Increase in Peripheral Blood Intermediate Monocytes is Associated with the Development of Recent-Onset Type 1 Diabetes Mellitus in Children

Ren, Xiaohan; Mou, Wenjun; Su, Chang; Chen, Xi; Zhang, Hui; Cao, Bingyan; Li, Xiaoqiao; Wu, Di; Ni, Xin; Gui, Jingang; Gong, Chunxiu

doi:10.7150/ijbs.15659

Cited by 30 publications

(34 citation statements)

References 49 publications

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“…When peripheral blood monocytes from recent-onset T1DM patients were assessed, more CD14 + CD16 + monocytes were found, which was negatively correlated with insulin and C-peptide serum levels. Furthermore, these monocytes showed higher expression of HLA-DR and CD86, and showed an activated proinflammatory phenotype ( 192 – 196 ). In recent-onset T1DM patients, plasma TNFα levels were higher which correlated with CD14 expression ( 197 ).…”

Section: Type 1 Diabetes Mellitus (T1dm)mentioning

confidence: 99%

The Potential Role of Trained Immunity in Autoimmune and Autoinflammatory Disorders

2018

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During induction of trained immunity, monocytes and macrophages undergo a functional and transcriptional reprogramming toward increased activation. Important rewiring of cellular metabolism of the myeloid cells takes place during induction of trained immunity, including a shift toward glycolysis induced through the mTOR pathway, as well as glutaminolysis and cholesterol synthesis. Subsequently, this leads to modulation of the function of epigenetic enzymes, resulting in important changes in chromatin architecture that enables increased gene transcription. However, in addition to the beneficial effects of trained immunity as a host defense mechanism, we hypothesize that trained immunity also plays a deleterious role in the induction and/or maintenance of autoimmune and autoinflammatory diseases if inappropriately activated.

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Section: Type 1 Diabetes Mellitus (T1dm)mentioning

confidence: 99%

The Potential Role of Trained Immunity in Autoimmune and Autoinflammatory Disorders

2018

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“…In humans, circulating monocytes have been sorted into three different subpopulations according to the cell surface expression of CD14 and CD16 [ 1 , 2 ]. The vast majority of circulating monocytes show high expression of CD14 and no expression of CD16 (CD14 high CD16 − ) and constitute the fraction of classical monocytes (CM).…”

Section: Introductionmentioning

confidence: 99%

High-Density Lipoprotein Reduction Differentially Modulates to Classical and Nonclassical Monocyte Subpopulations in Metabolic Syndrome Patients and in LPS-Stimulated Primary Human Monocytes In Vitro

Grün

Manjarrez-Reyna

Gómez-Arauz

et al. 2018

Journal of Immunology Research

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The effect of metabolic syndrome on human monocyte subpopulations has not yet been studied. Our main goal was to examine monocyte subpopulations in metabolic syndrome patients, while also identifying the risk factors that could directly influence these cells. Eighty-six subjects were divided into metabolic syndrome patients and controls. Monocyte subpopulations were quantified by flow cytometry, and interleukin- (IL-) 1β secretion levels were measured by ELISA. Primary human monocytes were cultured in low or elevated concentrations of high-density lipoprotein (HDL) and stimulated with lipopolysaccharide (LPS). The nonclassical monocyte (NCM) percentage was significantly increased in metabolic syndrome patients as compared to controls, whereas classical monocytes (CM) were reduced. Among all metabolic syndrome risk factors, HDL reduction exhibited the most important correlation with monocyte subpopulations and then was studied in vitro. Low HDL concentration reduced the CM percentage, whereas it increased the NCM percentage and IL-1β secretion in LPS-treated monocytes. The LPS effect was abolished when monocytes were cultured in elevated HDL concentrations. Concurring with in vitro results, IL-1β serum values significantly increased in metabolic syndrome patients with low HDL levels as compared to metabolic syndrome patients without HDL reduction. Our data demonstrate that HDL directly modulates monocyte subpopulations in metabolic syndrome.

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“…1D and E). CD16 ϩ CD14 ϩ monocytes increased not only during SIV/HIV infection but also after other various microbiological infections (52)(53)(54). These monocytes possess activated and proinflammatory properties, such as high soluble CD163 production concomitant with increased turnover rates (55) and high CXCL10 expression in secondary lymphoid tissues (56).…”

Section: Discussionmentioning

confidence: 99%

Critical Role for Monocytes/Macrophages in Rapid Progression to AIDS in Pediatric Simian Immunodeficiency Virus-Infected Rhesus Macaques

Sugimoto

Merino

Hasegawa

et al. 2017

J Virol

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Infant humans and rhesus macaques infected with the human or simian immunodeficiency virus (HIV or SIV), respectively, express higher viral loads and progress more rapidly to AIDS than infected adults. Activated memory CD4 T cells in intestinal tissues are major primary target cells for SIV/HIV infection, and massive depletion of these cells is considered a major cause of immunodeficiency. Monocytes and macrophages are important cells of innate immunity and also are targets of HIV/SIV infection. We reported previously that a high peripheral blood monocyte turnover rate was predictive for the onset of disease progression to AIDS in SIV-infected adult macaques. The purpose of this study was to determine if earlier or higher infection of monocytes/macrophages contributes to the more rapid progression to AIDS in infants. We observed that uninfected infant rhesus macaques exhibited higher physiologic baseline monocyte turnover than adults. Early after SIV infection, the monocyte turnover further increased, and it remained high during progression to AIDS. A high percentage of terminal deoxynucleotidyltransferase dUTP nick end label (TUNEL)-positive macrophages in the lymph nodes (LNs) and intestine corresponded with an increasing number of macrophages derived from circulating monocytes (bromodeoxyuridine positive [BrdU] CD163), suggesting that the increased blood monocyte turnover was required to rapidly replenish destroyed tissue macrophages. Immunofluorescence analysis further demonstrated that macrophages were a significant portion of the virus-producing cells found in LNs, intestinal tissues, and lungs. The higher baseline monocyte turnover in infant macaques and subsequent macrophage damage by SIV infection may help explain the basis of more rapid disease progression to AIDS in infants. HIV infection progresses much more rapidly in pediatric cases than in adults; however, the mechanism for this difference is unclear. Using the rhesus macaque model, this work was performed to address why infants infected with SIV progress more quickly to AIDS than do adults. Earlier we reported that in adult rhesus macaques, increasing monocyte turnover reflected tissue macrophage damage by SIV and was predictive of terminal disease progression to AIDS. Here we report that uninfected infant rhesus macaques exhibited a higher physiological baseline monocyte turnover rate than adults. Furthermore, once infected with SIV, infants displayed further increased monocyte turnover that may have facilitated the accelerated progression to AIDS. These results support a role for monocytes and macrophages in the pathogenesis of SIV/HIV and begin to explain why infants are more prone to rapid disease progression.

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Increase in Peripheral Blood Intermediate Monocytes is Associated with the Development of Recent-Onset Type 1 Diabetes Mellitus in Children

Cited by 30 publications

References 49 publications

The Potential Role of Trained Immunity in Autoimmune and Autoinflammatory Disorders

The Potential Role of Trained Immunity in Autoimmune and Autoinflammatory Disorders

High-Density Lipoprotein Reduction Differentially Modulates to Classical and Nonclassical Monocyte Subpopulations in Metabolic Syndrome Patients and in LPS-Stimulated Primary Human Monocytes In Vitro

Critical Role for Monocytes/Macrophages in Rapid Progression to AIDS in Pediatric Simian Immunodeficiency Virus-Infected Rhesus Macaques

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