Increase in plasma CCL11 (Eotaxin-1) in patients with alcohol dependence and changes during detoxification

Huang, Ming‐Chyi; Chung, Ren‐Hua; Lin, Pei‐Hsuan; Kuo, Hsin‐Wei; Liu, Tung‐Hsia; Chen, Ya-Yun; Chen, Andrew C. H.; Liu, Yuli

doi:10.1016/j.bbi.2021.09.016

Cited by 6 publications

(2 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Circulating CCL11 levels have been shown to be elevated in patients with IBD and are associated with inflammatory disease activity [3,39]. In line with our findings, previous studies have found that chronic alcohol consumption is associated with increased plasma CCL11 levels and is reduced upon alcohol discontinuation [40]. Interestingly, a number of antioxidant substances, including flavonoids, have been shown to suppress eotaxin-1 expression via NFκB-and STAT6-mediated signalling in various human cell lines [41].…”

Section: Discussionsupporting

confidence: 88%

Long-Term Dietary Patterns Are Reflected in the Plasma Inflammatory Proteome of Patients with Inflammatory Bowel Disease

Bourgonje

Bolte²,

Vranckx³

et al. 2022

Nutrients

View full text Add to dashboard Cite

Diet plays an important role in the development and progression of inflammatory bowel disease (IBD, comprising Crohn’s disease (CD) and ulcerative colitis (UC)). However, little is known about the extent to which different diets reflect inflammation in IBD beyond measures such as faecal calprotectin or C-reactive protein. In this study, we aimed to unravel associations between dietary patterns and circulating inflammatory proteins in patients with IBD. Plasma concentrations of 73 different inflammation-related proteins were measured in 454 patients with IBD by proximity extension assay (PEA) technology. Food frequency questionnaires (FFQ) were used to assess habitual diet. Principal component analysis (PCA) was performed to extract data-driven dietary patterns. To identify associations between dietary patterns and plasma proteins, we used general linear models adjusting for age, sex, BMI, plasma storage time, smoking, surgical history and medication use. Stratified analyses were performed for IBD type, disease activity and protein intake. A high-sugar diet was strongly inversely associated with fibroblast growth factor-19 (FGF-19) independent of IBD type, disease activity, surgical history and deviance from recommended protein intake (false discovery rate (FDR) < 0.05). Conversely, a Mediterranean-style pattern was associated with higher FGF-19 levels (FDR < 0.05). A pattern characterised by high alcohol and coffee intake was positively associated with CCL11 (eotaxin-1) levels and with lower levels of IL-12B (FDR < 0.05). All results were replicated in CD, whereas only the association with FGF-19 was significant in UC. Our study suggests that dietary habits influence distinct circulating inflammatory proteins implicated in IBD and supports the pro- and anti-inflammatory role of diet. Longitudinal measurements of inflammatory markers, also postprandial, are needed to further elucidate the diet–inflammation relationship.

show abstract

Section: Discussionsupporting

confidence: 88%

Long-Term Dietary Patterns Are Reflected in the Plasma Inflammatory Proteome of Patients with Inflammatory Bowel Disease

Bourgonje

Bolte²,

Vranckx³

et al. 2022

Nutrients

View full text Add to dashboard Cite

show abstract

“…Also, the specificity of CCL11 to SARS-Cov-2 infection needs to be assessed as age-associated cognitive decline and chronic traumatic encephalopathy are associated with elevated CCL11 [ 68 ]. An elevated level of CCL11 is also seen in other pathological states such as asthma [ 69 ], head injuries [ 70 ], and alcohol dependence [ 71 ]. CCL11 levels can be used to stratify patients to assess the risk of their degree of neuroinflammation.…”

Section: Perspectives and Future Directionsmentioning

confidence: 99%

Role of Microglia, Decreased Neurogenesis and Oligodendrocyte Depletion in Long COVID-Mediated Brain Impairments

Wei,

Liang,

Shetty

2023

Aging and disease

View full text Add to dashboard Cite

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a recent worldwide coronavirus disease-2019 (COVID-19) pandemic. SARS-CoV-2 primarily causes an acute respiratory infection but can progress into significant neurological complications in some. Moreover, patients with severe acute COVID-19 could develop debilitating long-term sequela. Long-COVID is characterized by chronic symptoms that persist months after the initial infection. Common complaints are fatigue, myalgias, depression, anxiety, and “brain fog,” or cognitive and memory impairments. A recent study demonstrated that a mild COVID-19 respiratory infection could generate elevated proinflammatory cytokines and chemokines in the cerebral spinal fluid. This commentary discusses findings from this study, demonstrating that even a mild respiratory SARS-CoV-2 infection can cause considerable neuroinflammation with microglial and macrophage reactivity. Such changes could also be gleaned by measuring chemokines and cytokines in the circulating blood. Moreover, neuroinflammation caused by mild SARS-CoV-2 infection can also impair hippocampal neurogenesis, deplete oligodendrocytes, and decrease myelinated axons. All these changes likely contribute to cognitive deficits in long-COVID syndrome. Therefore, strategies capable of restraining neuroinflammation, maintaining better hippocampal neurogenesis, and preserving oligodendrocyte lineage differentiation and maturation may prevent or reduce the incidence of long-COVID after SARS-CoV-2 respiratory infection.

show abstract

Changes of neurofilament light chain in patients with alcohol dependence following withdrawal and the genetic effect from ALDH2 Polymorphism

Huang

Chung

et al. 2023

Eur Arch Psychiatry Clin Neurosci

View full text Add to dashboard Cite

Increase in plasma CCL11 (Eotaxin-1) in patients with alcohol dependence and changes during detoxification

Cited by 6 publications

References 44 publications

Long-Term Dietary Patterns Are Reflected in the Plasma Inflammatory Proteome of Patients with Inflammatory Bowel Disease

Long-Term Dietary Patterns Are Reflected in the Plasma Inflammatory Proteome of Patients with Inflammatory Bowel Disease

Role of Microglia, Decreased Neurogenesis and Oligodendrocyte Depletion in Long COVID-Mediated Brain Impairments

Changes of neurofilament light chain in patients with alcohol dependence following withdrawal and the genetic effect from ALDH2 Polymorphism

Contact Info

Product

Resources

About