Increased 10-year cardiovascular disease and mortality risk scores in asymptomatic patients with calcium oxalate urolithiasis

Aydın, Hasan; Yencilek, Faruk; Erïhan, İsmet Bilger; Okan, Binnur; Sarıca, Kemal

doi:10.1007/s00240-011-0383-9

Cited by 17 publications

(18 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…33 The results suggested a higher predicted risk for both CVD (OR 8.36, 95% CI 3.81, 18.65) and mortality (OR 3.02, 95% CI 1.30, 7.02) for individuals with a history of kidney stones compared with controls.…”

Section: Discussionmentioning

confidence: 95%

History of Kidney Stones and the Risk of Coronary Heart Disease

Ferraro

Taylor

Eisner

et al. 2013

JAMA

183

134

View full text Add to dashboard Cite

Importance Kidney stone disease is common and may be associated with an increased risk of coronary heart disease (CHD). However, previous studies of the association between kidney stones and CHD have often not controlled for important risk factors, and the results have been inconsistent. Objective We examined the association between a history of kidney stones and the risk of CHD in three large prospective cohorts. Design, setting, and participants Prospective study of 45,748 men and 196,357 women in the United States without a history of CHD at baseline who were participants in the Health Professionals Follow-Up Study (HPFS, 51,529 men aged 40–75 years followed since 1986), Nurses’ Health Study (NHS) I (121,700 women aged 30–55 years followed since 1976) and II (116,430 women aged 25–42 years followed since 1989). The diagnoses of kidney stones and CHD were updated biennially during follow-up. Main outcome measure CHD was defined as fatal or non-fatal myocardial infarction (MI) or coronary revascularization. The outcome was identified by biennial questionnaires and confirmed through review of medical records (fatal and non-fatal MI). Results Out of a total of 242,105 participants, 19,678 reported a history of kidney stones. After up to 24 years of follow-up in men and 18 years in women, 16,838 incident cases of CHD occurred. After adjusting for potential confounders, among women, those with a reported history of kidney stones compared with those without had an increased risk of CHD in NHS I (incidence rate (IR) 754 vs 514/100,000 person-years; multivariate HR 1.18, 95% CI 1.08 to 1.28) and NHS II (IR 144 vs 55/100,000 person-years; multivariate HR 1.48, 95% CI 1.23 to 1.78); there was no significant association in men (IR 1,355 vs 1,022/100,000 person-years; multivariate HR 1.06, 95% CI 0.99 to 1.13). Similar results were found when analyzing the individual end-points (fatal and non-fatal MI, revascularization). Conclusions Among two cohorts of women, a history of kidney stones was associated with a modest but statistically significant increased risk of CHD; there was no significant association in a separate cohort of men. Further research is needed to determine whether the association is sex-specific.

show abstract

Section: Discussionmentioning

confidence: 95%

History of Kidney Stones and the Risk of Coronary Heart Disease

Ferraro

Taylor

Eisner

et al. 2013

JAMA

183

134

View full text Add to dashboard Cite

show abstract

“…The associations between cardiovascular disease and kidney stones have been well chronicled [21] . Aydin and colleagues [22] reported that cardiovascular disease and mortality were significantly higher in calcium oxalate kidney stone formers than non-stone formers. Those with calcium oxalate stones also had significantly higher total cholesterol, lower HDL, higher systolic blood pressure, and elevated highly sensitive C-reactive protein (hsCRP).…”

Section: Cardiovascular Disease and Urolithiasismentioning

confidence: 99%

The influence of metabolic syndrome and its components on the development of nephrolithiasis

Boyd

Wood

Whitaker

et al. 2018

Asian Journal of Urology

View full text Add to dashboard Cite

The prevalence of kidney stone disease is increasing, afflicting 7%–11% of the United States population. Multiple systemic conditions, including obesity and diabetes, are also on the rise. Further, the literature has demonstrated a strong association between metabolic syndrome, its components, and kidney stone disease. In this article, we aim to review the associations of metabolic syndrome and nephrolithiasis, discussing the pathophysiology, urinary parameters, and clinical presentations. With this knowledge, urologists will have a more comprehensive understanding of this complex population of metabolic stone formers enabling improved patient management and treatment of stone disease.

show abstract

“…Moreover, kidney stones are associated with a higher risk of CKD (5) and ESRD (1), two additional risk factors for CVD. Kidney stone formers have increased cardiovascular disease and mortality risk scores (6) as well as evidence of subclinical atherosclerosis (7). However, evidence linking kidney stones to CVD events is limited.…”

Section: Introductionmentioning

confidence: 99%

Kidney Stones and Cardiovascular Events

Alexander¹,

Hemmelgarn²,

Wiebe

et al. 2014

Clinical Journal of the American Society of Nephrology

122

View full text Add to dashboard Cite

Background and objectives Kidney stones are common in general clinical practice, and their prevalence is increasing. Kidney stone formers often have risk factors associated with atherosclerosis, but it is uncertain whether having a kidney stone is associated with higher risk of cardiovascular events. This study sought to assess the association between one or more kidney stones and the subsequent risk of cardiovascular events.Design, setting, participants, & measurements Cohort study of 3,195,452 people aged$18 years registered in the universal health care system in Alberta, Canada, between 1997 and 2009 (median follow-up of 11 years). People undergoing dialysis or with a kidney transplant at baseline were excluded. The primary outcome was the first acute myocardial infarction (AMI) during follow-up. We also considered other cardiovascular events, including death due to coronary heart disease, percutaneous transluminal coronary angioplasty (PTCA), coronary artery bypass grafting (CABG), and stroke.Results In total, 25,532 (0.8%) participants had at least one kidney stone, and 91,465 (3%) individuals had at least one cardiovascular event during follow-up. Compared with people without kidney stones and after adjustment for cardiovascular risk factors and other potential confounders, people who had at least one kidney stone had a higher risk of subsequent AMI (adjusted hazard ratio [HR], 1.40; 95% confidence interval [95% CI], 1.30 to 1.51), PTCA/CABG (HR, 1.63; 95% CI, 1.51 to 1.76), and stroke (HR, 1.26; 95% CI, 1.12 to 1.42). The magnitude of the excess risk associated with a kidney stone appeared more pronounced for younger people than for older people (P,0.001) and for women than men (P=0.01).Conclusions The occurrence of a kidney stone is associated with a higher risk of cardiovascular events, including AMI, PTCA/CABG, and stroke.

show abstract

Increased 10-year cardiovascular disease and mortality risk scores in asymptomatic patients with calcium oxalate urolithiasis

Cited by 17 publications

References 26 publications

History of Kidney Stones and the Risk of Coronary Heart Disease

History of Kidney Stones and the Risk of Coronary Heart Disease

The influence of metabolic syndrome and its components on the development of nephrolithiasis

Kidney Stones and Cardiovascular Events

Contact Info

Product

Resources

About