Increase in the incidence of gestational trophoblastic disease in The Netherlands

Lybol, Charlotte; Thomas, Chris M.G.; Bulten, Johan; Dijck, J.A.A.M. van; Sweep, Fred C.G.J.; Massuger, Leon F.A.G.

doi:10.1016/j.ygyno.2011.01.002

Cited by 68 publications

(61 citation statements)

References 29 publications

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“…Molar pregnancy is more common in some parts of Asia, with reported incidence rates as high as 2 per 1000 pregnancies [4,5] compared with Europe and North American where the incidence is usually reported to be less than 1 per 1000 pregnancies [6,7]. However, the incidence of molar pregnancy seems to be decreasing in Asian countries, possibly related to improvements in the economy and diet as well as a decrease in birth rates [4].…”

Section: Epidemiologymentioning

confidence: 99%

Update on the diagnosis and management of gestational trophoblastic disease

Ngan

Seckl

Berkowitz

et al. 2015

Intl J Gynecology & Obste

251

403

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Section: Epidemiologymentioning

confidence: 99%

Update on the diagnosis and management of gestational trophoblastic disease

Ngan

Seckl

Berkowitz

et al. 2015

Intl J Gynecology & Obste

251

403

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“…The incidence was 1:2000 pregnancies in Paraguay 3 . Netherlands showed an increasing trend of GTD most likely due to an increase in migrant Asian women giving birth 11 .…”

Section: Discussionmentioning

confidence: 99%

Incidence and clinical outcome of Gestational Trophoblastic diseases in a tertiary care hospital

2017

Int. J. Curr. Res. Med. Sci.

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Introduction: Gestational trophoblastic disease (GTD) consists of group of disorders having pathology of abnormal trophoblastic proliferation ranging from hydatidiform mole to gestational trophoblastic neoplasia. Based on differences in morphology, histopathology, karyotype and clinical features, hydatidiform mole can be categorized into partial and complete moles. Molar pregnancy incidence varies across countries. The incidence of molar pregnancy in Asia is 1:100-300, choriocarcinoma 1:1000-2000 of live born children. Aim: To determine the incidence, clinical outcome and management of women with gestational trophoblastic disease (GTD) at tertiary care hospital during a study period of 6 months. Materials and Methods: This is an observational descriptive study conducted over a period of 6 months. In our study, total 18 cases were diagnosed with GTD, based on ultrasound, biochemical and histological examination. Results: During study period, total patients delivered were 3610, out of which 18 cases had GTD. The overall incidence of GTD was 1/200 pregnancies, including cases of partial mole, complete mole, choriocarcinoma, and invasive mole. Highest incidence was found in extremes of age. 77.7% of cases presented in the first trimester, while 22.3% of cases presented in the second trimester. 77.7% of cases were complete mole, 11.1% were partial mole, and 11.1% were diagnosed as gestational trophoblastic neoplasm. Majority of cases (94.4%) presented with vaginal bleeding; pregnancy induced hypertension and preeclampsia was present in 16.6% of cases, 66.6% had abdominal cramps, 44.4% presented with signs of dehydration due to hyperemesis gravidarum, 22.2% had hyperthyroidism. Ultrasound was diagnostic in 95% cases, while histopathological examination was diagnostic in 100% of the cases. The incidence of GTDs in our hospital (1 in 200) is comparable to the incidence in Middle East and Far Eastern countries. Conclusion: In our study, we found a high incidence of GTD in primigravidas. Most patients who had been diagnosed with GTD on USG were in first trimester.

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“…Incidenca trofoblastnih sekvela posle molarne trudnoće iznosi 7-31%. Čak i pacijentkinje kojima je urađena histerektomija posle benigne hidatiformne mole, moraju biti praćene, jer se u oko 20% slučajeva mogu razviti maligne sekvele (27,28 Smatra se da kod oko 80% pacijentkinja posle evakuacije hidatiformne mole dolazi do spontane regresije nivoa hCG-a. u 1,8% slučajeva dolazi do regresije u prvih 10 dana posle evakuacije, u 20,8% od 11-30. dana, u 42,8% 31-60. dana, a u 34,6% 61-170. dana posle intervencije.…”

Section: Protokoli Praćenja Efekata Terapije Gestacijskih Trofoblastnunclassified

Treatment and monitoring protocols for gestational trophoblastic disease

Milenkovic¹,

Lazović²

2012

Medicinski casopis

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UVODGestacijske trofoblastne bolesti (GTB) postale su izlečive zahvaljujući efikasnoj hemioterapiji, identifikaciji faktora rizika koji omogućavaju individualizaciju inicijalne terapije i upotrebi senzitivnog testa za određivanje humanog horionskog gonadotropina (hCG). Do uvođenja hemioterapije, 1956. godine, pacijentkinje obolele od GTB lečene su hirurški ili zračnom terapijom (1, 2). Stopa preživljavanja kod ovih bolesti bila je veoma niska, a većina bolesnica umirala je zbog brzog napredovanja oboljenja, u periodu manjem od godinu dana od postavljanja dijagnoze. Sa stalnim usavršavanjem hemioterapije, stope izlečenja pacijentkinja sa nemetastatskom i metastatskom trofoblastnom bolešću dobre prognoze dostigle su i 100%. Čak i pacijentkinje obolele od metastatske bolesti loše prognoze, kombinacijom agresivne hemioterapije uz dodatnu radijaciju i hirurgiju, danas se mogu izlečiti u 60-84% slučajeva (3).Iako je važnost hirurgije kao primarnog metoda lečenja malignih GTB u današnje vreme manja nego ranije, primena hirurških postupaka ostala je vredna dopuna modernoj terapiji ovih oboljenja (4). Operativni tretman ima važnu ulogu kod trofoblastne bolesti rezistentne na hemioterapiju. Lečenjem različitim hemioterapijskim protokolima tokom nekoliko meseci može se eliminisati većina rezidualnih žarišta (5). Na prisustvo perzistentne bolesti i posle lečenja hemioterapeuticima ukazuju povišene vrednosti hCG-a.

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Increase in the incidence of gestational trophoblastic disease in The Netherlands

Cited by 68 publications

References 29 publications

Update on the diagnosis and management of gestational trophoblastic disease

Update on the diagnosis and management of gestational trophoblastic disease

Incidence and clinical outcome of Gestational Trophoblastic diseases in a tertiary care hospital

Treatment and monitoring protocols for gestational trophoblastic disease

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