Increase in nerve fibers and loss of mast cells in polycystic and postmenopausal ovaries

Heider, Ulrike; Pedal, I; Spanel‐Borowski, Katharina

doi:10.1016/s0015-0282(01)01805-2

Cited by 95 publications

(83 citation statements)

References 27 publications

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“…Given that ovarian kiss1r expression increases with age, future directions should evaluate the response of this receptor to the administration of kisspeptin peptide antagonist (such as peptide 234) in vitro and in vivo and whether this antagonist could reverse some of the features of ovarian aging. It is possible that the rise in adrenergic activity in the ovary that occurs naturally with aging provokes the increase in ovarian kisspeptin [4,9]. One would expect that the upregulation of kiss1r with age might be due to a decline is systemic plasma kisspeptin levels.…”

Section: Discussionmentioning

confidence: 99%

“…We and others have documented that reproductive aging is characterized by reduced hypothalamic kiss1 expression [7,8]. On the other hand, women with diminished ovarian reserve have a significant increase in ovarian sympathetic nerve fibers [9] whose stimulation with β-adrenergic agonist induces ovarian kiss1 expression [4]. Given this background, we hypothesized that ovarian kisspeptin expression is upregulated during ovarian aging.…”

Section: Introductionmentioning

confidence: 96%

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Ovarian kisspeptin expression is related to age and to monocyte chemoattractant protein-1

Merhi

Thornton

Bonney

et al. 2016

J Assist Reprod Genet

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Purpose The objective of this study was to test the hypothesis that ovarian kisspeptin (kiss1) and its receptor (kiss1r) expression are affected by age, obesity, and the age-and obesityrelated chemokine monocyte chemoattractant protein-1 (MCP-1). Methods Ovaries from reproductive-aged and older C57BL/ 6J mice fed normal chow (NC) or high-fat (HF) diet, ovaries from age-matched young MCP-1 knockout and young control mice on NC, and finally, cumulus and mural granulosa cells (GCs) from women who underwent in vitro fertilization (IVF) were collected. Kiss1, kiss1r, anti-Mullerian hormone (AMH), and AMH receptor (AMHR-II) messenger RNA (mRNA) expression levels were quantified using real-time polymerase chain reaction (RT-PCR).Results In mouse ovaries, kiss1 and kiss1r mRNA levels were significantly higher in old compared to reproductive-aged mice, and diet-induced obesity did not alter kiss1 or kiss1r mRNA levels. Compared to young control mice, young MCP-1 knockout mice had significantly lower ovarian kiss1 mRNA but significantly higher AMH and AMHR-II mRNA levels. In human cumulus GCs, kiss1r mRNA levels were positively correlated with age but not with BMI. There was no expression of kiss1 mRNA in either cumulus or mural GCs. Conclusion These data suggest a possible age-related physiologic role for the kisspeptinergic system in ovarian physiology. Additionally, the inflammatory MCP-1 may be associated with kiss1 and AMH genes, which are important in ovulation and folliculogenesis, respectively.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Ovarian kisspeptin expression is related to age and to monocyte chemoattractant protein-1

Merhi

Thornton

Bonney

et al. 2016

J Assist Reprod Genet

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“…Furthermore, nerve fibers are distributed through the different ovarian compartments, such as blood vessels, ovarian stroma and follicle wall (7,19). PCOS ovaries have a higher density of nerve fibers than ovaries from cyclic women (20). The presence of extrinsic innervations and intrinsic neurons in the human ovary raises the possibility that they may be engaged in regulating ovarian function (19).…”

Section: Neuronal Pathwaysmentioning

confidence: 99%

“…We know that the PCOS ovaries have a higher nerve density (20), so potentially there might also be a difference in the presence or the amount of afferent nerve fibers. These could both result in altered afferent feedback in the PCOS after ovarian mechanical manipulation.…”

Section: Neuronal Pathwaysmentioning

confidence: 99%

Influence of ovarian manipulation on reproductive endocrinology in polycystic ovarian syndrome and regularly cycling women

Hendriks¹,

König

Soleman

et al. 2013

European Journal of Endocrinology

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Objective: Little is known about the function of the ovarian neuronal network in humans. In many species, copulation influences endocrinology through this network. As a first step, the possible influence of ovarian mechanical manipulation on pituitary and ovarian hormones was evaluated in polycystic ovarian syndrome (PCOS) and regularly cycling women. Design: Prospective case-control study (2008)(2009)(2010). Methods: Ten PCOS women (Rotterdam criteria) undergoing ovulation induction with recombinant-FSH and ten normal ovulatory controls were included in an academic fertility clinic. In the late follicular phase blood was drawn every 10 min for 6 h. After 3 h the ovaries were mechanically manipulated by moving a transvaginal ultrasound probe firmly over each ovary ten times. Main outcome measures were LH and FSH pulsatility and ovarian hormones before and after ovarian manipulation. Results: All PCOS patients showed an LH decline after the ovarian manipulation (before 13.0 U/l and after 10.4 U/l, P!0.01), probably based on a combination of a longer LH pulse interval and smaller amplitude (PZ0.07). The controls showed no LH change (before 9.6 U/l and after 9.3 U/l, PZ0.67). None of the ovarian hormones (estradiol, progesterone, anti-Mü llerian hormone, inhibin B, androstenedione and testosterone) changed in either group. Conclusions: Ovarian mechanical manipulation lowers LH secretion immediately and typically only in preovulatory PCOS patients. The immediate LH change after the ovarian manipulation without any accompanying ovarian hormonal changes point to nonhormonal communication from the ovaries to the pituitary. A neuronal pathway from the ovaries communicating to the hypothalamic-pituitary system is the most reasonable explanation.

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“…They are considered as critical mediators of ADIM functions (Kalesnikoff and Galli, 2008), and, in the ovary, are in fact restricted to the interstitial cortical tissue and to the medulla (Reibiger and Spanel-Borowski, 2000;Heider et al, 2001). Garbage removal by macrophage phagocytosis and connective tissue substitution are judged as the final steps of luteolysis.…”

Section: Microvascular and Steroidogenic Cells As Luteovascular Unit mentioning

confidence: 99%

Five different phenotypes of endothelial cell cultures from the bovine corpus luteum: Present outcome and role of potential dendritic cells in luteolysis

Spanel‐Borowski

2011

Molecular and Cellular Endocrinology

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Increase in nerve fibers and loss of mast cells in polycystic and postmenopausal ovaries

Cited by 95 publications

References 27 publications

Ovarian kisspeptin expression is related to age and to monocyte chemoattractant protein-1

Ovarian kisspeptin expression is related to age and to monocyte chemoattractant protein-1

Influence of ovarian manipulation on reproductive endocrinology in polycystic ovarian syndrome and regularly cycling women

Five different phenotypes of endothelial cell cultures from the bovine corpus luteum: Present outcome and role of potential dendritic cells in luteolysis

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