Increase in Paravertebral Muscle Activity in Lumbar Kyphosis Patients by Surface Electromyography Compared With Lumbar Spinal Canal Stenosis Patients and Healthy Volunteers

Enomoto, Mitsuhiro; Ukegawa, Dai; Sakaki, Kyohei; Tomizawa, Shoji; Arai, Yoshiyasu; Kawabata, Shigenori; Kato, Tsuyoshi; Yoshii, Toshitaka; Shinomiya, Kenichi; Atsushi, Okawa

doi:10.1097/bsd.0b013e31825d63c4

Cited by 31 publications

(16 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Paraspinal muscle activity is increased in lumbar kyphosis patients compared with age-matched LSS patients. 33 Chronic increased paraspinal muscle activity in our study subjects may have accelerated PGC-1α mRNA expression in the paraspinal muscles. In fact, Pilegaard et al 34 demonstrated that PGC-1α transcription and mRNA content in vastus lateralis muscles increase after exercise, especially in the trained leg compared with the untrained leg.…”

Section: Discussionmentioning

confidence: 69%

mRNA expressions of peroxisome proliferator-activated receptor gamma coactivator 1α, tumor necrosis factor-α, and interleukin-6 in paraspinal muscles of patients with lumbar kyphosis: a preliminary study

Kudo

Miyakoshi

Hongo

et al. 2018

CIA

View full text Add to dashboard Cite

BackgroundKyphosis is a spine deformity that can lead to falls and reduced quality of life. Peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α) regulates mitochondrial biogenesis and is important for proper functioning of skeletal muscle, including the paraspinal muscles, which support and allow movement of the spine. The role of PGC-1α in paraspinal muscles in lumbar kyphosis has not been examined. We also examined the expressions of the proinflammatory cytokines tumor necrosis factor (TNF)-α and interleukin (IL)-6.MethodsWe obtained paraspinal muscle specimens from 12 patients who underwent posterior lumbar surgery. RNA was isolated from these samples, and quantitative PCR was performed to compare the expression levels of PGC-1α, TNF-α, and IL-6 mRNA between patients with decreased lumbar lordosis (LL) and normal LL patients.ResultsTNF-α and IL-6 mRNA expressions in paraspinal muscles were significantly higher in the decreased LL group than in the normal LL group (P=0.048 for both). PGC-1α mRNA expression was slightly increased in the decreased LL group, but the difference was not significant. Age was significantly positively correlated with PGC-1α mRNA expression (P=0.010). PGC-1α mRNA expression was significantly positively correlated with TNF-α mRNA expression (P=0.022). LL was significantly negatively correlated with PGC-1α, TNF-α, and IL-6 mRNA expressions (P=0.015, 0.036, and 0.010, respectively).ConclusionTNF-α and IL-6 mRNA expressions in paraspinal muscles were significantly higher in the decreased LL group than in the normal LL group. LL was significantly negatively correlated with PGC-1α, TNF-α, and IL-6 mRNA expressions. PGC-1α mRNA expression levels in paraspinal muscles may be affected by lumbar kyphosis.

show abstract

Section: Discussionmentioning

confidence: 69%

mRNA expressions of peroxisome proliferator-activated receptor gamma coactivator 1α, tumor necrosis factor-α, and interleukin-6 in paraspinal muscles of patients with lumbar kyphosis: a preliminary study

Kudo

Miyakoshi

Hongo

et al. 2018

CIA

View full text Add to dashboard Cite

show abstract

“…A report found fatty degeneration of multifidus muscle on the concave side of degenerative scoliosis [12], while hyperplasia of the multifidus muscle and iliopsoas muscle has been reported regarding the convex side of degenerative scoliosis [13]. On the other hand, when Enomoto et al [14] took surface electromyograms of paravertebral muscle activity, they found that compared to lumbar spinal canal stenosis (LSCS), patients with degenerative lumbar scoliosis (DLS) had high paravertebral muscle activity. Yagi et al [11] measured appendicular skeletal muscle mass in patients with DLS and LSCS by DXA and reported that there was no significant difference between the two groups.…”

