Increase of the Seizure Threshold in C57Bl/6 Mice after Citicoline Administration

Карпова, М. Н.; Зиньковский, К А; Кузнецова, Л. В.; Klishina, N. V.

doi:10.1007/s10517-015-2750-y

Cited by 9 publications

(6 citation statements)

References 11 publications

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“…Karapova et al also investigated the inhibitory effects of citicoline on acute PTZ-induced generalized epileptiform activity using a mouse model. Their results showed that citicoline at higher doses has an anticonvulsive effect on acute generalized seizure activity [34]. In contrast, the study of Kim et al on the pilocarpine-induced seizure model, not only showed no protective effect of citicoline treatment, but also proved the adversely effects of citicoline on seizure [35].…”

Section: Discussionmentioning

confidence: 94%

Posible involvement of nitric oxide in anticonvulsant effects of citicoline on pentylenetetrazole and electroshock induced seizures in mice

Rasooli

Pirsalami

Moezi

2020

Heliyon

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Cerebroneurovascular trauma is recognized as an important risk factor in the development of seizure and epilepsy. Administration of citicoline in these situations is a conventional therapeutic strategy, which combines neurovascular protection and repair effects. The aim of the present study is clarifying the effect of acute and subchronic citicoline administration on pentylenetetrazole (PTZ) and electroshock induced seizures in mice. Besides we examined the probable role of NO and its interaction with citicoline in seizure experiments.Male mice were received acute and sub-chronic regimens of different doses of citicoline (62.5, 125, 250 and 500 mg/kg) before the intravenous or intraperitoneal PTZ-induced seizures or electroshock. To clarify the probable role of NO, 7-nitroindazole (7-NI) (60 mg/kg) or aminoguanidine (AG) (100 mg/kg) were injected 5 min before citicoline in separate groups.The results revealed that neither acute nor sub-chronic treatment with citicoline could affect the seizures induced by intravenous or intraperitoneal PTZ, but in electroshock model, citicoline showed anti-epileptic properties. Co-administration of citicoline and selective nitric oxide synthase (NOS) inhibitors amplified the anticonvulsant effect of citicoline.The current results indicated that citicoline has anticonvulsant effects probably through the inhibition of NO.

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Section: Discussionmentioning

confidence: 94%

Posible involvement of nitric oxide in anticonvulsant effects of citicoline on pentylenetetrazole and electroshock induced seizures in mice

Rasooli

Pirsalami

Moezi

2020

Heliyon

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“…Vidarabine exhibits potent antiviral activity and is widely used as an anti-herpesvirus agent ( 52 ). Citicoline exerts neuroprotective effects and has anticonvulsant properties ( 53 , 54 ). β-Nicotinamide mononucleotide possesses anti-aging properties ( 55 , 56 ).…”

Section: Resultsmentioning

confidence: 99%

UPLC-ESI-MS/MS-based widely targeted metabolomics reveals differences in metabolite composition among four Ganoderma species

Wei-Ye,

Hong-Bo,

Rui-Heng

et al. 2024

Front. Nutr.

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The Chinese name “Lingzhi” refers to Ganoderma genus, which are increasingly used in the food and medical industries. Ganoderma species are often used interchangeably since the differences in their composition are not known. To find compositional metabolite differences among Ganoderma species, we conducted a widely targeted metabolomics analysis of four commonly used edible and medicinal Ganoderma species based on ultra performance liquid chromatography-electrospray ionization-tandem mass spectrometry. Through pairwise comparisons, we identified 575–764 significant differential metabolites among the species, most of which exhibited large fold differences. We screened and analyzed the composition and functionality of the advantageous metabolites in each species. Ganoderma lingzhi advantageous metabolites were mostly related to amino acids and derivatives, as well as terpenes, G. sinense to terpenes, and G. leucocontextum and G. tsugae to nucleotides and derivatives, alkaloids, and lipids. Network pharmacological analysis showed that SRC, GAPDH, TNF, and AKT1 were the key targets of high-degree advantage metabolites among the four Ganoderma species. Analysis of Gene Ontology and Kyoto Encyclopedia of Genes and Genomes demonstrated that the advantage metabolites in the four Ganoderma species may regulate and participate in signaling pathways associated with diverse cancers, Alzheimer’s disease, and diabetes. Our findings contribute to more targeted development of Ganoderma products in the food and medical industries.

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“…One of the important effects of citicoline intake is the decreased glutamate release after accumulation after brain hypoxia, with a subsequent reduction of seizure activity of the brain that is aided by a decrease in the number of glutamatergic synapses and extracellular glutamate concentration [ 18 ]. This was evidenced by the studies done on experimental animals using intraperitoneal injection of citicoline leading to increased seizure threshold for both tonic and clonic seizures [ 19 ]. Moreover, a similar study showed that using citicoline with an antiepliptic drug (valropate) reduced the dose needed to control seizures in comparison to the use of the antiepileptic agent alone [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Citicoline in hypoxic ischemic encephalopathy in neonates: a randomized controlled trial

et al. 2023

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Background Hypoxic-ischemic encephalopathy (HIE) is one of the major complications that can lead to death or disability in neonates. We assessed the effect of citicoline as a neuroprotector in neonates with moderate and severe HIE. Methods This clinical trial was carried on 80 neonates with moderate to severe HIE who were not candidates for therapeutic cooling. They were subdivided randomly into two groups; citicoline treatment group which included 40 neonates who received citicoline 10 mg / kg /12 h IV for 4 weeks plus other supportive measures and the control group which included 40 neonates who were managed with placebo and the same supportive measures. All patients were evaluated for duration of mechanical ventilation (MV), need for inotropes, seizures (type, frequency, and duration), and duration of NICU. Cranial ultrasounds and brain magnetic resonance image (MRI) were performed for all included neonates after 4 weeks of treatment. Follow- ups of all neonates for the neurodevelopmental outcomes were done at 3, 6, 9, and 12 months. Results There was a significant reduction in the number of neonates having seizures after discharge in the citicoline-treated group (2 neonates) compared to the control group (11 neonates). Cranial ultrasound and MRI findings at 4 weeks were significantly better in the treatment group compared to the control group. Moreover, neurodevelopmental outcome showed significant improvement at 9 and 12 months in the citicoline treated neonates compared to the control group. There was statistically significant reduction in the duration of seizures, NICU stay, inotrope use, and MV in the treatment group compared to the control group. Citicoline was well tolerated with no remarkable side effects. Conclusion Citicoline could be a promising neuroprotector drug in neonates with HIE. Trial registration The study was registered at ClinicalTrials.gov (NCT03949049). Registered at 14 May 2019, https://clinicaltrials.gov/ct2/show/NCT03949049

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Increase of the Seizure Threshold in C57Bl/6 Mice after Citicoline Administration

Cited by 9 publications

References 11 publications

Posible involvement of nitric oxide in anticonvulsant effects of citicoline on pentylenetetrazole and electroshock induced seizures in mice

Posible involvement of nitric oxide in anticonvulsant effects of citicoline on pentylenetetrazole and electroshock induced seizures in mice

UPLC-ESI-MS/MS-based widely targeted metabolomics reveals differences in metabolite composition among four Ganoderma species

Citicoline in hypoxic ischemic encephalopathy in neonates: a randomized controlled trial

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