Increase in serum parathyroid hormone levels after prolonged physical exercise

Ljunghall, Sverker; JOBORN, HENRIK; Roxin, Lars-Eric; Skarfors, Einar; Wide, Leif; Lithell, Hans

doi:10.1249/00005768-198804001-00004

Cited by 12 publications

(12 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the discordance is also likely related to variability in the exercise stimulus, because the disruption of Ca homeostasis appears to be dependent on the duration and intensity of exercise. For example, in an early series of studies of young men by Ljunghall and colleagues, brief high‐intensity exercise caused an increase in serum iCa with no change in PTH, prolonged low‐intensity exercise caused a decrease in serum iCa and increase in PTH, and less prolonged moderate‐intensity exercise tended to increase PTH despite no decrease or an increase in iCa. A more recent series of studies of young men by Scott and colleagues and Townsend and colleagues confirmed that the PTH response to exercise is intensity dependent (ie, higher intensity, higher PTH response).…”

Section: Discussionmentioning

confidence: 99%

Maintenance of Serum Ionized Calcium During Exercise Attenuates Parathyroid Hormone and Bone Resorption Responses

Kohrt

Wherry

Wolfe

et al. 2018

Journal of Bone and Mineral Research

View full text Add to dashboard Cite

Exercise can cause a decrease in serum ionized calcium (iCa) and increases in parathyroid hormone (PTH) and bone resorption. We used a novel intravenous iCa clamp technique to determine whether preventing a decline in serum iCa during exercise prevents increases in PTH and carboxy-terminal collagen crosslinks (CTX). Eleven cycling-trained men (aged 18 to 45 years) underwent two identical 60-min cycling bouts with infusion of Ca gluconate or saline. Blood sampling for iCa, total calcium (tCa), PTH, CTX, and procollagen type 1 amino-terminal propeptide (P1NP) occurred before, during, and for 4 hours after exercise; results are presented as unadjusted and adjusted for plasma volume shifts (denoted with subscript ADJ). iCa decreased during exercise with saline infusion (p = 0.01 at 60 min) and this was prevented by Ca infusion (interaction, p < 0.007); there were abrupt decreases in Ca content (iCa and tCa ) in the first 15 min of exercise under both conditions. PTH and CTX were increased at the end of exercise (both p < 0.01) on the saline day, and markedly attenuated (-65% and -71%; both p < 0.001) by Ca. CTX remained elevated for 4 hours after exercise on the saline day (p < 0.001), despite the return of PTH to baseline by 1 hour after exercise. P1NP increased in response to exercise (p < 0.001), with no difference between conditions, but the increase in P1NP was not significant. Results for PTH and CTX were similar to unadjusted results. These findings demonstrate that bone resorption is stimulated early in exercise to defend serum iCa. Vascular Ca content decreased early in exercise, but neither the reason why this occurred, nor the fate of Ca, are known. The results suggest that the exercise-induced increase in PTH had an acute catabolic effect on bone. Future research should determine whether the increase in PTH generates an anabolic response that occurs more than 4 hours after exercise. © 2018 American Society for Bone and Mineral Research.

show abstract

Section: Discussionmentioning

confidence: 99%

Maintenance of Serum Ionized Calcium During Exercise Attenuates Parathyroid Hormone and Bone Resorption Responses

Kohrt

Wherry

Wolfe

et al. 2018

Journal of Bone and Mineral Research

View full text Add to dashboard Cite

show abstract

“…It is known that stress hormones such as epinephrine or glucagon lead to electrolyte redistribution and particularly considerable intracellular phosphate shifts . Intense physical effort has also been found to cause parathormone variations, which lead to transient hypophosphatemia . In the setting of TLOC, this could point to a peak in stress hormones and sustained muscular activity during the episode.…”

