Increase in serum nerve growth factor but not intervertebral disc degeneration following whole-body vibration in rats

Patterson, Folly; Miralami, Raheleh; Olivier, Alicia K.; McNulty, Kaylin; Wood, John; Prabhu, Raj; Priddy, Lauren B.

doi:10.1016/j.clinbiomech.2022.105823

Cited by 2 publications

(3 citation statements)

References 51 publications

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“…However, long-term repeated exposure to WBV resulted in degeneration of IVD and knee joint using CD-1 mouse, but repeated exposure to WBV in C57BL/6 mouse did not present damage performance for IVD and knee joint (McCann et al, 2015). One possible explanation for the different results is that the resonant frequency may play a role in response to WBV, because the resonant frequency is a function of animal/tissue mass (Rabey et al, 2015;Patterson et al, 2022). Another explanation is that the posture may play an important role in the response to WBV in different type of mouse.…”

Section: Discussionmentioning

confidence: 99%

“…Exposure to the whole-body vibration (WBV) of daily life has been established as a factor in the development of spinal pathologies, such as disc herniation and nerve damage in human beings (Patterson et al, 2021), and spinal segmental injury from WBV is most likely to happen at the resonant frequency. Furthermore, the effects of WBV on IVD and FJ degeneration might be species-dependent, as resonant frequency is a function of animal/tissue mass (Patterson et al, 2022). Within the last decades, high-frequency (20-90 Hz) WBV has been used as a clinical therapy for various diseases including bone fracture, osteoporosis, spinal cord injury, and multiple sclerosis (Rubin et al, 2004;Herrero et al, 2011;Claerbout et al, 2012;Pang et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Long-term whole-body vibration induces degeneration of intervertebral disc and facet joint in a bipedal mouse model

Jin

Yin

et al. 2023

Front. Bioeng. Biotechnol.

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Background: Whole body vibration (WBV) has been used to treat various musculoskeletal diseases in recent years. However, there is limited knowledge about its effects on the lumbar segments in upright posture mice. This study was performed to investigate the effects of axial Whole body vibration on the intervertebral disc (IVD) and facet joint (FJ) in a novel bipedal mouse model.Methods: Six-week-old male mice were divided into control, bipedal, and bipedal + vibration groups. Taking advantage of the hydrophobia of mice, mice in the bipedal and bipedal + vibration groups were placed in a limited water container and were thus built standing posture for a long time. The standing posture was conducted twice a day for a total of 6 hours per day, 7 days per week. Whole body vibration was conducted during the first stage of bipedal building for 30 min per day (45 Hz with peak acceleration at 0.3 g). The mice of the control group were placed in a water-free container. At the 10th-week after experimentation, intervertebral disc and facet joint were examined by micro-computed tomography (micro-CT), histologic staining, and immunohistochemistry (IHC), and gene expression was quantified using real-time polymerase chain reaction. Further, a finite element (FE) model was built based on the micro-CT, and dynamic Whole body vibration was loaded on the spine model at 10, 20, and 45 Hz.Results: Following 10 weeks of model building, intervertebral disc showed histological markers of degeneration, such as disorders of annulus fibrosus and increased cell death. Catabolism genes’ expression, such as Mmp13, and Adamts 4/5, were enhanced in the bipedal groups, and Whole body vibration promoted these catabolism genes’ expression. Examination of the facet joint after 10 weeks of bipedal with/without Whole body vibration loading revealed rough surface and hypertrophic changes at the facet joint cartilage resembling osteoarthritis. Moreover, immunohistochemistry results demonstrated that the protein level of hypertrophic markers (Mmp13 and Collagen X) were increased by long-durationstanding posture, and Whole body vibration also accelerated the degenerative changes of facet joint induced by bipedal postures. No changes in the anabolism of intervertebral disc and facet joint were observed in the present study. Furthermore, finite element analysis revealed that a larger frequency of Whole body vibration loading conditions induced higher Von Mises stresses on intervertebral disc, contact force, and displacement on facet joint.Conclusion: The present study revealed significant damage effects of Whole body vibration on intervertebral disc and facet joint in a bipedal mouse model. These findings suggested the need for further studies of the effects of Whole body vibration on lumbar segments of humans.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Long-term whole-body vibration induces degeneration of intervertebral disc and facet joint in a bipedal mouse model

Jin

Yin

et al. 2023

Front. Bioeng. Biotechnol.

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“…Mechanical sensitivity exhibited a general decline over time across all groups, indicative of a habituation (desensitization) effect. The researchers posit that nerve growth factor may serve as a potential diagnostic biomarker for low back pain induced by WBV [49].…”

Section: Two-week Whole-body Vibration Modelsmentioning

confidence: 99%

Investigation of vehicle-induced whole-body vibration with experimental rat models

Nur HAZAR YAVUZ,

YAVUZ

2023

jrp

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This comprehensive study delves into the profound impact of low frequency whole-body vibrations (WBV) on health, focusing on the utilization of rat models for understanding this complex phenomenon. It highlights the adverse effects of low frequency vehicle vibrations on human health, encompassing musculoskeletal discomfort, fatigue, concentration deficits, potential gastrointestinal issues, hearing impairment, and psychological stress. WBV's influence extends to physiological and cognitive consequences, affecting multiple systems. Prolonged WBV exposure, particularly in the lumbar region, is associated with spinal disorders. To navigate ethical challenges in studying WBV in humans, rat models are crucial tools. These models, with customized parameters, offer insights into various health aspects, including bone density, muscle strength, hormonal responses, cardiovascular parameters, and more. Advantages and disadvantages of using low-frequency vibrations in rat models are discussed. While demonstrating WBV's potential effect in research, further exploration is essential to optimize parameters and applications, always prioritizing ethical considerations and regulations. The article concludes by proposing measures to mitigate vehicle vibration impacts on drivers, emphasizing the collaboration of manufacturers, drivers, and regulators for safer and healthier driving experiences.

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Increase in serum nerve growth factor but not intervertebral disc degeneration following whole-body vibration in rats

Cited by 2 publications

References 51 publications

Long-term whole-body vibration induces degeneration of intervertebral disc and facet joint in a bipedal mouse model

Long-term whole-body vibration induces degeneration of intervertebral disc and facet joint in a bipedal mouse model

Investigation of vehicle-induced whole-body vibration with experimental rat models

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