Increase in the level of oral neutrophils with gingival inflammation – A population survey

Sreenivasan, Prem K.; Prasad, K V V

doi:10.1016/j.sdentj.2022.11.004

“…A case-control study indicated that periodontitis patients suffered from a higher level of apoptotic circulatory neutrophils than healthy people (Nicu et al, 2018 ). An increased neutrophil count could suggest the inflammatory burden of gingivitis and dental plaque in the oral cavity (Sreenivasan and Prasad, 2022 ). Another study discovered that neutrophil depletion ameliorated experimental periodontitis while unrestrained recruitment aggravated it (Dutzan et al, 2018 ).…”

Section: Circulating Neutrophils Play a Significant Part In Periodont...mentioning

confidence: 99%

Genetic associations between circulating immune cells and periodontitis highlight the prospect of systemic immunoregulation in periodontal care

Ye,

Bai,

Li

et al. 2024

eLife

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Periodontitis drives irreparable destruction of periodontal tissue and possesses a tendency to aggravate inflammatory disorders. Systemic immunomodulation management remains an attractive approach in periodontal care within a context of “predictive, preventive, and personalized” periodontics. Leveraging a comprehensive Mendelian randomization (MR), the present study aims to evaluate the causal relationships between circulating immune cells and the risk of periodontitis. Genetic proxies for circulating immune cells and periodontitis were obtained from genome-wide association studies. We performed a two-sample bidirectional univariable Mendelian Randomization, followed by sensitivity testing, multivariable MR, subgroup analysis, and Bayesian model averaging (MR-BMA) to explore the causal association between them. The transcriptome-wide association study (TWAS) and colocalization analysis were further conducted to identify responsible genes as immunomodulation candidates for periodontal care. MR study indicated that circulating neutrophils, Natural Killer T cells, and plasmacytoid Dendritic Cells were relative to a higher risk of periodontitis, with no evidence of heterogeneity or pleiotropy. The MR-BMA identified neutrophils as the primary factor responsible for periodontitis. The TWAS recognized five cross-trait genes to be involved in their interaction. Two high-confidence genes on 1q21.3, S100A9 and S100A12, could represent immunomodulation targets for neutrophils in periodontitis. The present study suggests the causative association between circulating immune cells and the risk of periodontitis. Our findings highlight the prospect of systemic immunomodulation management in periodontal care, which can be valuable for early diagnostics, risk assessment, targeted prevention, and personalized management of periodontitis. More research is required to comprehend the biological plausibility and clinical applicability of our findings. This work was supported by the Major Program of National Natural Science Foundation of China (No. 81991500 & 81991502), the Fundamental Research Funds for the Central Universities (No. 226-2023-00121 & 226-2022-00213), Zhejiang University Global Partnership Fund (No. 188170 & 194452307/004) and the Joint Funds of the Zhejiang Provincial Natural Science Foundation of China (No. LHDMD23H300001)

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“…A casecontrol study indicated that periodontitis patients suffered from a higher level of apoptotic circulatory neutrophils than healthy people (Nicu et al, 2018 ). An increased neutrophil count could suggest the inflammatory burden of gingivitis and dental plaque in the oral cavity (Sreenivasan and Prasad, 2022 ). Another study discovered that neutrophil depletion ameliorated experimental periodontitis while unrestrained recruitment aggravated it (Dutzan et al, 2018 ).…”

Section: Circulating Neutrophils Play a Significant Part In Periodont...mentioning

confidence: 99%

Association between genetically predicted circulating immune cells on periodontitis highlights the prospect of systemic immunomodulation management in periodontal care: a Mendelian randomization study

Ye,

Bai,

Li

et al. 2023

Preprint

0

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Periodontitis drives irreparable destruction of periodontal tissue and possesses a tendency to aggravate inflammatory disorders. Systemic immunomodulation management remains an attractive approach in periodontal care within a context of “predictive, preventive, and personalized” periodontics. Leveraging a comprehensive Mendelian randomization (MR), the present study aims to evaluate the causal relationships between circulating immune cells and the risk of periodontitis. Genetic proxies for circulating immune cells and periodontitis were obtained from genome-wide association studies. We performed a two-sample bidirectional univariable Mendelian Randomization, followed by sensitivity testing, multivariable MR, subgroup analysis, and Bayesian model averaging (MR-BMA) to explore the causal association between them. The transcriptome-wide association study (TWAS) and colocalization analysis were further conducted to identify responsible genes as immunomodulation candidates for periodontal care. MR study indicated that circulating neutrophils, Natural Killer T cells, and plasmacytoid Dendritic Cells were relative to a higher risk of periodontitis, with no evidence of heterogeneity or pleiotropy. The MR-BMA identified neutrophils as the primary factor responsible for periodontitis. The TWAS recognized five cross-trait genes to be involved in their interaction. Two high-confidence genes on 1q21.3, S100A9 and S100A12, could represent immunomodulation targets for neutrophils in periodontitis. The present study suggests the causative association between circulating immune cells and the risk of periodontitis. Our findings highlight the prospect of systemic immunomodulation management in periodontal care, which can be valuable for early diagnostics, risk assessment, targeted prevention, and personalized management of periodontitis. More research is required to comprehend the biological plausibility and clinical applicability of our findings. This work was supported by the Major Program of National Natural Science Foundation of China (No. 81991500 & 81991502), the Fundamental Research Funds for the Central Universities (No. 226-2023-00121 & 226-2022-00213), Zhejiang University Global Partnership Fund (No. 188170 & 194452307/004) and the Joint Funds of the Zhejiang Provincial Natural Science Foundation of China (No. LHDMD23H300001)

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Detection and consistency of mucosal fluid T lymphocyte phenotypes and their relationship with blood, age and gender

Nasab,

Eniya,

Judith

et al. 2024

Journal of Immunological Methods

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Increase in the level of oral neutrophils with gingival inflammation – A population survey

Cited by 6 publications

References 33 publications

Genetic associations between circulating immune cells and periodontitis highlight the prospect of systemic immunoregulation in periodontal care

Genetic associations between circulating immune cells and periodontitis highlight the prospect of systemic immunoregulation in periodontal care

Association between genetically predicted circulating immune cells on periodontitis highlights the prospect of systemic immunomodulation management in periodontal care: a Mendelian randomization study

Detection and consistency of mucosal fluid T lymphocyte phenotypes and their relationship with blood, age and gender

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