Increase in Plasma Concentrations of Geranylgeranoic Acid after Turmeric Tablet Intake by Healthy Volunteers

Abstract

Geranylgeranoic acid (GGA) is one of the most potent cancer-preventive acyclic retinoids. GGA has been shown to induce cell death in human hepatoma-derived HuH-7 cells. We have recently reported the natural occurrence of GGA and its related compounds in several medicinal herbs such as turmeric, basil, rosehip, cinnamon and others [Shidoji and Ogawa, J. Lipid Res., 45: 1092–1103, 2004]. In the present study, we performed oral administration of turmeric tablets to healthy volunteers in order to investigate bioavailability of natural GGA. By using liquid chromatography/mass spectrometry, authentic GGA was eluted at a retention time of around 18 min as a negative ion of m/z 303.4. With healthy volunteers, plasma GGA was detected prior to the tablet intake and its concentrations were increased at 2 h after its intake and maintained at higher level until 4 h, suggesting an efficient bioavailability of preformed GGA in the turmeric tablets through oral administration. These results indicated that GGA in the turmeric tablet was absorbed as an intact form from intestinal mucosa. The present study provides a clue to conduct a research for cancer preventive roles of GGA in a number of spices.

Age-dependent decrease of hepatic geranylgeranoic acid and its oral supplementation prevents spontaneous hepatoma in C3H/HeN mice

“…Finally, we examined dietary and pharmacological methods to increase hepatic GGA levels in C3H/HeN mice. Previously, we reported that GGA levels in human serum increased by oral ingestion of turmeric tablets containing natural GGA [36] . And, since we recently found that adding GGA to the diet during breeding of C3H/HeN mice effectively increased the fertility [37] , we decided to first examine whether GGA added to the diet would increase hepatic GGA content.…”

Age-Dependent Decrease in Hepatic Geranylgeranoic Acid Content in C3H/HeN Mice and its Oral Supplementation Prevents Spontaneous Hepatoma

“…Finally, we examined dietary and pharmacological methods to increase hepatic GGA levels in C3H/HeN mice. Previously, we reported that GGA levels in human serum increased by oral www.videleaf.com ingestion of turmeric tablets containing natural GGA [30].…”

Age-Dependent Decrease in Hepatic Geranylgeranoic Acid Content in C3H/HeN Mice and Its Oral Supplementation Prevents Spontaneous Hepatoma

“…Finally, we examined dietary and pharmacological methods to increase hepatic GGA levels in C3H/HeN mice. Previously, we reported that GGA levels in human serum increased by oral ingestion of turmeric tablets containing natural GGA [ 30 ]. Additionally, since we recently found that adding GGA to the diet during breeding of C3H/HeN mice effectively increased fertility [ 31 ], we decided to first examine whether GGA added to the diet would increase hepatic GGA content.…”