Increase of glial fibrillary acidic protein and S-100B in hippocampus and cortex of diabetic rats: effects of vitamin E

Baydaş, Gıyasettin; Недзвецкий, В. С.; Tuzcu, Mehmet; Yasar, Abdullah; Кириченко, С. В.

doi:10.1016/s0014-2999(03)01294-9

Cited by 128 publications

(101 citation statements)

References 26 publications

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“…Our result is similar to previous studies Baydas et al, 2003a;Revsin et al;Baydas et al, 2003b). Revsin et al study showed that one month after STZ treatment, the number of astrocytes significantly increased in the STZtreated group as compared to the vehicle treated group.…”

Section: Discussionsupporting

confidence: 93%

“…The alterations of astrocytes number are possibly due to oxidative stress (Baydas et al, 2003b) and free radical formation (Baydas et al, 2003a). Also Baydas study showed that the gliosis that occurs in diabetes mellitus is mediated, at least indirectly, by free radical formation and antioxidants (Baydas et al, 2003a).…”

Section: Discussionmentioning

confidence: 98%

“…Also Baydas study showed that the gliosis that occurs in diabetes mellitus is mediated, at least indirectly, by free radical formation and antioxidants (Baydas et al, 2003a).…”

Section: Discussionmentioning

confidence: 99%

“…Some researches have indicated that diabetes led to astroglial alterations as increasing of number of astrocytes Baydas et al, 2003a;Revsin et al;Baydas et al, 2003b).…”

Section: Introductionmentioning

confidence: 99%

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Alteration of Dentate Gyrus Astrocytes in Diabetic Rats: Protective Role of Urtica dioica

et al. 2011

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GOLALIPOUR, M. J.; GHAFARI, S.; LATIFIMOGHADAM, M. H. & KABOLI, S.Alteration of dentate gyrus astrocytes in diabetic rats: Protective role of Urtica dioica. Int. J. Morphol., 29(4):1307-1312, 2011. SUMMARY:Diabetes mellitus can cause astrocytes alterations in the central nervous system. Urtica dioica (Nettle) is among several species listed for their use against diabetes in folk medicine. Therefore, this study was done to evaluate the protective effect of Urtica dioica on astrocytes density of the dentate gyrus in STZ induced diabetic rats. In this experimental study, 21 male albino Wistar rats were randomly allocated equally into normal, diabetic and protective (nettle treated diabetic) groups. Hyperglycemia was induced by streptozotocin (80 mg/kg) in the animals of diabetic and treatment groups. Before induction of diabetes in animals, animals in protective group received hydroalcoholic extract of Urtica dioica (100 mg/kg/BW /day) for five days intraperitoneally. Four weeks after induction of diabetes, animals were sacrificed and coronal sections were taken from the dorsal hippocampal formation of the right cerebral hemispheres and stained with PTAH stain. The area densities of the astrocytes were measured and compared in the three groups (p < 0.05). The number of astrocytes in DG area of controls was 17.72±6.7. The density of astrocytes increased in diabetic (24.26±9.5) in comparison with controls. The density in the nettle treated rats (23.17±5.8) was lower than diabetic rats. This study showed that the administration of U. dioica extract before induction of diabetes can not significantly help compensate for astrocytes in the dentate gyrus of treated rats.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 98%

“…Also Baydas study showed that the gliosis that occurs in diabetes mellitus is mediated, at least indirectly, by free radical formation and antioxidants (Baydas et al, 2003a).…”

Section: Discussionmentioning

confidence: 99%

“…Some researches have indicated that diabetes led to astroglial alterations as increasing of number of astrocytes Baydas et al, 2003a;Revsin et al;Baydas et al, 2003b).…”

Section: Introductionmentioning

confidence: 99%

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Alteration of Dentate Gyrus Astrocytes in Diabetic Rats: Protective Role of Urtica dioica

et al. 2011

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“…Increased astrocyte-specific glial fibrillary acidic protein (GFAP) expression has been found in the cortex and hippocampus of STZ-induced diabetic rats [17]. In addition, Glu uptake has been decreased in the brain [18], whereas neurotransmitter homeostasis has been impaired in the hippocampus [19].…”

