Increase of circulating neutrophil and platelet microparticles during acute vasculitis and hemodialysis

Daniel, Laurent; Fakhouri, Fádi; Joly, D; Mouthon, Luc; Nusbaum, Patrick; Jp, Grünfeld; Schifferli, Jürg A.; Guillevin, Loı̈c; Lesavre, Philippe; Halbwachs‐Mecarelli, Lise

doi:10.1038/sj.ki.5000306

Cited by 148 publications

(137 citation statements)

References 51 publications

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“…A previous study demonstrated that, even in patients with severe CKD (end-stage renal disease on hemodialysis), the circulating MP levels were significantly increased only in the presence of reduced whole blood viscosity and shearing stress 42) . Other authors have documented elevated levels of MPs due to acute vascular damage, rather than chronic vasculitis, resulting from renal disease 43) . In the present study, all patients with CKD-AP had chronic kidney vascular disease associated with CKD.…”

Section: Conflicts Of Interestmentioning

confidence: 99%

“…These particles circulate in the blood and have the ability to mediate both inflammation and thrombosis [25][26][27][28][29][30] . Increased numbers of circulating MPs have been reported in a wide range of diseases 25) , including acute coronary syndrome 31) , infectious diseases 32) , diabetes mellitus 33) , uremia 34) and hematologic 35,36) and other malignancies 37,38) . However, it is not currently known whether MPs may be used as biomarkers for predicting the presence of CRS and/or cardiorenal disease (CRD).…”

Section: Blood Sampling For Biochemistry Blood Cell Count Study and mentioning

confidence: 99%

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Levels of Circulating Microparticles in Patients with Chronic Cardiorenal Disease

Chen

Wallace

et al. 2015

JAT

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Aim: Cardiac and renal diseases are common disorders that frequently coexist. We tested the hypothesis that the levels of circulating endothelial-derived apoptotic microparticles (EDA-MPs; CD31 CD42b AN V ) and platelet-derived apoptotic microparticles (PDA-MPs; CD31 CD42b AN V ) are useful biomarkers for predicting the presence of cardiorenal disease (CRD). Methods: A total of 68 patients with chronic kidney disease (CKD) and angina pectoris (CKD-AP) undergoing cardiac catheterization were prospectively enrolled into group 1, 10 patients with coronary artery disease (CAD) without CKD were enrolled into group 2 (CAD CKD ) and 10 patients without CAD and CKD were enrolled into group 3 (CAD CKD ). Results: The serum creatinine levels were significantly higher, whereas the estimated glomerular filtration rates (eGFRs) were significantly lower, in group 1 than in the other two groups (all p 0.02). The circulating levels of EDA-MPs and PDA-MPs did not differ between the patients with and without CKD (all p 0.2). However, the circulating levels of EDA-MPs and PDA-MPs were significantly higher in group 2 than in groups 1 and 3 (all p 0.03). In addition, differences were noted in the circulating EDA-MP and PDA-MP levels between groups 1 and 3, although without statistical significance (all p 0.09). Meanwhile, among the CKD patients, the subgroup analysis showed that the levels of MPs were significantly higher in those with CAD than in those without (all p 0.001), while a multivariate analysis demonstrated that CAD was the only factor independently predictive of high levels of circulating EDA-MPs and PDA-MPs (p 0.033). Conclusions:The link with increased circulating levels of MPs is more consistent in patients with CAD than in those with CKD. J Atheroscler Thromb, 2015; 22: 247-256.

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Section: Conflicts Of Interestmentioning

confidence: 99%

Section: Blood Sampling For Biochemistry Blood Cell Count Study and mentioning

confidence: 99%

Levels of Circulating Microparticles in Patients with Chronic Cardiorenal Disease

Chen

Wallace

et al. 2015

JAT

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“…Circulating MPs have been the most studied EVs in humans with CKD and ESRD, conditions in which MPs have been associated with endothelial dysfunction, 67 cardiovascular mortality, 68,69 increased risk for calcification, 70,71 anemia, 72,73 and disease-specific alteration in coagulation. 74 In a study of a heterogeneous group of patients with chronic renal failure and those on peritoneal dialysis and hemodialysis, all patients compared with healthy controls had higher levels of endothelial-derived microparticles (EMPs) and MPs of leukocyte origin.…”

Section: Ckd/uremia/esrdmentioning

confidence: 99%

Extracellular Vesicles in Renal Diseases

Erdbrügger

2016

Journal of the American Society of Nephrology

165

175

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Extracellular vesicles from the urine and circulation have gained significant interest as potential diagnostic biomarkers in renal diseases. Urinary extracellular vesicles contain proteins from all sections of the nephron, whereas most studied circulating extracellular vesicles are derived from platelets, immune cells, and the endothelium. In addition to their diagnostic role as markers of kidney and vascular damage, extracellular vesicles may have functional significance in renal health and disease by facilitating communication between cells and protecting against kidney injury and bacterial infection in the urinary tract. However, the current understanding of extracellular vesicles has derived mostly from studies with very small numbers of patients or in vitro data. Moreover, accurate assessment of these vesicles remains a challenge, in part because of a lack of consensus in the methodologies to measure extracellular vesicles and the inability of most techniques to capture the entire size range of these vesicles. However, newer techniques and standardized protocols to improve the detection of extracellular vesicles are in development. A clearer understanding of the composition and biology of extracellular vesicles will provide insights into their pathophysiologic, diagnostic, and therapeutic roles.

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“…Most of the data on PMN-derived EVs (called in these studies ectosomes) come from the laboratory of Dr. Schifferli [26,[34][35][36]39,40,45,[93][94][95][96]. They characterized the size and surface properties of EVs released upon fMLP-stimulation and came to the conclusion that both the in vitro and the in vivo generated EVs are right-side out [39,45].…”

Section: Role Of Pmn-derived Vesicles In Communicationmentioning

confidence: 99%