2013 Grover Conference Series)

et al. 2014

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Pulmonary arterial hypertension (PAH) is a progressive disease characterized by remodeling and vasoconstriction of the pulmonary vasculature, ultimately leading to right ventricular (RV) failure and death. Recent developments in echocardiography, cardiovascular magnetic resonance imaging, computed tomography, and positron emission tomography allow advanced, noninvasive, in vivo assessment of the RV and have contributed to the identification of risk factors, prognostic factors, and monitoring of therapeutic responses in patients with PAH. Although far from reaching its future potential, these techniques have not only provided global RV assessment but also allowed evaluation of changes in cellular and molecular tissue processes, such as metabolism, oxygen balance and ischemia, angiogenesis, and apoptosis. Integrated application of these techniques could provide full insights into the different pathophysiological aspects of a failing RV in the setting of PAH. Recent advances in hybrid imaging have implemented simultaneous measurements of myocardial and vascular interactions and will be one of the most important potential future developments.

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Increased [18F]Fluorodeoxyglucose Accumulation in Right Ventricular Free Wall in Patients With Pulmonary Hypertension and the Effect of Epoprostenol

Cited by 242 publications

References 23 publications

The Effects of a Novel Endothelin Receptor Antagonist, Macitentan, on Right Ventricular Substrate Utilization and Function in a Sugen5416/Hypoxia Rat Model of Severe Pulmonary Artery Hypertension

The Effects of a Novel Endothelin Receptor Antagonist, Macitentan, on Right Ventricular Substrate Utilization and Function in a Sugen5416/Hypoxia Rat Model of Severe Pulmonary Artery Hypertension

The Incidence of Pulmonary Embolism and Associated FDG-PET Findings in IV Contrast-Enhanced PET/CT

State of the Art: Advanced Imaging of the Right Ventricle and Pulmonary Circulation in Humans (2013 Grover Conference Series)

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