Increase in the vasorelaxant potency of KATP channel opening drugs by adenosine A1 and A2 receptors in the pig coronary artery

Davie, Christina; Everitt, Diane E.; Standen, N B

doi:10.1016/s0014-2999(99)00635-4

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…More recently, it has been shown that adenosine receptor activation can enhance the potency of cromakalim via A 2A receptors, but not that of pinacidil (Davie et al, 1999). Although no comparable studies have been carried out in bladder smooth muscle, it raises the possibility that the sensitivity of K ATP channel openers could be enhanced under metabolically compromised conditions, where adenosine release is higher, as for example, in bladder instability subsequent to partial outlet obstruction.…”

Section: Discussionmentioning

confidence: 99%

Functional Characterization of Adenosine Receptors and Coupling to ATP-Sensitive K⁺ Channels in Guinea Pig Urinary Bladder Smooth Muscle

Gopalakrishnan¹,

Buckner²,

Milicic³

et al. 2002

J Pharmacol Exp Ther

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Although multiple adenosine receptors have been identified, the subtype and underlying mechanisms involved in the relaxation response to adenosine in the urinary bladder remain unclear. The present study investigates changes in the membrane potential, as assessed by fluorescence-based techniques, of bladder smooth muscle cells by adenosine receptor agonists acting via ATP-sensitive potassium (K ATP ) channels. Membrane hyperpolarization evoked by adenosine and various adenosine receptor subtype-selective agonists was attenuated or reversed by the K ATP channel blocker glyburide. Comparison of adenosine receptor agonist potencies eliciting membrane potential effects showed a rank order of potency 5Ј-N-ethylcarboxamido adenosine (NECA; Ϫlog EC 50 ϭ 7.97) ϳ 2-p-(2-carboxethyl)phenethyl-amino-5Ј-N-ethylcarboxamidoadenosine hydrochloride (CGS-21680; 7.65) Ͼ 2-chloro adenosine (5.90) ϳ 2-chloro- Collectively, these studies demonstrate that adenosine-evoked membrane hyperpolarization and relaxation of bladder smooth muscle is mediated by A 2A receptor-mediated activation of K ATP channels via adenylate cyclase and elevation of cAMP.

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Section: Discussionmentioning

confidence: 99%

Functional Characterization of Adenosine Receptors and Coupling to ATP-Sensitive K⁺ Channels in Guinea Pig Urinary Bladder Smooth Muscle

Gopalakrishnan¹,

Buckner²,

Milicic³

et al. 2002

J Pharmacol Exp Ther

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Unusual causes of hypokalaemia and paralysis

Alazami¹,

Lin²,

Cheng³

et al. 2006

QJM

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We demonstrate how the application of physiological principles may help to identify unusual causes of a very low plasma potassium (K+) concentration (P(K)) and paralysis. In the two patients described, the short time course of the illness suggested that there was an acute shift of K+ into cells. The combination of a low rate of excretion of K+, the absence of a metabolic acid-base disorder, and the fact that the clinical findings occurred very soon after a large intake of carbohydrate supported this impression. Surprisingly, the P(K) remained low for many hours after these stimuli to shift K+ into cells had abated. The missing link in this story was eventually provided by the attending medical team with the help of their mentor, Professor McCance.

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Isoflurane Sensitizes the Cardiac Sarcolemmal Adenosine Triphosphate–Sensitive Potassium Channel to Pinacidil

Gassmayr

Stadnicka²,

Suzuki

et al. 2003

Anesthesiology

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Increase in the vasorelaxant potency of KATP channel opening drugs by adenosine A1 and A2 receptors in the pig coronary artery

Cited by 3 publications

References 28 publications

Functional Characterization of Adenosine Receptors and Coupling to ATP-Sensitive K⁺ Channels in Guinea Pig Urinary Bladder Smooth Muscle

Functional Characterization of Adenosine Receptors and Coupling to ATP-Sensitive K⁺ Channels in Guinea Pig Urinary Bladder Smooth Muscle

Unusual causes of hypokalaemia and paralysis

Isoflurane Sensitizes the Cardiac Sarcolemmal Adenosine Triphosphate–Sensitive Potassium Channel to Pinacidil

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Increase in the vasorelaxant potency of KATP channel opening drugs by adenosine A1 and A2 receptors in the pig coronary artery

Cited by 3 publications

References 28 publications

Functional Characterization of Adenosine Receptors and Coupling to ATP-Sensitive K+ Channels in Guinea Pig Urinary Bladder Smooth Muscle

Functional Characterization of Adenosine Receptors and Coupling to ATP-Sensitive K+ Channels in Guinea Pig Urinary Bladder Smooth Muscle

Unusual causes of hypokalaemia and paralysis

Isoflurane Sensitizes the Cardiac Sarcolemmal Adenosine Triphosphate–Sensitive Potassium Channel to Pinacidil

Contact Info

Product

Resources

About

Functional Characterization of Adenosine Receptors and Coupling to ATP-Sensitive K⁺ Channels in Guinea Pig Urinary Bladder Smooth Muscle

Functional Characterization of Adenosine Receptors and Coupling to ATP-Sensitive K⁺ Channels in Guinea Pig Urinary Bladder Smooth Muscle