Increase of Brain Tryptophan caused by Drugs which stimulate Serotonin Synthesis

Tagliamonte, A.; Tagliamonte, P.; Pérez-Cruet, Jorge; Gessa, Gian Luigi

doi:10.1038/newbio229125a0

Cited by 68 publications

(13 citation statements)

References 3 publications

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“…Several studies suggest that in mammals the availability of brain Try (and therefore, 5-HT synthesis) can be influenced by serum Try levels (Tagliamonte et al 1971;Fernstrom andWurtman 1971, 1972;Curzon and Fernando 1976) and, mainly by the free plasma Try (Tagliamonte et al 1973;Gessa and Tagliamonte 1974;Aldegunde et al 1980Aldegunde et al , 1986. In the present work, the value of total serum Try was similar to the plasma free Try concentration, suggesting that in adult 0. mykiss, most Try is free, and not protein-bound.…”

Section: Discussionsupporting

confidence: 64%

Distribution of 5-hydroxytryptamine and related compounds in various brain regions of rainbow trout (Oncorhynchus mykiss)

Rozas

Rey

Andrés

et al. 1990

Fish Physiol Biochem

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The levels of tryptophan (Try), 5-hydroxytryptamine (serotonin, 5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) were determined in the brain regions of rainbow trout (Oncorhynchus mykiss) by high performance liquid chromatography with electrochemical detection (HPLC-EC). Brain tryptophan concentrations varied from 3.972 ± 357 ng/g cerebellum) to 8.841 ± 772 ng/g (hypothalamus). The 5-HT concentrations varied from 69 ± 7 ng/g (optic tectum) to 573 ± 34 ng/g (hypothalamus). The concentrations of 5-HIAA varied from 29 ± 3 ng/g (medulla oblongata) to 68 ± 7 ng/g (hypothalamus). Total and free serum tryptophan levels were also determined; in adult rainbow trout 92% of the serum tryptophan was observed to be free i.e., not protein-bound.

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Section: Discussionsupporting

confidence: 64%

Distribution of 5-hydroxytryptamine and related compounds in various brain regions of rainbow trout (Oncorhynchus mykiss)

Rozas

Rey

Andrés

et al. 1990

Fish Physiol Biochem

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“…These experiments also illustrate particularly with reference to tryptophan, the dangers of regarding total plasma or brain concentrations as indicative of the quality of substance available for transport or metabolism. Thus it is na1ve to relate such concentrations to the in vitro determined Km values of their metabolizing enzymes or to imply that alteration in total concentration of substrate in whole brain must necessarily alter significantly the rate of subsequent neuronal metabolism (Tagliamonte, Tagliamonte, Perez-Cruet & Gessa, 1971 …”

Section: Discussionmentioning

confidence: 99%

Interaction in the cerebral metabolism of the biogenic amines: Effect of intravenous infusion of l‐tryptophan on tryptophan and tyrosine in brain and body fluids

Moir

1971

British J Pharmacology

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Summary1. The distribution of the amino-acids tryptophan and tyrosine has been determined in plasma ultrafiltrate, whole plasma, erythrocytes, cerebrospinal fluid (c.s.f.) and various regions of the brain in dogs. 2. The effect of tryptophan administration on the distribution of both these amino-acids showed that the alterations produced in tryptophan concentration did not appear to change the concentrations of tyrosine from their normal pattern. 3. The implications of these results with regard to amino-acid transport systems in man and dog are discussed. IntroductionInteraction between the cerebral metabolism of tryptophan and dopamine has been demonstrated in dog brain (Moir, 1969;Moir & Yates, 1970;Moir, 1971). It was thought initially, in view of the experiments of Guroff & Udenfriend (1962) demonstrating that tryptophan inhibited the rate of uptake of radioactive tyrosine into rat brain, that the interaction demonstrated between the metabolism of the biogenic amines might be due to an interaction between their precursor amino-acids tryptophan and tyrosine. Because of this, concurrent estimations of these aminoacids were made in samples of various body fluids and brain regions during the experiments reported by Moir, 1971. These results are reported separately, as although they demonstrate many interesting features of the behaviour of the amino-acids, tryptophan and tyrosine, in brain and body fluids, they provide no evidence of any interaction between them.

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“…Previous studies demonstrated that the measurements of Trp and 5-HIAA in CSF may provide a useful index of the brain turnover of Trp or 5-HT, respectively [11][12][13][14][15][16][17][18]. It is assumed that the substances secreted from the brain in the different ventricular compartments and reaching the CSF derive from the surrounding nervous tissue.…”

Section: Discussionmentioning

confidence: 99%

Tryptophan metabolism via serotonin in human CSF of different brain sites using a new neuroendoscopic technique

Longatti

Comai

Perin

et al. 2007

International Congress Series

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Increase of Brain Tryptophan caused by Drugs which stimulate Serotonin Synthesis

Cited by 68 publications

References 3 publications

Distribution of 5-hydroxytryptamine and related compounds in various brain regions of rainbow trout (Oncorhynchus mykiss)

Distribution of 5-hydroxytryptamine and related compounds in various brain regions of rainbow trout (Oncorhynchus mykiss)

Interaction in the cerebral metabolism of the biogenic amines: Effect of intravenous infusion of l‐tryptophan on tryptophan and tyrosine in brain and body fluids

Tryptophan metabolism via serotonin in human CSF of different brain sites using a new neuroendoscopic technique

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