Section: Discussionmentioning

confidence: 99%

A potential role of hypophosphatemia for diagnosing convulsive seizures: A case‐control study

et al. 2019

View full text Add to dashboard Cite

Objective Transient loss of consciousness (TLOC) is a common presentation in the emergency room, where patient history can usually differentiate syncope from generalized tonic‐clonic (GTC) seizures. Several serum markers, such as creatine kinase and lactate, can be helpful, especially when history is unreliable. Here, we explore a potential supporting role of electrolyte plasma levels in a case‐control study. Methods In our electroencephalographic database, we retrospectively identified consecutive episodes of loss of consciousness in adults seen over 3 years in our hospital emergency department for a case‐control study. We investigated plasma levels of several electrolytes (sodium, potassium, phosphate, calcium, magnesium) at the emergency visit, as well as demographics, diagnosis, blood‐sample delay time, and history of alcohol abuse. Results Of the 126 patients identified, 75 had GTC seizures and 46 had other TLOC causes. Among electrolyte levels, only hypophosphatemia was associated with GTC seizures (median = 0.79 mmol·L–1, range = 0.34‐1.37 in GTC seizures vs 0.93 mmol·L–1, range = 0.52‐1.56, P = 0.001 in TLOC). After adjusting for blood sampling delay, alcohol abuse, and other electrolyte levels, only hypophosphatemia was associated with GTC seizures, occurring in 37 (51%) of GTC seizures and 12 (22%) of other TLOC (odds ratio = 3.5, 95% confidence interval = 1.5‐8.3, P = 0.003). Hypophosphatemia < 0.6 mmol·L–1 was 93% specific and 20% sensitive for GTC seizure occurrence. In follow‐ups, hypophosphatemia was transitory. Significance Transient hypophosphatemia is common after GTC seizures and could represent an additional biological marker to help differentiate GTC seizures from other TLOC, especially when history is unclear. This hypothesis needs to be tested prospectively.

show abstract

“…PTH in A was lower than in NA, which was consistent with the observation by Durosier et al [ 26 ]. Several studies have demonstrated that PTH concentrations do not change or increase during exercise [ 27 , 30 , 31 , 32 , 33 , 34 ]. Lower concentrations of PTH coupled with higher calcium concentrations in A may indicate that endurance exercise induces permanent suppression of PTH secretion.…”

Section: Discussionmentioning

confidence: 99%

Sclerostin as a novel marker of bone turnover in athletes

et al. 2016

View full text Add to dashboard Cite

Sclerostin is a protein secreted by osteocytes that acts as an inhibitor of bone formation. It has been shown that physical activity affects sclerostin concentration and thus bone remodelling. The aim of the study was to evaluate serum concentrations of sclerostin, selected bone turnover markers (PTH, P1NP), 25(OH)D3 and the intake of calcium and vitamin D in physically active versus sedentary men. A total of 59 healthy men aged 17-37 were enrolled in the study (43 athletes and 16 non-athletes). The mean sclerostin concentration in the group of athletes (A) was significantly higher than in non-athletes (NA) (35.3±8.9 vs 28.0±5.6 pmol·l-1, p= 0.004). A compared with NA had higher concentrations of P1NP (145.6±77.5 vs 61.2±22.3 ng·ml-1, p= <0.0001) and 25(OH)D3 (16.9±8.4 vs 10.3±4.3 ng·ml-1, p= 0.004) and lower concentrations of PTH (25.8±8.3 vs 38.2±11.5 pg·ml-1, p= <0.0001). Vitamin D deficiency was found in 77% of A and 100% of NA. A and NA had similar daily energy intake. They did not differ as to the intake of calcium and vitamin D. We observed a negative correlation between the serum concentrations of sclerostin and calcium in the studied subjects. Our results suggest that regular, long-lasting physical training may be associated with higher concentration of sclerostin. It seems that increased sclerostin is not related to other bone turnover markers (PTH, P1NP).

show abstract

Increase in serum parathyroid hormone levels after prolonged physical exercise

Cited by 12 publications

References 0 publications

Maintenance of Serum Ionized Calcium During Exercise Attenuates Parathyroid Hormone and Bone Resorption Responses

Maintenance of Serum Ionized Calcium During Exercise Attenuates Parathyroid Hormone and Bone Resorption Responses

A potential role of hypophosphatemia for diagnosing convulsive seizures: A case‐control study

Sclerostin as a novel marker of bone turnover in athletes

Contact Info

Product

Resources

About