Increase in number of the gap junctions between satellite neuroglial cells during lifetime: An ultrastructural study in rabbit spinal ganglia from youth to extremely advanced age

Martinelli, Carla; Sartori, Patrizia; Palo, S. De; Ledda, M.; Pannese, Ennio

doi:10.1016/j.brainresbull.2005.05.021

Cited by 15 publications

(3 citation statements)

References 32 publications

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“…SCs and satellite cells that ensheathe sensory neurons in the dorsal root ganglia (DRG) proliferate and release soluble factors when peripheral somatic nerves are injured [5]. This increases the number of satellite cells that support neuronal survival during PNS regeneration [6-9]. Basic fibroblast growth factor (FGF-2) has been described as a trophic factor that induces glial cell proliferation by binding to the FGF-2 receptor type 1/2 (FGFR 1/2) during both development and regeneration of PNS [10].…”

Section: Introductionmentioning

confidence: 99%

Bone marrow-derived fibroblast growth factor-2 induces glial cell proliferation in the regenerating peripheral nervous system

Ribeiro-Resende

Carrier-Ruiz

Lemes

et al. 2012

Molecular Neurodegeneration

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BackgroundAmong the essential biological roles of bone marrow-derived cells, secretion of many soluble factors is included and these small molecules can act upon specific receptors present in many tissues including the nervous system. Some of the released molecules can induce proliferation of Schwann cells (SC), satellite cells and lumbar spinal cord astrocytes during early steps of regeneration in a rat model of sciatic nerve transection. These are the major glial cell types that support neuronal survival and axonal growth following peripheral nerve injury. Fibroblast growth factor-2 (FGF-2) is the main mitogenic factor for SCs and is released in large amounts by bone marrow-derived cells, as well as by growing axons and endoneurial fibroblasts during development and regeneration of the peripheral nervous system (PNS).ResultsHere we show that bone marrow-derived cell treatment induce an increase in the expression of FGF-2 in the sciatic nerve, dorsal root ganglia and the dorsolateral (DL) region of the lumbar spinal cord (LSC) in a model of sciatic nerve transection and connection into a hollow tube. SCs in culture in the presence of bone marrow derived conditioned media (CM) resulted in increased proliferation and migration. This effect was reduced when FGF-2 was neutralized by pretreating BMMC or CM with a specific antibody. The increased expression of FGF-2 was validated by RT-PCR and immunocytochemistry in co-cultures of bone marrow derived cells with sciatic nerve explants and regenerating nerve tissue respectivelly.ConclusionWe conclude that FGF-2 secreted by BMMC strongly increases early glial proliferation, which can potentially improve PNS regeneration.

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Section: Introductionmentioning

confidence: 99%

Bone marrow-derived fibroblast growth factor-2 induces glial cell proliferation in the regenerating peripheral nervous system

Ribeiro-Resende

Carrier-Ruiz

Lemes

et al. 2012

Molecular Neurodegeneration

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“…see MeierRuge et al 1976;Mann et al 1978;van den Bosch de Aguilar and Vanneste 1980;Finch and Morgan 1990). There is evidence suggesting that satellite cells of sensory ganglia perform the following roles (for more details see Pannese 1981Pannese , 1994Martinelli et al 2005;Thippeswamy et al 2005): (1) metabolic support of ganglionic neurons;…”

Section: Discussionmentioning

confidence: 99%

The perineuronal glial tissue of spinal ganglia. Quantitative changes in the rabbit from youth to extremely advanced age

et al. 2006

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The volumes of the nerve cell bodies and those of the enveloping satellite cell sheaths from spinal ganglia were determined by morphometric methods applied to electron micrographs in young, adult, old and very old rabbits. The mean volume of the nerve cell bodies increased progressively with age; this is probably related to the increase with age of the body size of the rabbits studied. The mean volume of the satellite cell sheaths did not differ significantly in young, adult and old animals, but was significantly smaller in very old animals. It is extremely unlikely that this marked reduction in the volume of the satellite cell sheath is the result of a pathological process. The mean value of the volume ratio between the satellite cell sheaths and the related nerve cell bodies did not differ significantly in young and adult animals, but was significantly smaller in old and very old animals. This ratio was particularly low in very old animals. Our analysis showed that in each age group the volume of the satellite cell sheath is linearly related to the volume of the related nerve cell body. This result suggests that in rabbit spinal ganglia the quantitative relations between glial and nervous tissue are tightly controlled throughout life. It is suggested that ganglionic neurons release signals to influence and control the volume of their associated glial tissue. Since satellite cells have important support roles for the neurons they surround, it is likely that the marked reduction in the volume of perineuronal sheaths in the extremely advanced age is accompanied by a reduction of those roles, with negative consequences for neuronal activity.

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“…In rabbit spinal ganglia, the gap junctions between perineuronal satellite cells -which are mainly composed of connexin43increase in number with age, whereas the mean size of individual gap junctions remains constant. 133 In spinal ganglia of the senescent mouse, both gap junction number and dye coupling between satellite cells increase, 134 whereas connexin43 expression decreases. 135 These contrasting changes in the senescent mouse could be related to the presence of connexin types other than connexin43, in the gap junctions between the satellite cells of these animals.…”

Section: Satellite Cells In Sensory Gangliamentioning

confidence: 99%

Quantitative, structural and molecular changes in neuroglia of aging mammals: A review

Pannese

2021

Eur J Histochem

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The neuroglia of the central and peripheral nervous systems undergo numerous changes during normal aging. Astrocytes become hypertrophic and accumulate intermediate filaments. Oligodendrocytes and Schwann cells undergo alterations that are often accompanied by degenerative changes to the myelin sheath. In microglia, proliferation in response to injury, motility of cell processes, ability to migrate to sites of neural injury, and phagocytic and autophagic capabilities are reduced. In sensory ganglia, the number and extent of gaps between perineuronal satellite cells – that leave the surfaces of sensory ganglion neurons directly exposed to basal lamina– increase significantly. The molecular profiles of neuroglia also change in old age, which, in view of the interactions between neurons and neuroglia, have negative consequences for important physiological processes in the nervous system. Since neuroglia actively participate in numerous nervous system processes, it is likely that not only neurons but also neuroglia will prove to be useful targets for interventions to prevent, reverse or slow the behavioral changes and cognitive decline that often accompany senescence.

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Increase in number of the gap junctions between satellite neuroglial cells during lifetime: An ultrastructural study in rabbit spinal ganglia from youth to extremely advanced age

Cited by 15 publications

References 32 publications

Bone marrow-derived fibroblast growth factor-2 induces glial cell proliferation in the regenerating peripheral nervous system

Bone marrow-derived fibroblast growth factor-2 induces glial cell proliferation in the regenerating peripheral nervous system

The perineuronal glial tissue of spinal ganglia. Quantitative changes in the rabbit from youth to extremely advanced age

Quantitative, structural and molecular changes in neuroglia of aging mammals: A review

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