Section: Discussionmentioning

confidence: 99%

Associations between sarcopenia and degenerative lumbar scoliosis in older women

et al. 2017

View full text Add to dashboard Cite

BackgroundAge-related sarcopenia can cause various forms of physical disabilities. We investigated how sarcopenia affects degenerative lumbar scoliosis (DLS) and lumbar spinal canal stenosis (LSCS).MethodsSubjects comprised 40 elderly women (mean age 74 years) with spinal disease whose chief complaints were low back pain and lower limb pain. They included 15 cases of DLS (mean 74.8 years) and 25 cases of LSCS (mean age 72.9 years).We performed whole-body dual-energy X-ray absorptiometry (DXA) to analyze body composition, including appendicular and trunk skeletal muscle mass index (SMI; lean mass (kg)/height (m)2) and bone mineral density (BMD). A diagnostic criterion for sarcopenia was an appendicular SMI <5.46. To check spinal alignment, lumbar scoliosis (LS), sagittal vertical axis (SVA), thoracic kyphosis (TK), lumbar lordosis (LL), pelvic tilt (PT), pelvic incidence (PI), sacral slope (SS), and vertebral rotational angle (VRA) were measured. Clinical symptoms were determined from the Japanese Orthopedic Association scores, low back pain visual analog scale, and Roland-Morris Disability Questionnaire (RDQ). Criteria for DLS were lumbar scoliosis >10° and a sagittal vertical axis (SVA) >50 mm. Sarcopenia prevalence, correlations between spinal alignment, BMD, and clinical symptoms with appendicular and trunk SMIs, and correlation between spinal alignment and clinical symptoms were investigated.ResultsDLS cases had significantly lower body weight, BMI, lean mass arm, and total lean mass than LSCS cases. Sarcopenia prevalence rates were 4/25 cases (16%) in LSCS and 7/15 cases (46.6%) in DLS, revealing a high prevalence in DLS. Appendicular SMIs were DLS 5.61 and LSCS 6.13 (p < 0.05), and trunk SMIs were DLS 6.91 and LSCS 7.61 (p < 0.01) showing DLS to have significantly lower values than LSCS. Spinal alignment correlations revealed the appendicular SMI was negatively correlated with PT (p < 0.05) and the trunk SMI was found to have a significant negative correlation with SVA, PT, LS, and VRA (p < 0.05). The trunk SMI was found to have a significant positive correlation with BMD (p < 0.05). As for clinical symptoms, RDQ was negatively correlated with appendicular SMI and positively correlated with PT (P < 0.05).ConclusionsSarcopenia complications were noted in 16% of LSCS patients and a much higher percentage, or 46.6%, of DLS patients. Appendicular and trunk SMIs were both lower in DLS, suggesting that sarcopenia may be involved in scoliosis. The appendicular skeletal muscle was related to posterior pelvic tilt, while the trunk muscle affected stooped posture, posterior pelvic tilt, lumbar scoliosis, and vertebral rotation. Decreases in trunk muscle mass were also associated with osteoporosis. Moreover, RDQ had a negative correlation with appendicular skeletal muscle mass and a positive correlation with PT, suggesting that sarcopenia may be associated with low back pain as a result of posterior pelvic tilt. Our research reveals for the first time how sarcopenia is involved in spinal deformations, suggesting decre...

show abstract

“…In addition, some patients complain of recurrent chronic LBP and sagittal decompensation related to posture even after surgical correction of kyphotic spinal deformities 2 , 31 ) . Exercises that help train lumbar stabilizing muscles are typically adopted for conservative treatments of chronic LBP and the correction of kyphotic postures 16 , 17 , 18 , 19 , 20 , 32 ) . Patients with LBP cannot sufficiently activate the deep lumbar stabilizers 13 , 14 , 15 ) , and thus, extensive LM muscle atrophy is a characteristic of LDK patients 33 ) .…”

