Increase of RT-Related Transmitted Drug Resistance in Non-CRF01_AE Among HIV Type 1–Infected Men Who Have Sex With Men in the 7 Cities of China

Zhao, Bin; Han, Xiaoxu; Xu, Junjie; Hu, Qinghai; Chu, Zhenxing; Zhang, Jing; Lü, Lin; Wang, Zhe; Fu, Jihua; Chen, Xi; Yan, Hongjing; Zhuang, Minghua; Lin, Wei; Sun, Amy; Zhang, Christiana Meng; Shang, Hong

doi:10.1097/qai.0000000000000467

Cited by 22 publications

(24 citation statements)

References 23 publications

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“…It is interesting that we also detected the V179D mutation in our sample, indicating that this mutation may persist and be transmitted in this area. Many other TDR survey studies in China have reported major TDR mutation clusters (Zhao et al, 2015); however, no such major mutations were detected in our study. This might be due to the fact that the drug-naïve cases in the present study were not newly infected, so that major mutations (if any) would have had enough time to be outcompeted by the wild type because of their fitness cost when the drug pressure was removed.…”

Section: Discussioncontrasting

confidence: 93%

Drug resistance mutation profiles of the drug-naïve and first-line regimen-treated HIV-1-infected population of Suzhou, China

Feng

Yuan

et al. 2017

Virol. Sin.

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Little is known about the prevalence of drug-resistant mutations in HIV-1-positive individuals in Suzhou, China. To elucidate the transmitted drug resistance (TDR) and acquired drug resistance mutation (ADR) profiles, we collected blood specimens from 127 drug-naïve and 117 first-line drug-treated HIV-1-infected individuals sampled from 2014 to 2016 in Suzhou. We successfully amplified pol fragments from 100 drug-naïve and 20 drug-treated samples. We then determined the drug-resistant mutations to protease (PR) and reverse-transcriptase (RT) inhibitors according to the Stanford drug resistance database. Overall, 11 and 13 individuals had transmitted (drug-naïve group) and acquired (treated group) resistance mutations, respectively. Six transmitted drug-resistant mutations were found, including two mutations (L33F and L76V) in the protease region and four (K70N/E and V179D/E) in the RT region. Only L76V was a major mutation, and K70N/E and V179D/E are known to cause low-level resistance to RT inhibitors. All 13 treated participants who had major drug resistance mutations demonstrated intermediate to high resistance to efavirenz and nevirapine, and six had a treatment duration of less than three months. No major mutations to RT inhibitors were found, implying that the epidemic of transmitted resistance mutations was not significant in this area. Our results suggest that more frequent virus load and drug resistance mutation tests should be conducted for individuals receiving antiretroviral treatment, especially for newly treated patients. Our research provides insights into the occurrence of HIV-1 drug resistance in Suzhou and will help to optimize the treatment strategy for this population.

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Section: Discussioncontrasting

confidence: 93%

Drug resistance mutation profiles of the drug-naïve and first-line regimen-treated HIV-1-infected population of Suzhou, China

Feng

Yuan

et al. 2017

Virol. Sin.

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“…All codons associated with antiretroviral drug resistance were included in this study. Previous studies have shown that the transmission of drug resistance in Shenyang occurs at a low rate (Zhao et al, 2011;Zhao, 2015). We removed codons associated with antiretroviral drug resistance and found that the results were unchanged (data not shown).…”

Section: Hiv-1 Sequences and Cluster Identificationmentioning

confidence: 85%

Dynamics of HIV-1 Molecular Networks Reveal Effective Control of Large Transmission Clusters in an Area Affected by an Epidemic of Multiple HIV Subtypes

et al. 2020

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“…Previous published studies on TDR investigated in different countries showed that the rates of TDR differs between regions and time period, and the overall rate varies ranging from 0% to 23% in treatment-naïve individuals[ 5 – 9 ]. Although the prevalence of TDR among treatment-naïve HIV-1-infected individuals remains low in most areas of China, some recent reports indicated moderate levels in specific regions[ 10 – 12 ].…”

Section: Introductionmentioning

confidence: 99%

Epidemiological surveillance of HIV-1 transmitted drug resistance among newly diagnosed individuals in Shijiazhuang, northern China, 2014–2015

et al. 2018

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BackgroundThe widespread use of antiretroviral therapy (ART) has led to considerable concerns about the prevalence of transmitted drug resistance (TDR). Sexual contact, particularly men who have sex with men (MSM) was the most prevalent form of HIV transmission in Shijiazhuang. Hence, we conducted an epidemiological surveillance study on TDR among newly diagnosed individuals who infected-HIV through sexual contact in from 2014–2015.MethodsGenotypic resistance mutations were defined using the WHO-2009 surveillance list. Potential impact on antiretroviral drug was predicted according to the Stanford HIV db program version 7.0. The role of transmission clusters in drug resistant strains was evaluated by phylogenetic and network analyses.ResultsIn this study, 589 individuals were recruited and 542 samples were amplified and sequenced successfully. The over prevalence of TDR was 6.1%: 1.8% to nucleoside reverse transcriptase inhibitors (NRTIs), 2.0% to non- NRTIs (NNRTIs) and 2.4% to protease inhibitors (PIs), respectively. We did not find significant differences in the TDR prevalence by demographic and clinical characteristics (p > 0.05). Using network and phylogenetic analysis, almost 60.0% sequences were clustered together. Of these clusters, 2 included at least two individuals carrying the same resistance mutation, accounting for 21.2% (7/33) individuals with TDR. No significant difference was observed in the clustering rate between the individuals with and without TDR.ConclusionsWe obtained a moderate level TDR rate in studied region. These findings enhance our understanding of HIV-1 drug resistance prevalence in Shijiazhuang, and may be helpful for the comprehensive prevention and control of HIV-1.

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Increase of RT-Related Transmitted Drug Resistance in Non-CRF01_AE Among HIV Type 1–Infected Men Who Have Sex With Men in the 7 Cities of China

Cited by 22 publications

References 23 publications

Drug resistance mutation profiles of the drug-naïve and first-line regimen-treated HIV-1-infected population of Suzhou, China

Drug resistance mutation profiles of the drug-naïve and first-line regimen-treated HIV-1-infected population of Suzhou, China

Dynamics of HIV-1 Molecular Networks Reveal Effective Control of Large Transmission Clusters in an Area Affected by an Epidemic of Multiple HIV Subtypes

Epidemiological surveillance of HIV-1 transmitted drug resistance among newly diagnosed individuals in Shijiazhuang, northern China, 2014–2015

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