Section: Introductionmentioning

confidence: 99%

Alteration of Interaction Between Astrocytes and Neurons in Different Stages of Diabetes: a Nuclear Magnetic Resonance Study Using [1-13C]Glucose and [2-13C]Acetate

et al. 2014

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Increasing evidence has shown that the brain is a site of diabetic end-organ damage. This study investigates cerebral metabolism and the interactions between astrocytes and neurons at different stages of diabetes to identify the potential pathogenesis of diabetic encephalopathy. [1-13 C]glucose or [2-13 C]acetate is infused into 1-and 15-week diabetic rats, the brain extracts of which are analyzed by using 1 H and 13 C magnetic resonance spectroscopy. The 13 C-labeling pattern and enrichment of cerebral metabolites are also investigated. The increased 13 C incorporation in the glutamine, glutamate, and γ-aminobutyric acid carbons from [2-13 C]acetate suggests that the astrocytic mitochondrial metabolism is enhanced in 1-week diabetic rats. By contrast, the decreased labeling from [1-13 C]glucose reflected that the neuronal mitochondrial metabolism is impaired. As diabetes developed to 15 weeks, glutamine and glutamate concentrations significantly decreased. The increased labeling of glutamine C4 but unchanged labeling of glutamate C4 from [2-13 C]acetate suggests decreased astrocyte supply to the neurons. In addition, the enhanced pyruvate recycling pathway manifested by the increased lactate C2 enrichment in 1-week diabetic rats is weakened in 15-week diabetic rats. Our study demonstrates the overall metabolism disturbances, changes in specific metabolic pathways, and interaction between astrocytes and neurons during the onset and development of diabetes. These results contribute to the mechanistic understanding of diabetes pathogenesis and evolution.

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Alteration of Glial Fibrillary Acidic Proteins Immunoreactivity in Astrocytes of the Spinal Cord Diabetic Rats

Afsari

Renno

Abd-El-Basset

2008

The Anatomical Record

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Diabetes affects retinal and nervous glial cells, especially the astrocytes. A key indicator of this response is the alteration in the level of intermediate filament glial fibrillary acidic protein (GFAP) and number of GFAP-immunoreactive astrocytes. To date, no study has investigated the effect of diabetes on the distribution of GFAP-immunoreactive astrocytes in the spinal cord. Therefore, the present study investigated the effect of diabetes on the number of GFAP-immunoreactive astrocytes in the gray matter of the spinal cord of streptozotocin-induced diabetic Wistar rats. Animals were divided into six groups (n 5 7); 6 weeks and 12 weeks diabetic duration groups and their respective age-matched normal control and sham control groups. Our results demonstrated a significant (P < 0.001) decrease in the number of GFAP-immunoreactive astrocytes in different areas of the spinal cord sections of the 6 weeks and 12 weeks long diabetic rats when compared with the spinal cord of normal and sham control groups of comparable age. The mean percentage in total number of GFAP-immunoreactive astrocytes in the whole gray matter areas of the spinal cord of the 6 and 12 weeks diabetic groups were approximately 28% and 41% less than control groups. Furthermore, the 12 weeks diabetic group showed a significant (P < 0.001) reduction in the number of GFAP-immunoreactive astrocytes when compared with the 6 weeks diabetic animals. These results suggest that the induction of diabetes is associated with a reduction in GFAP-positive astrocytes in the spinal cord, which may affect the functional support and role of astrocytic cells in the nervous tissue. This in turn may contribute to the pathological changes associated with diabetic state in the central nervous system. Anat

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Increase of glial fibrillary acidic protein and S-100B in hippocampus and cortex of diabetic rats: effects of vitamin E

Cited by 128 publications

References 26 publications

Alteration of Dentate Gyrus Astrocytes in Diabetic Rats: Protective Role of Urtica dioica

Alteration of Dentate Gyrus Astrocytes in Diabetic Rats: Protective Role of Urtica dioica

Alteration of Interaction Between Astrocytes and Neurons in Different Stages of Diabetes: a Nuclear Magnetic Resonance Study Using [1-13C]Glucose and [2-13C]Acetate

Alteration of Glial Fibrillary Acidic Proteins Immunoreactivity in Astrocytes of the Spinal Cord Diabetic Rats

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