Section: Discussionmentioning

confidence: 99%

The effects of transcutaneous neuromuscular electrical stimulation on the activation of deep lumbar stabilizing muscles of patients with lumbar degenerative kyphosis

Kim

Jung

et al. 2016

J Phys Ther Sci

View full text Add to dashboard Cite

[Purpose] To investigate the effectiveness of three different neuromuscular electrical stimulation (NMES) protocols for the deep lumbar stabilizing muscles of patients with lumbar degenerative kyphosis (LDK). [Subjects and Methods] Twenty patients with LDK were recruited. Three stimulation protocols were investigated: stimulation of the abdominal muscles (protocol A); stimulation of the lumbar muscles (protocol B); and simultaneous stimulation of the abdominal and lumbar muscles (protocol A+B). Images of the obliquus externus (OE), obliquus internus (OI), transversus abdominis (TrA), and lumbar multifidus (LM) muscles were captured by real-time ultrasound imaging (RUSI). [Results] The thickness of LM was significantly greater during stimulation than at rest for all three protocols. Thicknesses of the abdominal muscles (TrA, OI, and OE) were significantly greater during stimulation than at rest for protocols A and A+B. Thickness increases in LM were significantly greater during protocols B and A+B, but not during protocol A. Thickness increases in the abdominal muscles (TrA, OI, and OE) were significantly greater during protocols A and A+B, but not during protocol B. [Conclusion] NMES can significantly activate the deep lumbar stabilizing muscles of patients with LDK. Protocol A+B of NMES is recommended to aid postural correction and low back pain (LBP) in patients with LDK.

show abstract

Increase in Paravertebral Muscle Activity in Lumbar Kyphosis Patients by Surface Electromyography Compared With Lumbar Spinal Canal Stenosis Patients and Healthy Volunteers

Cited by 31 publications

References 3 publications

mRNA expressions of peroxisome proliferator-activated receptor gamma coactivator 1α, tumor necrosis factor-α, and interleukin-6 in paraspinal muscles of patients with lumbar kyphosis: a preliminary study

mRNA expressions of peroxisome proliferator-activated receptor gamma coactivator 1α, tumor necrosis factor-α, and interleukin-6 in paraspinal muscles of patients with lumbar kyphosis: a preliminary study

Associations between sarcopenia and degenerative lumbar scoliosis in older women

The effects of transcutaneous neuromuscular electrical stimulation on the activation of deep lumbar stabilizing muscles of patients with lumbar degenerative kyphosis

Contact Info

Product

Resources

About

Increase in Paravertebral Muscle Activity in Lumbar Kyphosis Patients by Surface Electromyography Compared With Lumbar Spinal Canal Stenosis Patients and Healthy Volunteers

Cited by 31 publications

References 3 publications

mRNA expressions of peroxisome proliferator-activated receptor gamma coactivator 1&alpha;, tumor necrosis factor-&alpha;, and interleukin-6 in paraspinal muscles of patients with lumbar kyphosis: a preliminary study

mRNA expressions of peroxisome proliferator-activated receptor gamma coactivator 1&alpha;, tumor necrosis factor-&alpha;, and interleukin-6 in paraspinal muscles of patients with lumbar kyphosis: a preliminary study

Associations between sarcopenia and degenerative lumbar scoliosis in older women

The effects of transcutaneous neuromuscular electrical stimulation on the activation of deep lumbar stabilizing muscles of patients with lumbar degenerative kyphosis

Contact Info

Product

Resources

About

mRNA expressions of peroxisome proliferator-activated receptor gamma coactivator 1α, tumor necrosis factor-α, and interleukin-6 in paraspinal muscles of patients with lumbar kyphosis: a preliminary study

mRNA expressions of peroxisome proliferator-activated receptor gamma coactivator 1α, tumor necrosis factor-α, and interleukin-6 in paraspinal muscles of patients with lumbar kyphosis: a preliminary study