Increase in oxidative stress biomarkers in dogs with ascending–descending myelomalacia following spinal cord injury

Marquis, Andrew; Packer, Rebecca A.; Borgens, Richard B.; Duerstock, Bradley S.

doi:10.1016/j.jns.2015.04.003

Cited by 27 publications

(46 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Natural substances containing phenolic derivatives, such as flavonoids, minimize oxidative damage by inhibiting the action of free radicals, preventing lipid peroxidation, and therefore improving endothelial and neuroprotective functions (MENDES, 2012). It should also be mentioned here that a recent study observed an increase in the concentrations of isoprostanes and acrolein in the spinal cord of dogs with post-traumatic myelomalacia, confirming the nerve degeneration was due to oxidative stress, similar to what occurs in humans with recurrent neurodegeneration of the spinal cord after injury (MARQUIS et al, 2015).…”

Section: Biomarkers Of Oxidative Stresssupporting

confidence: 77%

“…Nowadays, other biomarkers of lipid peroxidation, such as isoprostanes and acrolein, are also considered as important for determining oxidative damage in humans and, more recently, in animals (LIMA; ABDALLA, 2001;MARQUIS et al, 2015) Oxidative stress and related diseases There are currently lines of scientific evidence showing that many diseases are related to the oxidative stress caused by ROS or RNS. The most severe damages are the ones affecting the DNA or RNA of the cell.…”

Section: Biomarkers Of Oxidative Stressmentioning

confidence: 99%

See 1 more Smart Citation

Oxidative stress in dogs

Russo

Bracarense

2016

SCA

View full text Add to dashboard Cite

Reactive oxygen species (ROS), also known as free radicals, are generated during cellular respiration. Under normal conditions, the body has the ability to neutralize the effects of free radicals by using its antioxidant defenses. In the case of an imbalance between oxidants and antioxidants, free radical production exceeds the capacity of organic combustion, resulting in oxidative stress. Of all the cellular components compromised by the harmful effects of ROS, the cell membrane is the most severely affected owing to lipid peroxidation, which invariably leads to changes in the membrane structure and permeability. With lipid peroxidation of the cell membrane, some by-products can be detected and measured in tissues, blood, and other bodily fluids. The measurement of biomarkers of oxidative stress is commonly used to quantify lipid peroxidation of the cell membrane in humans, a species in which ROS can be considered as a cause or consequence of oxidative stress-related diseases. In dogs, few studies have demonstrated this correlation. The present review aims to identify current literature knowledge relating to oxidative stress diseases and their detection in dogs. Key words: Oxidative stress. Lipid peroxidation. Free radicals. Dogs. ResumoNos processos decorrentes da respiração celular, são gerados produtos denominados espécimes reativos de oxigênio (EROS), conhecidos também como radicais livres. Em condições normais, o organismo possui capacidade de neutralizar os efeitos dos radicais livres utilizando suas defesas antioxidantes. Em situações de desequilíbrio entre agentes oxidantes e antioxidantes, a produção de radicais livres excede a capacidade orgânica de neutralização, resultando na condição conhecida como estresse oxidativo. Dentre todos os componentes celulares atingidos pelos efeitos nocivos dos EROS, as membranas celulares são as estruturas mais severamente acometidas, devido à peroxidação lipídica, que leva, invariavelmente, a alterações estruturais e também na sua permeabilidade. Na peroxidação lipídica da membrana celular, alguns subprodutos podem ser detectados e mensurados nos tecidos, sangue e outros fluidos corpóreos. A mensuração de biomarcadores de estresse oxidativo é habitualmente utilizada para quantificar a lipoperoxidação da membrana celular em humanos, espécie onde as EROS podem ser consideradas como causa ou consequência de doenças relacionadas ao estresse oxidativo. Nos cães, alguns poucos estudos demonstram essa correlação. A presente revisão tem como principal objetivo verificar na literatura, onde se encontra atualmente o conhecimento relacionando o estresse oxidativo às doenças em cães bem como as possíveis formas de detecção de biomarcadores na espécie canina. Palavras-chave: Estresse oxidativo. Lipoperoxidação. Radicais livres. Cães.

show abstract

Section: Biomarkers Of Oxidative Stresssupporting

confidence: 77%

Section: Biomarkers Of Oxidative Stressmentioning

confidence: 99%

Oxidative stress in dogs

Russo

Bracarense

2016

SCA

View full text Add to dashboard Cite

show abstract

“…Indeed, 1 dog showed onset of signs 5 days after presentation, then remained static for 7 days. The reason for the variability in progression of signs is unknown but may reflect the vascular nature of this disease . A recent study described intramedullary as well as subdural hemorrhages and speculated that spinal cord debris admixed with CSF accumulating in the central canal were propelled cranially and caudally due to the increased intramedullary pressure causing longitudinal spreading of the necrotic tissue and subsequent hemorrhagic lysis of adjacent spinal cord segments .…”

