Increase with age of serum lipid peroxides: Implications for the prevention of atherosclerosis

Advanced oxidation protein products and malondialdehyde — the new biological markers of oxidative stress — are elevated in postmenopausal women

“…An age-related increase in the plasma concentration of MDA has been documented in several studies [28,33,35,36]. Miguel J et al, in their study on a group of healthy men and women ranging in age from 20 to 70 years, demonstrated an age-related increase in MDA levels only among the women [28]. In our study, no correlation between age and MDA levels was observed, possibly due to a narrow age range.…”

“…MDA is one of the most often used biomarkers of oxidative stress on lipids associated with aging. An age-related increase in the plasma concentration of MDA has been documented in several studies [28,33,35,36]. Miguel J et al, in their study on a group of healthy men and women ranging in age from 20 to 70 years, demonstrated an age-related increase in MDA levels only among the women [28].…”

“…Estrogens also have favorable effects on vascular oxidative stress by either increasing bioavailability of the vasoprotective molecule endothelium-derived nitric oxide or by modulating the expression and function of enzymes producing ROS, as well as antioxidant enzymes [27]. An increase in vascular oxidative stress in women after menopause has been reported in several studies [18][19][20]28]. Furthermore, hormone replacement therapy has been shown to improve oxidative stress status of postmenopausal women [18,[29][30][31][32].…”

Lipid peroxidation in neoplastic tissue of dogs with mammary cancer fed with different kinds of diet

“…It has been suggested that cholesterol is susceptible to oxidation, resulting in higher amounts of lipid peroxidation products during oxidative stress (7,27). Nevertheless, the blood concentration of TBARS has not been found to correlate with total cholesterol or triglycerides levels (18,28), which was also the case in our study. Furthermore, the blood concentration of vitamin E may be affected by lipid parameters (21).…”

Effects of menopause and tibolone on antioxidants in postmenopausal women

“…4,5 Oxidative stress can arise through the increased production of ROS and/or a de¢ciency of antioxidant defences. Antioxidant de¢ciencies can develop as a result of decreased antioxidant intake, decreased synthesis of enzymes with antioxidant activity, or increased antioxidant utilization.…”