Section: Discussionmentioning

confidence: 99%

“…9 While there are several published studies on the histopathologic lesions, risk factors for its development, diagnostic, and imaging characteristics of PMM, to date, there is no large-scale retrospective study describing its clinical characteristics. 4,[10][11][12][13][14][15] The goal of this study was to describe the clinical signs associated with PMM, including their time of onset and their rate of progression in a large case cohort.…”

mentioning

confidence: 99%

Clinical Characteristics of Dogs with Progressive Myelomalacia Following Acute Intervertebral Disc Extrusion

Castel

Olby

Mariani

et al. 2017

Veterinary Internal Medicne

View full text Add to dashboard Cite

BackgroundProgressive myelomalacia (PMM) is a catastrophic disease associated with acute intervertebral disc extrusion (IVDE). Published data on the clinical characteristics of this disease are limited.ObjectiveTo describe the onset and progression of clinical signs of PMM in a large case cohort.AnimalsFifty‐one dogs, 18 with histopathologically confirmed PMM, 33 presumptively diagnosed based on clinical signs and diagnostic imaging.MethodsRetrospective study. Dogs with confirmed IVDE and either a histopathologic diagnosis of PMM or a high clinical suspicion were identified by medical record search. Data on nature and progression of signs were extracted.ResultsTwenty‐four of 51 dogs were Dachshunds. T12–T13 was the most common site of disc extrusion (12 of 56), and 18 of 55 of mid‐to‐caudal lumbar discs (between L3 and L6) were affected. Onset of PMM signs ranged from present at first evaluation (17/51) to 5 days after presentation, with 25 of 51 cases developing signs within 48 hours. Progression of signs from onset of PMM to euthanasia or death, excluding 7 cases euthanized at presentation, ranged from 1 to 13 days with 23 being euthanized within 3 days. Nonspecific systemic signs were documented in 30 of 51 dogs.Conclusion and Clinical ImportanceThe majority of dogs developed PMM within 2 days of presentation and was euthanized within another 3 days. However, onset can be delayed up to 5 days after presentation with progression to euthanasia taking as long as 2 weeks. Mid‐to‐caudal lumbar discs might be associated with an increased risk of PMM.

show abstract

“…Most commonly, it is a focal lesion limited to the epicenter of spinal cord damage, but sometimes myelomalacia may ascend and/or descend from the initial site of contusion. The latter phenomenon has been referred to as the ascending syndrome, ascending–descending diffuse myelomalacia, ascending hemorrhagic myelomalacia, progressive hemorrhagic myelomalacia, and progressive myelomalacia . Although generally uncommon, occurring in 9–13% of acute intervertebral disk herniation cases in which there has been loss of “deep pain” sensation, progressive myelomalacia is typically fatal .…”

Section: Introductionmentioning

confidence: 99%

Single‐shot Turbo Spin Echo Pulse Sequence Findings in Dogs With and Without Progressive Myelomalacia

Gilmour

Jeffery

Miles

et al. 2016

Vet Radiology Ultrasound

View full text Add to dashboard Cite

Progressive myelomalacia is an uncommon type of ischemic, hemorrhagic spinal cord infarction. Diagnosis can be difficult, but prompt recognition is important. We hypothesized that cerebrospinal fluid signal attenuation on magnetic resonance (MR) images would be more extensive in dogs that developed progressive myelomalacia vs. control dogs. A retrospective analytic cohort study was designed. Dogs were included if they presented for acute paraplegia and loss of deep pain perception and had undergone MR imaging using both sagittal single-shot turbo spin echo (SSTSE) and standard sagittal T2-weighted fast spin echo (T2W) pulse sequences. Dogs were divided into progressive myelomalacia and control groups for comparisons. All MR examinations were evaluated by three reviewers blinded to patient outcome. Length of cerebrospinal fluid attenuation was recorded as a ratio to the length of the L2 vertebral body in SSTSE and T2W sequences (CSF:L2 and CSF:L2 , respectively). Length of intramedullary spinal cord hyperintensity was recorded as a ratio to the length of the L2 vertebral body in T2W sequences. A total of 21 dogs were included (five in the progressive myelomalacia group and 16 in the control group). The mean CSF:L2 attenuation value was significantly higher in dogs that developed progressive myelomalacia (CSF:L2 = 10.7) compared to controls (CSF:L2 = 5.4; P = 0.015). A cut off ratio of attenuation >7.4 provided optimal differentiation between groups in this study. Findings supported the conclusion that dogs with CSF:L2 ≤ 7.4 are unlikely to develop progressive myelomalacia while dogs with CSF:L2 > 7.4 are indeterminate for progressive myelomalacia.

show abstract

Increase in oxidative stress biomarkers in dogs with ascending–descending myelomalacia following spinal cord injury

Cited by 27 publications

References 25 publications

Oxidative stress in dogs

Oxidative stress in dogs

Clinical Characteristics of Dogs with Progressive Myelomalacia Following Acute Intervertebral Disc Extrusion

Single‐shot Turbo Spin Echo Pulse Sequence Findings in Dogs With and Without Progressive Myelomalacia

Contact Info

Product

Resources

About